Tumor Suppressor Genes
DOI: 10.1385/1-59259-329-1:349
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Analyzing the Function of Tumor Suppressor Genes Using a Drosophila Model

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Cited by 10 publications
(20 citation statements)
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“…Reducing Ras levels in cno R2 clones did not significantly affect the number of progenitors, but the morphology and size of the clones/NBs were overall more similar to those of WT clones (Fig. 4T-V As mentioned above, Ras V12 scrib clones promote overgrowth in epithelial tissues (Brumby and Richardson, 2003;Pagliarini et al, 2003). Given that in NBII lineages cno R2 loss induced Ras activation and tumor-like overgrowth in a scrib 1 background, we tested the effect of directly expressing Ras V12 on scrib NBII clones in larval brains.…”
Section: Acd Is Substantially Altered In Cno Scrib Double-mutant Nbiimentioning
confidence: 62%
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“…Reducing Ras levels in cno R2 clones did not significantly affect the number of progenitors, but the morphology and size of the clones/NBs were overall more similar to those of WT clones (Fig. 4T-V As mentioned above, Ras V12 scrib clones promote overgrowth in epithelial tissues (Brumby and Richardson, 2003;Pagliarini et al, 2003). Given that in NBII lineages cno R2 loss induced Ras activation and tumor-like overgrowth in a scrib 1 background, we tested the effect of directly expressing Ras V12 on scrib NBII clones in larval brains.…”
Section: Acd Is Substantially Altered In Cno Scrib Double-mutant Nbiimentioning
confidence: 62%
“…2A-B″ It is generally accepted that cancer is a multistep process, in which multiple genome alterations are required to render a carcinogenic phenotype Weinberg, 2000, 2011). In Drosophila, the first demonstration of cooperative tumorigenesis came from studies in which mutations in tumor suppressor genes, with altered cell polarity, showed neoplastic tumor growth in combination with the constitutive activation of the oncogene Ras85D (Ras85D V12 or Ras V12 ) (Brumby and Richardson, 2003;Pagliarini et al, 2003). Given that cooperation between two oncogenes or two tumor suppressor genes can also lead to hyperplasia or neoplasia (Briggs et al, 2008;Land et al, 1983;Liu et al, 2014), we considered whether the simultaneous loss of scrib and cno in clones could lead to a tumor-like overgrowth.…”
Section: Resultsmentioning
confidence: 99%
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“…In addition, targeted genetic interaction studies as well as large scale modifier screens can be performed quickly and inexpensively in flies. As a result of these advantages, flies have been used increasingly as a model to study cancer pathogenesis [18]. In particular, studies have shown Drosophila to be a valuable tool for understanding the roles of DNA repair genes involved in cancer predisposition.…”
Section: Introductionmentioning
confidence: 99%