This research explores the transformative impact of AI, Blockchain, and IoT on entrepreneurship and industry evolution. Entrepreneurs, facing unprecedented challenges to traditional models, are utilizing these technologies to reshape operations and revolutionize industries. The study comprehensively analyzes their multifaceted impact on ventures, business models, and industry structures. The investigation begins with a focus on AI, examining how it empowers entrepreneurs through machine learning and natural language processing. This fosters data-driven decisions, process automation, and the creation of innovative products. The study evaluates the disruptive implications of AI across industries, considering both opportunities and challenges. Blockchain, known for decentralization and transparency, is another key area. The research dissects how entrepreneurs integrate blockchain for enhanced security, transparency, and efficiency. It explores its role in reshaping financial transactions, supply chain management, and decentralized applications, showcasing how entrepreneurs leverage these features for a competitive edge. The Internet of Things is the third critical component, enabling entrepreneurs to create connected ecosystems and optimize operations. Case studies illustrate how entrepreneurs capitalize on IoTgenerated data for business growth and unique value propositions. The study also delves into the collective impact of AI, Blockchain, and IoT on traditional industries, identifying areas of disruption and new market dynamics. Through a synthesis of quantitative and qualitative data, this research contributes to a nuanced understanding of the intricate interplay between technology, entrepreneurship, and industry evolution.