Analyzing the relationship between tissue color observed in VELscope examination and histopathological factors in OSCC patients

Amirchaghmaghi, Maryam; Mohtasham, Nooshin; Delavarian, Zahra; Shakeri, Mohammad Taghi; Taghizadeh, Ava; Khazaeni, Kamran; Hatami, Masoud

doi:10.1016/j.pdpdt.2022.103248

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Oral squamous cell carcinoma (OSCC) is the most common histological type of head and neck cancer, accounting for 90% of all cases [1][2][3]. During the past 10 years, despite the extensive use of surgery, chemotherapy, radiation, and immunotherapy, the 5-year survival rate of OSCC patients has remained low [2,4]. Chemotherapy has a crucial role in OSCC treatment among the aforementioned traditional methods.…”

Section: Introductionmentioning

confidence: 99%

Nuciferine Inhibits Oral Squamous Cell Carcinoma Partially through Suppressing the STAT3 Signaling Pathway

Xie,

Chen,

Zhou

2023

IJMS

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Oral squamous cell carcinoma (OSCC) poses a significant obstacle to the worldwide healthcare system. Discovering efficient and non-toxic medications is crucial for managing OSCC. Nuciferine, an alkaloid with an aromatic ring, is present in the leaves of Nelumbo nucifera. It has been proven to play a role in multiple biological processes, including the inhibition of inflammation, regulation of the immune system, formation of osteoclasts, and suppression of tumors. Despite the demonstrated inhibitory effects of nuciferine on different types of cancer, there is still a need for further investigation into the therapeutic effects and potential mechanisms of nuciferine in OSCC. Through a series of in vitro experiments, it was confirmed that nuciferine hindered the growth, movement, and infiltration, while enhancing the programmed cell death of OSCC cells. Furthermore, the administration of nuciferine significantly suppressed the signal transducer and activator of transcription 3 (STAT3) signaling pathway in comparison to other signaling pathways. Moreover, the activation of the STAT3 signaling pathway by colivelin resulted in the reversal of nuciferine-suppressed OSCC behaviors. In vivo, we also showed the anti-OSCC impact of nuciferine using the cell-based xenograft (CDX) model in nude mice. Nonetheless, colivelin diminished the tumor-inhibiting impact of nuciferine, suggesting that nuciferine might partially impede the advancement of OSCC by suppressing the STAT3 signaling pathway. Overall, this research could offer a fresh alternative for the pharmaceutical management of OSCC.

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Section: Introductionmentioning

confidence: 99%

Nuciferine Inhibits Oral Squamous Cell Carcinoma Partially through Suppressing the STAT3 Signaling Pathway

Xie,

Chen,

Zhou

2023

IJMS

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Colorimetric sensing of oral cancer overexpressed 1 gene in saliva samples with a low-background G-quadruplex DNAzyme probe

Ming,

Zhao,

Zeng

et al. 2025

Microchemical Journal

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Virtual Tumor Mapping: A New Standard for Surgeon–Pathologist Collaboration in Treating Oral Squamous Cell Carcinoma

Michcik,

Jopek,

Pęksa

et al. 2024

Cancers

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Background: The histopathological assessment is critical in the comprehensive treatment process for patients diagnosed with oral squamous cell carcinoma (OSCC). A detailed and precise specimen characterization is essential to facilitate effective surgeon–pathologist communication. Methods: In response to this need, a user-friendly virtual communication protocol utilizing a 3D scanner has been developed. This study involved 50 patients with OSCC, whose resected tumors were directly scanned in the operating room and subsequently annotated and characterized using available software. Results: The direct application of annotations and descriptions onto the virtual tumor specimens significantly enhanced the quantity and accuracy of information conveyed to the pathologist. Conclusions: The proposed solution’s repeatability and standardized approach make integration into routine clinical practice feasible, thereby establishing a potential new standard in the field.

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Analyzing the relationship between tissue color observed in VELscope examination and histopathological factors in OSCC patients

Cited by 3 publications

References 23 publications

Nuciferine Inhibits Oral Squamous Cell Carcinoma Partially through Suppressing the STAT3 Signaling Pathway

Nuciferine Inhibits Oral Squamous Cell Carcinoma Partially through Suppressing the STAT3 Signaling Pathway

Colorimetric sensing of oral cancer overexpressed 1 gene in saliva samples with a low-background G-quadruplex DNAzyme probe

Virtual Tumor Mapping: A New Standard for Surgeon–Pathologist Collaboration in Treating Oral Squamous Cell Carcinoma

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