Anamnestic risk factor questionnaire as reliable diagnostic instrument for osteoporosis (reduced bone morphogenic density)

Abstract

BackgroundOsteoporosis is a major health problem worldwide, and is included in the WHO list of the top 10 major diseases. However, it is often undiagnosed until the first fracture occurs, due to inadequate patient education and lack of insurance coverage for screening tests. Anamnestic risk factors like positive family anamnesis or early menopause are assumed to correlate with reduced BMD.MethodsIn our study of 78 patients with metaphyseal long bone fractures, we searched for a correlation between anamnestic risk factors, bone specific laboratory values, and the bone morphogenic density (BMD). Each indicator was examined as a possible diagnostic instrument for osteoporosis. The secondary aim of this study was to demonstrate the high prevalence of osteoporosis in patients with metaphyseal fractures.Results76.9% of our fracture patients had decreased bone density and 43.6% showed manifest osteoporosis in DXA (densitometry) measurements. Our questionnaire, identifying anamnestic risk factors, correlated highly significantly (p = 0.01) with reduced BMD, whereas seven bone-specific laboratory values (p = 0.046) correlated significantly.ConclusionsAnamnestic risk factors correlate with pathological BMD. The medical questionnaire used in this study would therefore function as a cost-effective primary diagnostic instrument for identification of osteoporosis patients.

Age impact on clinical risk factors does not justify the age related change in referral pattern for osteoporosis assessment—Data from the Aalborg University Hospital Record for Osteoporosis Risk Assessment (AURORA)

“…The clinical questionnaire approach provides a reliable estimate of the risk of osteoporosis [28] and of fracture risk [29] and it has been used as a valid tool in a number of settings [12,13]. Thus, we adopted this approach in the osteoporosis clinic in North Denmark.…”

Epidemiological investigation of hospitalized patients with traumatic fractures: a cross-sectional study

“…21 In addition, long-term alcohol consumption can alter bone metabolism, resulting in osteoporosis and decreased bone strength. 22 – 24 Therefore, reducing alcohol consumption helps to avoid the occurrence of traumatic fracture. The proportion of traffic accidents that caused injuries in 2014 (20.4%) 3 was significantly lower than that in 2012 (23.11%) and 2013 (23.14%).…”

Investigation and management of osteoporosis in aged trauma patients: a treatment algorithm adapted to the German guidelines for osteoporosis

“…Specific risk questionnaires are a reliable and cost-effective method of determining the individual risk [7]. The individual risk of fractures can be determined reliably from the evidence-based risk factors.…”