Anaphylactoid Reaction to an Initial Dose of Sodium Cephalothin

Cephalexin

“…Kabins et al, 1965;Thorburn et al, 1966;Scholand et al, 1968;Petz, 1971). Kabins et al, 1965;Thorburn et al, 1966;Scholand et al, 1968;Petz, 1971).…”

Cephaloridine in Gonorrhoea and Syphilis

“…However, Brandriss, Smith, and Steinman (1964) have demonstrated in rabbits that a cross-reaction may occur through a different chemical re-arrangement involving the fl-lactam ring which is fused with the penicillin as well as the cephalosporin nucleus. It is possible that this unusual mechanism was responsible for the allergic reaction to cephaloridine in our penicillin-sensitized patient, and in the patient reported by Kabins, Eisenstein, and Cohen (1965), who had an immediate anaphylactoid reaction to an initial dose of 500mg. sodium cephalothin 3 weeks after an injection of 600,000 units penicillin G. On the other hand, many patients known to be sensitized to penicillin were treated with either cephalothin (seven in the series of Griffith and Black, 1964) or cephaloridine (two in the series of Seftel, 1965) with no adverse reactions ensuing; also Stewart and Holt (1964) administered cephaloridine intradermally to five subjects with proven cutaneous hypersensitivity to penicillin and there were no local or systemic reactions.…”

Cephalothin Hypersensitivity Associated with Anti-Cephalothin Antibodies

“…In 5 of the 7 cases of cephalothin hypersensitivity, the allergic reactions occurred less than two days after the initiation of therapy. Several other cases in which an allergic reaction occurred within minutes or hours of an initial dose of cephalo thin in penicillin-allergic patients have been described [19][20][21][22].…”