Anaphylactoid Response to Thiopentone

Sustained-Release Drug Delivery System I: Coated Ion-Exchange Resin System for Phenylpropanolamine and Other Drugs

“…The resulting ion exchange is reversible and stoichiometric, with the displacement of one ionic species by another on the exchanger (1). The commercial availability of insoluble exchange resins having one functional group caught the attention of pharmaceutical scientists and resulted in several patents (2)(3)(4)(5)(6)(7)(8)(9)(10).…”

“…Borodkin and Sundberg (7,8) coated 72-147-pm particles of polymethacrylic acidion-exchange complexes of basic drugs with an ethylcellulose-hydroxypropyl methylcellulose (4:l) mixture using an air suspension coater to overcome the bitterness of the drugs. Clark (9) applied the enteric-coating agent cellulose acetate phthalate on 0.1-1-mm diameter pellets of cation-exchange adsorbate of drugs in a coating pan. No dissolution data were presented.…”

Correspondence

“…Unfortunately, we are not sure which drug caused the reaction. Thiopentone reactions are more commonly reported in the literature (Clark and Cockburn 1971). However, Lopert (1953), Walmsley (1959) and Hainsworth and Bingham (1970) have recorded allergic responses to gallamine.…”