Anaphylaxis to thiamine (vitamin B<sub>1</sub>)

Fernández, Maribel; Barceló, Montserrat; Muñoz, Candelaria; Torrecillas, M.; Blanca, Miguel

doi:10.1111/j.1398-9995.1997.tb01258.x

Cited by 24 publications

(4 citation statements)

References 6 publications

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“…Cases of anaphylactic shock have also been seen in patients with positive skin tests to vitamin B 1 (Pollit, 1968;Wrenn et al, 1989) and a case of reaction during desensitization has been reported (Mitrani, 1944). More recently, a patient was studied who had an IgEspecific anaphylactic response induced by thiamine (Fernandez et al, 1997). Leung et al (1993) investigated two patients who had anaphylaxis to parenteral thiamine and demonstrated positive skin tests and positive oral challenge in one patient.…”

Section: What Was the Basis Of Csm Recommendations?mentioning

confidence: 99%

The Royal College of Physicians Report on Alcohol: Guidelines for Managing Wernicke's Encephalopathy in the Accident and Emergency Department

Thomson¹

2002

Alcohol and Alcoholism

349

310

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The Royal College of Physicians (London) recently published its latest report on alcohol misuse entitled 'Alcohol - Can the NHS Afford It?'. Part of this document, encompassing our views, has made specific recommendations for the management of patients in the Accident and Emergency (A&E) Department who may possibly have, or are at risk of developing, Wernicke's encephalopathy. Patients showing evidence of chronic alcohol misuse and suspected of having a poor diet should be treated at the outset with B vitamins intravenously or intramuscularly, especially when the clinical signs are initially masked by drunkenness at presentation to the A&E Department. This commentary offers a review of the scientific foundations on which these recommendations have been made.

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Section: What Was the Basis Of Csm Recommendations?mentioning

confidence: 99%

The Royal College of Physicians Report on Alcohol: Guidelines for Managing Wernicke's Encephalopathy in the Accident and Emergency Department

Thomson¹

2002

Alcohol and Alcoholism

349

310

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“…Other drugs that can elicit DIA include proton pump inhibitors [29, 30•], quinolones [31], heparins [32], codeine [33], amiodarone [34], N-acetyl cysteine [35], chlorhexidine [36], vitamins [37][38][39] and corticoids [40][41][42]. Many of these drugs are frequently prescribed and cannot be easily substituted, warranting further study of these reactions.…”

Section: Epidemiology and Drugs Involvedmentioning

confidence: 99%

Drug-Induced Anaphylaxis

Blanca‐López

Plaza-Serón

Cornejo-García

et al. 2015

Curr Treat Options Allergy

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“…Es wurde ein primär Histamin-vermittelter Prozess angenommen. Drittens existieren aus jüngere Zeit einzelne Fallberichte, bei denen Thiamin-spezifische IgE-Antikörper in Patienten mit möglicherweise Thiamin-induzierten anaphylaktischen Reaktionen nachgewiesen wurden [26,27].…”

Section: Nebenwirkungen ± Die Gefürchtete Anaphylaxieunclassified

Die Thiaminbehandlung in der Psychiatrie und Neurologie

Hinze-Selch¹,

Weber²,

Zimmermann³

et al. 2000

Fortschr Neurol Psychiatr

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Every physician knows that alcohol dependence, alcohol withdrawal and Wernicke-Korsakow-syndrome require substitution with thiamine, in acute stages even parenterally. This would be trivial if there was not the widespread fear of anaphylactic, even lethal reactions to parenteral thiamine application. The present article reviews the literature published on thiamine since 1936, when the first synthetic, parenteral thiamine preparation became available, and, on this basis, tries to give practical advice and therapeutic regimens for the treatment of thiamine deficiency states. Controlled clinical studies on indications and differential thiamine therapy have not been published. From the data that are available, the following conclusions can be drawn: 1) Acute mortality of Wernicke-Korsakow-syndrome is about 20%. 2) Oral thiamine is safe. 3) The risk for an anaphylactic shock due to parenteral thiamine administration is below 1 to 100,000. 4) Not only alcohol but any condition with either increased metabolic need (pregnancy, consuming diseases) or deficient nutrition (including eating disorders) can lead to thiamine deficiency. Therefore, we suggest: 1) Oral thiamine substitution with at least 50 mg per day and supply of a sufficient and complete diet should be given to any person that might be at risk for thiamine deficiency. 2) Any patient suspicious for acute thiamine deficiency needs to be treated under inpatient conditions and there needs to receive 50 to 100 mg thiamine intravenously 3 to 4 times a day. 3) General practitioners, psychiatrists and neurologists should take care of the oral supplementation of thiamine, sufficient nutrition, and they are the physicians to diagnose early stages of thiamine deficiency.

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Anaphylaxis to thiamine (vitamin B₁)

Cited by 24 publications

References 6 publications

The Royal College of Physicians Report on Alcohol: Guidelines for Managing Wernicke's Encephalopathy in the Accident and Emergency Department

The Royal College of Physicians Report on Alcohol: Guidelines for Managing Wernicke's Encephalopathy in the Accident and Emergency Department

Drug-Induced Anaphylaxis

Die Thiaminbehandlung in der Psychiatrie und Neurologie

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Anaphylaxis to thiamine (vitamin B1)

Cited by 24 publications

References 6 publications

The Royal College of Physicians Report on Alcohol: Guidelines for Managing Wernicke's Encephalopathy in the Accident and Emergency Department

The Royal College of Physicians Report on Alcohol: Guidelines for Managing Wernicke's Encephalopathy in the Accident and Emergency Department

Drug-Induced Anaphylaxis

Die Thiaminbehandlung in der Psychiatrie und Neurologie

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Product

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Anaphylaxis to thiamine (vitamin B₁)