Anaplastic ganglioglioma of the brain stem demonstrating active neurosecretory features of neoplastic neuronal cells

Hirose, Takanori; Kannuki, Seiji; Nishida, Kenki; Matsumoto, Kozo; Sendo, Toshiaki; Hizawa, Kazuo

doi:10.1007/bf00713527

Cited by 40 publications

(32 citation statements)

References 26 publications

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“…10,[12][13][14][15]18) Previous cases manifested anaplastic histological features at initial resection. [1][2][3][4]8,9,11,[16][17][18]23,24) In our case, hypercellularity, mitotic figures, and endothelial proliferation were present in the astrocytic component, and thus satisfied the anaplastic criteria. Additionally, the short duration of clinical manifestation suggests de novo tumor anaplasia.…”

Section: Discussionmentioning

confidence: 69%

“…Malignant variants of ganglioglioma have been reported, [1][2][3][4]6,[8][9][10][11][12][13][14][15][16][17][18]20,21,23,24) but the incidence remains unknown. Two of 63 gangliogliomas were World Health Organization grade III 17) and three anaplastic variants were identified among 61 gangliogliomas.…”

Section: Discussionmentioning

confidence: 99%

“…21) Table 1 lists 10 cases of anaplastic gangliogliomas for which clinical details were provided. [1][2][3][4][5][7][8][9]18,23) Six patients died of tumor progression within 5 to 26 months after the initial diagnosis. We suggest that such anaplastic tumors exhibit aggressive biological behavior.…”

Section: Discussionmentioning

confidence: 99%

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Anaplastic Ganglioglioma of the Cerebellopontine Angle-Case Report-

Matsuzaki

Uno

Kageji

et al. 2005

Neurol. Med. Chir.(Tokyo)

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A 64-year-old woman presented with a rare anaplastic ganglioglioma in the right cerebellopontine angle manifesting as dizziness persisting for 2 weeks. Preoperative magnetic resonance (MR) imaging revealed a partially enhanced cystic lesion of the right cerebellopontine angle. The tumor was subtotally removed through a right lateral suboccipital craniectomy. The tumor was thought to originate from the brain stem with exophytic growth into the right cerebellopontine angle. Histological examination showed neoplastic ganglional and glial cells with anaplastic features such as mitosis, pleomorphism, and endothelial proliferation. The MIB-1 labeling index of the glial components was 40% to 60%. The diagnosis was anaplastic ganglioglioma (World Health Organization grade IV). She received postoperative radiotherapy but died of respiratory failure with tumor recurrence 11 months after the operation. Gangliogliomas usually have a good prognosis. Histological features of anaplasia and a high MIB-1 labeling index may be predictive of a poor clinical outcome.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

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Anaplastic Ganglioglioma of the Cerebellopontine Angle-Case Report-

Matsuzaki

Uno

Kageji

et al. 2005

Neurol. Med. Chir.(Tokyo)

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“…The sympathetic axon terminals are forming synapses together with the chromaffin cells where these synapses are positioned locations opposite and distant to the sinusoids. These sinusoids in turn are arranged via a branched construct of cells called the fenestrated endothelium and elapse to both the central medullar vein and the Hilary suprarenal vein, while according to the knowledge available until now the suprarenal medulla presence and function do not represent a necessity for life activities [57,58].…”

Section: Neuroblastoma -Current State and Recent Updatesmentioning

confidence: 99%

Anatomic Origin and Molecular Genetics in Neuroblastoma

Tosun¹,

Karabekir²,

Durmaz³

et al. 2017

Neuroblastoma - Current State and Recent Updates

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Neuroblastoma is considered as the most common extracranial solid tumor occurring during childhood, but takes place rarely after the age of 10 years. The tumors are considered as embryonal tumors that result from the fetal or early postnatal life development and are formed from neural crest-derived cells, and their origination is from the early nerve cells which are called as neuroblasts of sympathetic nervous system. Being heterogeneous in their biological, genetic, and morphological characteristics, tumors which are distinct from other solid tumors due to their biological heterogeneity result in the clinical pattern changes from spontaneous regression to a highly aggressive metastatic disease. Neuroblastoma tumorigenesis is regulated by Myc oncogene, leading to aggressive tumor subset. Many epigenetic factors play crucial role in the disease induction and development, while regulatory effect and outcome result in epigenetic patterns distinguishing neuroectoderm, neural crest, and more mature neural states. Neuroblastoma patients' clinical management is based on prognostic categories subtracted from studies correlating outcome and clinico-biological variables. Neuroblastoma anatomic boundaries include primarily autonomic nervous system besides other rare locations. Neuroblastoma molecular pathogenesis classifies the tumor according to the different clinical behaviors that are important for the improvement of the patients outcome and overall survival according to the different therapy modalities applied.

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“…Hirose et al [13] found varying No systematic examination has been undertaken to determine whether proliferation markers are predictive of more aggressive behavior in patients with gangliogliomas [13].…”

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confidence: 99%

Malignant transformation of grade II ganglioglioma to glioblastoma: A case report

Čupić¹,

Sajko²,

Sesar³

et al. 2012

Translational Neuroscience

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A 42-year-old woman was admitted to the hospital due to headaches and speech However, some of these tumors disclose histologically more malignant glial component and correspond to grade II or grade III tumors. We report a case of left temporal lobe tumor in a 42-year-old woman fulfilling the diagnostic criteria for atypical (grade II) ganglioglioma with high Ki-67 proliferation index and p53 immunoreactive tumor cells. In spite of gross total removal of the tumor, it recurred eight months after surgery. Histopathological examination of the recurrent tumor revealed that it had undergone malignant transformation into a glioblastoma. This case indicates that gangliogliomas with high Ki-67 proliferating index and p53 immunoreactivity should be carefully monitored for recurrence and malignant progression regardless of their morphological grading and seemingly total surgical removal.

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Anaplastic ganglioglioma of the brain stem demonstrating active neurosecretory features of neoplastic neuronal cells

Cited by 40 publications

References 26 publications

Anaplastic Ganglioglioma of the Cerebellopontine Angle-Case Report-

Anaplastic Ganglioglioma of the Cerebellopontine Angle-Case Report-

Anatomic Origin and Molecular Genetics in Neuroblastoma

Malignant transformation of grade II ganglioglioma to glioblastoma: A case report

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