Anatomic markers for the retrospective and prospective evaluation of pathology involving the feto - placental and utero - placental circulatory systems inside human placenta. Forensic implications

Zimta, Daniel; Melinte, Petru Răzvan; Dincă, Ileana; Drăgoi, Gheorghe S.

doi:10.4323/rjlm.2012.19

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…Phenotype transformations that appear during placental genesis are anatomic markers, irreversibly stocked inside its vascular and/or villous structures (Dragoi et al , 2010; Zimta et al 2012 [9]; Melinte et al 2015 [10]; Fox 1967, [11], 1970 [12]). They assure the placenta role of information storage, regarding determinant factors of both fetalplacenta and maternal-placenta blood circulations perturbations.…”

Section: Discussionmentioning

confidence: 99%

Placenta - the “black box” for the evolution of gestation and evidence in forensic expertise of pregnancy

Melinte¹,

Drăgoi²,

Dincă³

et al. 2015

RJLM

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The authors highlight the informational value of placenta in the understanding of antepartum, intrapartum and postpartum pathology within the fetal-placenta-maternal biosystem. The study, conducted on 120 placentas, selected from 1450 term pregnancies, draw the attention over issues related to maternal, fetal and newborn pathology that undergo simultaneously with phenotype transformations of placental trophoblastic, vascular and fibrin structures. Macro-and microanatomic analysis was conducted on fetal-placenta and maternal-placenta circulatory systems in order to evaluate placental reaction synergisms in the presence of umbilical vascular thrombosis and/or massive intra-and perivillous fibrin substance deposition. Anatomic examination of placenta allows the understanding of physiopathological processes within the fetalplacenta-maternal system and provides objective evidences for forensic expertise in order to estimate the approximate age of local lesions, to assess perinatal asphyxia and neurocongenital development perturbations.

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Section: Discussionmentioning

confidence: 99%

Placenta - the “black box” for the evolution of gestation and evidence in forensic expertise of pregnancy

Melinte¹,

Drăgoi²,

Dincă³

et al. 2015

RJLM

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“…On the next day, the sections were washed in 1× PBS, and a species-specific Horseradish Peroxidase (HRP)-labeled secondary antibody was added for one hour [ImmPRESS™ HRP Goat Anti-Mouse Immunoglobulin G (IgG) (Peroxidase) Polymer Detection Kit, Vector Lab]. After further washing in PBS, the signal was detected with 3,3’-Diaminobenzidine (DAB; Histofine ® DAB-3S kit), and finally the slides were briefly counterstained with Mayer’s Hematoxylin, dehydrated, cleared, and placed under the coverslip with a Xylene-based mounting medium (Sigma-Aldrich) [ 15 , 16 , 17 ].…”

Section: ⧉ Materials and Methodsmentioning

confidence: 99%

Calcium fructoborate coating of titanium–hydroxyapatite implants by chemisorption deposition improves implant osseointegration in the femur of New Zealand White rabbit experimental model

Varut¹,

Melinte²,

Pîrvu³

et al. 2021

Rom J Morphol Embryol

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This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. ORIGINAL PAPERCalcium fructoborate coating of titanium-hydroxyapatite implants by chemisorption deposition improves implant osseointegration in the femur of New Zealand White rabbit experimental model RENATA-MARIA VĂRUŢ 1) , PETRU RĂZVAN MELINTE 2) , ANDREEA SILVIA PÎRVU 3) , OANA GÎNGU 4) , GABRIELA SIMA 4) , CARMEN NICOLETA OANCEA 5) , ALINA CRISTINA TEIŞANU 4) , GHEORGHE DRĂGOI 6) , ANDREI BIŢĂ 7,8) , HORIA OCTAVIAN MANOLEA 9) , IOANA MITRUŢ 3,9) , OTILIA CONSTANTINA ROGOVEANU 10) , ION ROMULUS SCOREI 8) , JOHNY NEAMŢU 11)

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“…The evaluation of these "potentially toxic" levels is still unknown, as long as the fetal pharmacokinetics and the fetal pharmacodynamics are also unknown [9]. Maternal and/or fetal blood flow can be altered during gestation, in the context of umbilical cord anatomic variations (length, hypo-or hypercoiling), the thrombosis of subchorial vessels and the structure of perivillous fibrin deposition [10].…”

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confidence: 99%

A rare case of fatal materno-fetal methanol poisoning. Volatile congeners analysis as forensic evidence

Jung¹,

Idor²,

Bucur³

et al. 2014

RJLM

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Background. Methanol intoxication may be the result of either accidental or intentional ingestion, in case of substantial exposures coma and death may occur. Methanol poisoning during human pregnancy was rarely described. Material and method. We present the case of a 39-years old pregnant woman hospitalized for severe methanol intoxication. We reviewed the entire hospital medical documentation and performed blood and gastric content analysis for alcohol congeners using validated headspace-gaschromatography method (samples collected at admission from mother and at autopsy from fetus); we also examined all organs of the mother and of the stillborn, including microscopic sections stained with haematoxylin-eosin. Results and discussions. The 34 weeks pregnant patient was transported to the hospital due to respiratory distress, lethargy and coma. Laboratory findings revealed metabolic acidosis with anion gap. At presentation intrauterine fetal death was diagnosed and the fetus was extracted next day. The woman died after four days in hospital. At post-mortem examination we found marked brain edema, brain stem hemorrhages, focal bleedings in the white matter of the temporal and parietal lobes, leptomeningeal hyperaemia, kidneys with tubular necrosis and hemorrhages in renal cortex. Autopsy of the fetus revealed only leptomeningeal hyperaemia, suggesting a rapid death. Blood ethanol concentration was 1.03 g/l in mother and 1.98 g/l in foetus while methanol concentration was 1.72 g/l and 1.99 g/l respectively. Relatively high amounts of amyl-alcohol (2-methyl 1-butanol) in both samples indicate consumption of fruit distillate, while toxic blood methanol concentration can be explained only by contaminated beverage consumption. Conclusions. Intrauterine fetal death may occur without important morphological lesions in case of methanol transplacentar intoxication. Methanol is rapidly transferred to the fetus and cumulates in fetal circulation, while in case of other volatile congeners the transfer through the placental barrier seems to be selective.

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Anatomic markers for the retrospective and prospective evaluation of pathology involving the feto - placental and utero - placental circulatory systems inside human placenta. Forensic implications

Cited by 4 publications

References 25 publications

Placenta - the “black box” for the evolution of gestation and evidence in forensic expertise of pregnancy

Placenta - the “black box” for the evolution of gestation and evidence in forensic expertise of pregnancy

Calcium fructoborate coating of titanium–hydroxyapatite implants by chemisorption deposition improves implant osseointegration in the femur of New Zealand White rabbit experimental model

A rare case of fatal materno-fetal methanol poisoning. Volatile congeners analysis as forensic evidence

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