Anatomic Study of the Central Core of the Cerebrum Correlating 7-T Magnetic Resonance Imaging and Fiber Dissection With the Aid of a Neuronavigation System

Carlos, Alarcon; Notaris, Matteo de; Palma, Kenneth; Sòria, Guadalupe; Weiss, Alessandro; Kassam, Amin; Prats-Galino, Alberto

doi:10.1227/neu.0000000000000271

Cited by 14 publications

(10 citation statements)

References 53 publications

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“…A requirement for performing the fibers dissection technique is the knowledge of the gross anatomic features of the brain, which can be gleaned from the available atlases and articles that explain in three-dimensional terms the positions of the inner structures of the brain. 45,47,48,49,50,51,52,53,57,58,59,60,61,62,63,65,68,69,74,75,77,78,79,80,81,85,86 Without this fundamental knowledge, the fine structures of the brain can be inadvertently destroyed during fiber dissection. Before dissection is begun, the course and any variations of the sulci and gyri should be studied.…”

Section: Methodsmentioning

confidence: 99%

“…The fibers of the medial forebrain bundle emerge from the hypothalamus, pass around the pre-commissural fornix, than they reunite into a thin bundle running dorsally and caudally under the thalamus. 75 Finally they bend downward at the level of the superior colliculus into the brainstem. At this level the medial lemniscus coming upward from its origin in the dorsal part of the medulla, constitute a thin lamina bending anteriorly and reaching the thalamus.…”

Section: Dissection Of the Medial Aspectmentioning

confidence: 99%

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Microsurgical anatomy of the amygdaloid body and its connections

et al. 2021

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Section: Methodsmentioning

confidence: 99%

Section: Dissection Of the Medial Aspectmentioning

confidence: 99%

Microsurgical anatomy of the amygdaloid body and its connections

et al. 2021

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“…By performing tractography on DTI data collected in post-mortem human brain, we are provided with a non-invasive method for validating tracts that could otherwise only be localized using techniques that are destructive to the tissue, including dissection, histological fiber visualization, and tracer methods ( Alarcon et al, 2013; Dyrby et al, 2007; Gutman et al, 2013; Leergaard et al, 2010; Ruest et al, 2011; Schmahmann et al, 2007 ). Tissue preservation is a powerful benefit, allowing for subsequent investigative techniques on otherwise undamaged tissue samples.…”

Section: Introductionmentioning

confidence: 99%

Improving diffusion-weighted imaging of post-mortem human brains: SSFP at 7T

et al. 2014

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Post-mortem diffusion imaging of whole, human brains has potential to provide data for validation or high-resolution anatomical investigations. Previous work has demonstrated improvements in data acquired with diffusion-weighted steady-state free precession (DW-SSFP) compared with conventional diffusion-weighted spin echo at 3 T. This is due to the ability of DW-SSFP to overcome signal-to-noise and diffusion contrast losses brought about by tissue fixation related decreases in T2 and ADC. In this work, data of four post-mortem human brains were acquired at 3 T and 7 T, using DW-SSFP with similar effective b-values (beff ~ 5150 s/mm2) for inter-field strength comparisons; in addition, DW-SSFP data were acquired at 7 T with higher beff (~ 8550 s/mm2) for intra-field strength comparisons. Results demonstrate that both datasets acquired at 7 T had higher SNR and diffusion contrast than data acquired at 3 T, and data acquired at higher beff had improved diffusion contrast than at lower beff at 7 T. These results translate to improved estimates of secondary fiber orientations leading to higher fidelity tractography results compared with data acquired at 3 T. Specifically, tractography streamlines of cortical projections originating from the corpus callosum, corticospinal tract, and superior longitudinal fasciculus were more successful at crossing the centrum semiovale and projected closer to the cortex. Results suggest that DW-SSFP at 7 T is a preferential method for acquiring diffusion-weighted data of post-mortem human brain, specifically where the primary region of interest involves crossing white matter tracts.

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“…21,34,37,39,[65][66][67] Some fiber dissection studies have also been performed to describe STN anatomy. 1,12,64 However, no study in the literature has combined 3D MRI reconstruction with generalized qsampling imaging (GQI) tractography and sectional anatomy of the STN through the fiber dissection technique. We aimed to elucidate the 3D anatomy of the STN and related structures using the fiber dissection technique, 3D reconstruction of high-resolution MRI, and GQI tractography.…”

mentioning

confidence: 99%

Microsurgical anatomy of the subthalamic nucleus: correlating fiber dissection results with 3-T magnetic resonance imaging using neuronavigation

Güngör

Baydin

Holanda

et al. 2019

Journal of Neurosurgery

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OBJECTIVE Despite the extensive use of the subthalamic nucleus (STN) as a deep brain stimulation (DBS) target, unveiling the extensive functional connectivity of the nucleus, relating its structural connectivity to the stimulation-induced adverse effects, and thus optimizing the STN targeting still remain challenging. Mastering the 3D anatomy of the STN region should be the fundamental goal to achieve ideal surgical results, due to the deep-seated and obscure position of the nucleus, variable shape and relatively small size, oblique orientation, and extensive structural connectivity. In the present study, the authors aimed to delineate the 3D anatomy of the STN and unveil the complex relationship between the anatomical structures within the STN region using fiber dissection technique, 3D reconstructions of high-resolution MRI, and fiber tracking using diffusion tractography utilizing a generalized q-sampling imaging (GQI) model. METHODS Fiber dissection was performed in 20 hemispheres and 3 cadaveric heads using the Klingler method. Fiber dissections of the brain were performed from all orientations in a stepwise manner to reveal the 3D anatomy of the STN. In addition, 3 brains were cut into 5-mm coronal, axial, and sagittal slices to show the sectional anatomy. GQI data were also used to elucidate the connections among hubs within the STN region. RESULTS The study correlated the results of STN fiber dissection with those of 3D MRI reconstruction and tractography using neuronavigation. A 3D terrain model of the subthalamic area encircling the STN was built to clarify its anatomical relations with the putamen, globus pallidus internus, globus pallidus externus, internal capsule, caudate nucleus laterally, substantia nigra inferiorly, zona incerta superiorly, and red nucleus medially. The authors also describe the relationship of the medial lemniscus, oculomotor nerve fibers, and the medial forebrain bundle with the STN using tractography with a 3D STN model. CONCLUSIONS This study examines the complex 3D anatomy of the STN and peri-subthalamic area. In comparison with previous clinical data on STN targeting, the results of this study promise further understanding of the structural connections of the STN, the exact location of the fiber compositions within the region, and clinical applications such as stimulation-induced adverse effects during DBS targeting.

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Anatomic Study of the Central Core of the Cerebrum Correlating 7-T Magnetic Resonance Imaging and Fiber Dissection With the Aid of a Neuronavigation System

Abstract: The correlation of high-definition 7-T MRI and the white matter dissection technique with neuronavigation significantly improves the understanding of the structural connections in complex areas of the human cerebrum.

Cited by 14 publications

References 53 publications

Microsurgical anatomy of the amygdaloid body and its connections

Microsurgical anatomy of the amygdaloid body and its connections

Improving diffusion-weighted imaging of post-mortem human brains: SSFP at 7T

Microsurgical anatomy of the subthalamic nucleus: correlating fiber dissection results with 3-T magnetic resonance imaging using neuronavigation

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