Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Desgranges, Béatrice; Matuszewski, Vanessa; Piolino, Pascale; Chételat, Gaël; Mézenge, Florence; Landeau, Brigitte; Sayette, Vincent de La; Belliard, Serge; Eustache, Francis

doi:10.1016/j.neurobiolaging.2006.08.006

Cited by 140 publications

(100 citation statements)

References 78 publications

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“…77 ALS and FTD patients have been found to present with semantic memory deficits. 47,49,62,105,106 Still in the semantic domain, deficits in linguistic abilities and social communication have been recently reported in ALS patients found with structural and functional temporal lobe changes. 47,90,107,108 Phukan and colleagues 102 found that 14% of non-demented ALS patients presented with cognitive impairment, including language deficits, but without executive dysfunction.…”

Section: Clinical/neuropsychological Findingsmentioning

confidence: 98%

“…41,60 In SD, hypometabolism was found in anterior poles, hippocampal region and fusiform gyrus. [61][62][63] Despite specific patterns of atrophy in each of the syndromes, ALS and FTD show many common areas of atrophy. Taken together, these imaging findings support the notion that ALS and FTD overlap in their neural correlates although some regions may be more affected than others in each of the diseases.…”

Section: Functional Imagingmentioning

confidence: 99%

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How predictive are temporal lobe changes of underlying TDP-43 pathology in the ALS-FTD continuum?

Bueno

Bertoux

Souza

et al. 2017

Ann Clin Neurophysiol

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Detection of underling proteinopathies is becoming increasingly important across neurodegenerative conditions due to upcoming disease intervention trials. In this review, we explored how temporal lobe changes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) can potentially predict underlying TDP-43 pathology subtypes in FTD. To date, emphasis has been given to frontal lobe changes in the study of the cognitive and behavioural impairments in both syndromes but an increasing number of pathological, imaging and neuropsychological studies suggest how temporal lobe changes could critically affect the cognition and behaviour of these conditions. In this current article, we reviewed pathological, imaging as well as clinical/neuropsychological findings of temporal involvement in the ALS-FTD continuum, how they relate to temporal lobe changes and the underlying TDP-43 pathology in FTD. Findings across studies show that TDP-43 pathology occurs and coincides in many structures in ALS and FTD, but especially in the temporal lobes. In particular, anterior and medial temporal lobes atrophy is consistently found in ALS and FTD. In addition, memory and language impairment as well as emotional and Theory of Mind processing deficits that are characteristics of the two diseases are highly correlated to temporal lobe dysfunction. We conclude by showing that temporal lobe changes due to TDP-43 type B might be particular predictive of TDP-43 type B pathology in behavioural variant FTD, which clearly needs to be investigated further in the future.

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Section: Clinical/neuropsychological Findingsmentioning

confidence: 98%

Section: Functional Imagingmentioning

confidence: 99%

How predictive are temporal lobe changes of underlying TDP-43 pathology in the ALS-FTD continuum?

Bueno

Bertoux

Souza

et al. 2017

Ann Clin Neurophysiol

View full text Add to dashboard Cite

show abstract

“…By putting both imaging modalities on the same measurement scale (z-scores) and adjusting for difference in resolution between modalities (differential smoothing; 14 method described in the 'Materials and methods' section), it is possible to compare structural and metabolic deficits, as already done in several other studies 15,16 and even in other imaging modalities (AV45 16 ). Such an approach provides a deeper understanding of the different brain alterations and the pathological mechanisms underlying the disease as conducted in Alzheimer's disease (AD), semantic dementia 15 and Korsakoff's syndrome. 17 In AD, two distinct profiles were found: (a) atrophy exceeding hypometabolism in medial temporal lobe and hippocampus and (b) more severe hypometabolism than GM atrophy in posterior associative areas that may have precede structural changes.…”

Section: Introductionmentioning

confidence: 99%

Direct voxel-based comparisons between grey matter shrinkage and glucose hypometabolism in chronic alcoholism

Ritz

Segobin

Lannuzel

et al. 2016

J Cereb Blood Flow Metab

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Alcoholism is associated with widespread brain structural abnormalities affecting mainly the frontocerebellar and the Papez's circuits. Brain glucose metabolism has received limited attention, and few studies used regions of interest approach and showed reduced global brain metabolism predominantly in the frontal and parietal lobes. Even though these studies have examined the relationship between grey matter shrinkage and hypometabolism, none has performed a direct voxel-by-voxel comparison between the degrees of structural and metabolic abnormalities. Seventeen alcoholic patients and 16 control subjects underwent both structural magnetic resonance imaging and 18 F-2-fluoro-deoxy-glucosepositron emission tomography examinations. Structural abnormalities and hypometabolism were examined in alcoholic patients compared with control subjects using two-sample t-tests. Then, these two patterns of brain damage were directly compared with a paired t-test. Compared to controls, alcoholic patients had grey matter shrinkage and hypometabolism in the fronto-cerebellar circuit and several nodes of Papez's circuit. The direct comparison revealed greater shrinkage than hypometabolism in the cerebellum, cingulate cortex, thalamus and hippocampus and parahippocampal gyrus. Conversely, hypometabolism was more severe than shrinkage in the dorsolateral, premotor and parietal cortices. The distinct profiles of abnormalities found within the Papez's circuit, the fronto-cerebellar circuit and the parietal gyrus in chronic alcoholism suggest the involvement of different pathological mechanisms.

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“…Neuropsychological studies reported that lesions in the anterior region caused amnesia of broad categories of knowledge (Mummery et al, 2000;Chan et al, 2001;Desgranges et al, 2007). Other studies using semantic dementia patients commonly reported lesions in the anterior temporal lobe (Davies et al, 2004;Nestor et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Functional Dissociation between Anterior and Posterior Temporal Cortical Regions during Retrieval of Remote Memory

Watanabe¹,

Kimura²,

Hirose³

et al. 2012

Journal of Neuroscience

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Retrieval of remote memory is considered to differentially involve the anterior and posterior temporal neocortices. Previous neuropsychological studies suggest that the different posterior temporal cortical regions are involved in the retrieval of remote memory of different categories of stimuli, whereas the anterior region is involved more generally in remote memory retrieval. In the present study, using functional magnetic resonance imaging of human brains, we tested this dissociation by examining the more precise characteristics of the anterior and posterior temporal cortical regions. Two categories of stimuli, faces and scenes, were used for paired stimuli to be retrieved, and the brain activity during retrieval of paired stimuli that were learned immediately before the scanning was compared with that during retrieval of paired stimuli that were learned ϳ8 weeks earlier. We found that the different posterior temporal cortical regions were activated during retrieval of different categories of remote memory in a category-specific manner, whereas the anterior temporal cortical region was activated during retrieval of remote memory in a category-general manner. Furthermore, by applying a multivariate pattern analysis to psychophysiological interactions during retrieval of remote memory relative to recent memory, we revealed the significant interaction from the category-specific posterior temporal cortical regions to the category-general anterior temporal region. These results suggest that the posterior temporal cortical regions are involved in representation and retrieval of category-specific remote memory, whereas the anterior cortical temporal region is involved in category-general retrieval process of remote memory.

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Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Cited by 140 publications

References 78 publications

How predictive are temporal lobe changes of underlying TDP-43 pathology in the ALS-FTD continuum?

How predictive are temporal lobe changes of underlying TDP-43 pathology in the ALS-FTD continuum?

Direct voxel-based comparisons between grey matter shrinkage and glucose hypometabolism in chronic alcoholism

Functional Dissociation between Anterior and Posterior Temporal Cortical Regions during Retrieval of Remote Memory

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