Anatomical and functional brain variables associated with clozapine response in treatment-resistant schizophrenia

Magnetic Resonance Imaging Predictors of Treatment Response in First-Episode Schizophrenia

“…Temporal lobe regions have been critically implicated in the pathophysiology of schizophrenia 49,50 with some evidence that gray matter loss is associated with the transition to psychosis, 51 but the structural integrity of this region in mediating faster response to antipsychotic medications has not been well investigated. Our findings are consistent, however, with Molina and colleagues, 52 who reported that positive symptom improvement was associated with temporal lobe gray matter volume among treatment resistant patients receiving clozapine. Similarly, Woods et al 53 noted treatment-associated changes in temporal lobe regions among patients with schizophrenia-spectrum diagnoses using MR spectroscopy.…”

Identification of two clusters within schizophrenia with different structural, functional and clinical characteristics

“…After release they were treated and followed in an outpatient clinic. MRI data were collected over a 15-year period, in the context of several research projects (identification of cerebral correlates of treatmentresistance (Molina et al, 2003b), early stages (Molina et al, 2003a) of schizophrenia, differences between major psychoses (Molina et al, 2010a) and effects of antipsychotics on brain structure (Molina et al, 2005a)). …”

No Association between Dorsolateral Prefrontal Gray Matter Deficit and N-Acetyl Aspartate Ratios in Schizophrenia

“…Since age and total cranial size are known factors affecting regional cerebral volumes, their effect was removed by using the residuals from the regression models obtained from a group of healthy individuals (n = 50) from a previous study [24] , following the procedure of Pfefferbaum et al [25] . After this correction, volume variables are expressed as deviations from the expected volumes in healthy individuals of the same age and brain size as the patient.…”