Anatomical and microscopic study of the volar dermal ridges of the rat (<i>Rattus norvegicus</i>)

Okajima, M.; Asai, Yoshihiro

doi:10.1002/ajpa.1330670202

Cited by 22 publications

(23 citation statements)

References 2 publications

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“…In many non-primates, ridges are not manifested at the epidermal surface but are recognizable as undulations at the epidermal-dermal junction, as in the rat (Okajima and Asai, 1985;and unpublished data).…”

Section: Introductionmentioning

confidence: 83%

“…Examinations were made of the dermal surface, which was prepared by procedures modified from those reported previously (Okajima and Asai, 1985;Okajima and Newell-Morris, 1988).…”

Section: Stereoscopic Microscopy Preparation Of Dermal Surfacementioning

confidence: 99%

“…Merkel (1880) described the existence of ridged structures at the dermal surface of volar pads in the rat, but did not mention configurational ridge arrangements. Recently, I discovered that in the rat (Rattus noruegicus), the dermal ridges described by Merkel exhibit various types of dermatoglyphic configuration, especially on palmar interdigital pad 111, and that each inbred strain possesses characteristic patterns (Okajima and Asai, 1985). Therefore, experimental approaches to genetic and morphogenetic studies are now possible (Okajima and Yosida, 1986;Okajima et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

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Dermal ridge development on the volar pads of the rat (Rattus norvegicus) and comparative study of pattern formation using inbred strains

Okajima

1991

Am. J. Anat.

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The development of dermal ridges, ridge configurations, and volar pad contours was investigated in the volar skin of the rat (Rattus norvegicus). The ridged structures corresponding to the epidermal ridges of primates exist only at the epidermal-dermal junction in the rat. Dermal specimens were prepared by treatment with alkaline solution and examined by toluidine blue staining and scanning electron microscopy, together with histological sections. Differentiation of dermal ridges began on day 18 of gestation on the palm followed by the sole. Ridges increased in number with advancing age. The process was complete approximately 2-3 days after birth, and sweat ducts began to develop simultaneously. As dermal ridges present various configurational patterns on palmar interdigital pad III, pattern formation on this pad was inspected in fetuses of three inbred strains possessing different pattern types, and in the hybrid progeny derived from them. Patterns and pad forms appeared to be under genetic control. It was revealed that the ridge arrangements, i.e., whorls, triradii, comb-like patterns, and others, are closely related to the pad contours during the developmental period, as hypothesized in primates.

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Section: Introductionmentioning

confidence: 83%

“…Examinations were made of the dermal surface, which was prepared by procedures modified from those reported previously (Okajima and Asai, 1985;Okajima and Newell-Morris, 1988).…”

Section: Stereoscopic Microscopy Preparation Of Dermal Surfacementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dermal ridge development on the volar pads of the rat (Rattus norvegicus) and comparative study of pattern formation using inbred strains

Okajima

1991

Am. J. Anat.

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“…Scanning electron microscopy (SEM) has subsequently been used for obser vations of the dermal surface after treatment with alkali [Misumi and Akiyoshi. 1984;Okajima and Asai. 1985;Okajima and Newell-Morris, 1988] or ethylenediaminetetraacetic acid (EDTA) [Kawabe et al, 1985].…”

Section: Introductionmentioning

confidence: 99%

Scanning Electron Microscopy of the Basal Surface of the Epidermis of Human Digits

Yamada

Kashima²,

Inoue³

1996

Cells Tissues Organs

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The epidermal-dermal junction of the volar skin of human digits was examined by scanning electron microscopy (SEM). Fixed specimens obtained from cadavers were treated with 6 N NaOH to exfoliate the epithelium. The three-dimensional features of the basal surfaces were clearly visualized by SEM. Epithelial prolongations (intermediate and limiting ridges) protruded towards the dermis, and transverse ridges were visible between them. Nerve fibers and Schwann cells were aggregated around the sweat ducts on the intermediate ridges. Discoid structures were visible among the nerve fibers and Schwann cells. Examination by transmission electron microscopy of ultrathin sections of re-embedded specimens confirmed that the discoid structures were nerve endings that covered the Merkel cells. Minute projections were studded on the basal surfaces of basal keratinocytes. The projections in the intermediate ridges appeared to be villous, whereas the profiles of those in the limiting ridges resembled cobblestones. This morphological difference might be a reflection of function.

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“…The morphological terms for describing the major pads and flexion creases are essentially the same as those used for rats (Rattus norvegicus) (Brown and Yalden, 1973;Okajima and Asai, 1985;Okajima, 1991;Kimura et al, 1994), newborn rats , and field mice (Microtus) (Whipple, 1904). The palmar and plantar surfaces of mice and rats share morphological features, including pads and flexion creases.…”

Section: Methodsmentioning

confidence: 99%

Normal Location Of Thumb/Big Toe may be Related to Programmed Cell Death in the Preaxial Area of Embryonic Limb

Kimura

Yamada

2011

The Anatomical Record

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The forelimbs and hindlimbs of newborn Polydactyly Nagoya (Pdn) mice were examined to analyze the roles of programmed cell death (PCD) in the preaxial region of the limb. Special attention was paid to the relationship between the PCD in the preaxial area and the location and shape of the first digit (thumb/big toe). Although a large, bifurcated or duplicated thumb/big toe appeared in Pdn/þ mice, digit I (thumb/big toe) in Pdn/þ mice, as in þ/þ ones, was located more ventro-proximally than the other four digits. On the other hand, abnormal preaxial digits of the fore/hindlimb in Pdn/Pdn mice lay distally and were aligned at the radial/tibial end of a serial curved plane formed by digits II-V; that is, a thumb and big toe of normal shape and location were not detectable in any preaxial digits of Pdn/Pdn mice. In the limb development of Pdn mouse embryos on Day 11-12, PCD did not occur in the preaxial mesoderm of fore/hindlimb only in one-fourths of all embryos obtained by Pdn/þ x Pdn/þ mating. In addition to digital rays II-V, extra preaxial digital rays appeared in the prominent preaxial expansion of fore/hindlimbs in these embryos on early Day 12. These abnormal limb configurations in embryos were closely similar to those in Pdn/Pdn newborn mice. The present findings suggest that PCD in the preaxial region not only prevents the formation of extra digits but also determines the location of the thumb/big toe for the normal limb morphogenesis. Anat Rec, 294:1352Rec, 294: -1359Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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Anatomical and microscopic study of the volar dermal ridges of the rat (Rattus norvegicus)

Cited by 22 publications

References 2 publications

Dermal ridge development on the volar pads of the rat (Rattus norvegicus) and comparative study of pattern formation using inbred strains

Dermal ridge development on the volar pads of the rat (Rattus norvegicus) and comparative study of pattern formation using inbred strains

Scanning Electron Microscopy of the Basal Surface of the Epidermis of Human Digits

Normal Location Of Thumb/Big Toe may be Related to Programmed Cell Death in the Preaxial Area of Embryonic Limb

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