Oral Bioavailability 2011
DOI: 10.1002/9781118067598.ch16
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Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, and Humans

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Cited by 7 publications
(7 citation statements)
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References 108 publications
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“…The recognition motif for transport appears to be strict, as a considerably smaller fraction of the dose was absorbed for the structurally similar analog 7a . Owing to their small molecular weight and hydrophilic nature, paracellular absorption may be another route for the dicarboxylates to achieve moderate absorption . Similar and modest fa values were achieved after oral administration of compound 1 (racemic mixture) or 1a (single enantiomer), suggesting a passive mode of absorption such as paracellular for some of the analogues.…”
Section: Discussionmentioning
confidence: 85%
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“…The recognition motif for transport appears to be strict, as a considerably smaller fraction of the dose was absorbed for the structurally similar analog 7a . Owing to their small molecular weight and hydrophilic nature, paracellular absorption may be another route for the dicarboxylates to achieve moderate absorption . Similar and modest fa values were achieved after oral administration of compound 1 (racemic mixture) or 1a (single enantiomer), suggesting a passive mode of absorption such as paracellular for some of the analogues.…”
Section: Discussionmentioning
confidence: 85%
“…Owing to their small molecular weight and hydrophilic nature, paracellular absorption may be another route for the dicarboxylates to achieve moderate absorption. 15 Similar and modest fa values were achieved after oral administration of compound 1 (racemic mixture) or 1a (single enantiomer), suggesting a passive mode of absorption such as paracellular for some of the analogues. Renal clearance for most analogues evaluated in vivo was greater than rat GFR, implying active renal secretion, although no specific carriers were identified in this study.…”
Section: ■ Discussion and Conclusionmentioning
confidence: 93%
“…Active uptake may also play a role in gut absorption of 2 via intestinal solute carriers, such as NaDC1 31 . Due to its hydrophilicity and low molecular weight, paracellular absorption cannot be ruled out as another potential mechanism for oral absorption of 2 32 33 .…”
Section: Discussionmentioning
confidence: 99%
“…It is worth noting that a number of vaccines can enter the gastrointestinal tract during nasal immunization ( 56 , 57 ). A previous study developed a sheep model to detect the efficacy of nasal vaccine administration.…”
Section: Discussionmentioning
confidence: 99%