Anatomy and Physiology of Hair

Erdoğan, Bilgen

doi:10.5772/67269

Cited by 26 publications

(25 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hair follicle (HF) is the key organ for hair growth, and it consists of two distinct parts. The upper permanent region is comprised of the infundibulum and isthmus, which are relatively stable, whiles the lower follicle is comprised of the hair bulb and suprabulbar region, which undergo periodic regeneration [ 1 ]. Follicular papilla in the hair bulb dictates the induction and maintenance of the follicular epithelial differentiation, and determines anagen duration, hair shaft diameter and length [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…The upper permanent region is comprised of the infundibulum and isthmus, which are relatively stable, whiles the lower follicle is comprised of the hair bulb and suprabulbar region, which undergo periodic regeneration [ 1 ]. Follicular papilla in the hair bulb dictates the induction and maintenance of the follicular epithelial differentiation, and determines anagen duration, hair shaft diameter and length [ 1 , 2 ]. Hair follicles do not enter the self-renewal cycle until they are fully developed after birth, and experience growth (anagen), regression (catagen), and a rest period (telogen), followed hair shedding [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Identification of Key Pathways and Genes Related to the Development of Hair Follicle Cycle in Cashmere Goats

Wang

Sui

Mao

et al. 2021

Genes

View full text Add to dashboard Cite

The development of hair follicle in cashmere goats shows significant periodic change, as with mice and humans. However, for cashmere goat with double-coat, the periodic change may be due to other regulatory molecules and signal pathways. To understand the mechanism of periodic development of hair follicle, we performed a weighted gene coexpression network analysis (WGCNA) to mine key genes and establish an interaction network by utilizing the NCBI public dataset. Ten coexpression modules, including 7689 protein-coding genes, were constructed by WGCNA, six of which are considered to be significantly related to the development of the hair follicle cycle. A functional enrichment analysis for each model showed that they are closely related to ECM- receptor interaction, focal adhesion, PI3K-Akt signaling pathway, estrogen signaling pathway, and so on. Combined with the analysis of differential expressed genes, 12 hub genes from coexpression modules were selected as candidate markers, i.e., COL1A1, C1QTNF6, COL1A2, AQP3, KRTAP3-1, KRTAP11-1, FA2H, NDUFS5, DERL2, MRPL14, ANTKMT and XAB2, which might be applied to improve cashmere production.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification of Key Pathways and Genes Related to the Development of Hair Follicle Cycle in Cashmere Goats

Wang

Sui

Mao

et al. 2021

Genes

View full text Add to dashboard Cite

show abstract

“…The lower HF, including the hair bulge, of mutant animals was unaffected ( Fig.1G) but their sebaceous glands were significantly smaller, with a mean volume of 0.62*10 5 µm 3 compared to 0.89*10 5 µm 3 in controls ( were twice the size in mutants as compared to controls, with a mean volume of 1.6*10 5 µm 3 versus 0.8*10 5 µm 3 ( Fig.1H and J). Similar to Lrig1-Apc mice, the bulge and cycling lower portion of the HF (hair bulb) 28 of Lrig1-βcat mice were unaffected.…”

Section: Modulation Of Wnt Signalling Results In Contrasting Upper Hamentioning

confidence: 89%

Aberrant Wnt signalling induces comedo-like changes in the upper hair follicle

Shang¹,

Tan²,

Steensel³

et al. 2020

Preprint

View full text Add to dashboard Cite

Comedonal acne is a common skin disease characterized by cystic dilation of the hair follicle junctional zone. While the molecular mechanisms of acne pathogenesis are not well understood, an emerging hypothesis holds that imbalances in key signalling pathways may lead to abnormal fate determination of sebaceous progenitor cells. The subsequent accumulation of cells could then cause cyst formation in the hair follicle junctional zone and lower infundibulum, forming blackheads. This notion is supported by the observation that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes severe comedonic acne and seboatrophy by inducing fate changes in Lrig1-expressing stem cells, as well as recent human GWAS studies implicating the Wnt signalling pathway in acne. To test the possible involvement of Wnt signals in blackhead formation, we used an Lrig1-CreERT2 mouse line to modulate Wnt signalling in stem cells of the junctional zone, which are known to contribute to the junctional zone, infundibulum, and sebaceous glands. We find that persistent activation of Wnt signalling in the junctional zone leads to formation of comedone-like cysts with associated atrophic sebaceous glands. The cysts strongly express stem cell markers and can be partially reduced by treatment with all-trans retinoic acid, a well-established acne treatment, as well as by inhibition of Hedgehog signalling. In contrast, loss of Wnt signalling leads to enlargement of the junctional zone, infundibulum and sebaceous glands. These data lead us to suggest that abnormal Wnt signalling could be involved in acne pathogenesis by inhibiting differentiation and retaining junctional zone cells in a proliferative progenitor state, leading to their accumulation into comedones.

show abstract

“…10 Vellus hairs, which are defined as short, non-pigmented and generally nonmedullated hairs, were not found in the pig ear. 26 The length of the infundibulum of the hair follicles in the anagen phase varied depending on the total length of the hair follicle. Hair follicles <2000 μm had an infundibulum length of approximately 373 ± 72 μm, hair follicles >2000 μm provided a longer infundibulum, with an average length of 516 ± 107 μm.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the morphometric parameters of pig ear hair follicles

Zambrano

Klein

Patzelt

2021

Skin Research and Technology

View full text Add to dashboard Cite

Background: Porcine ear skin is used in studies of percutaneous penetration as a substitute for human skin. The objective of the present study was to determine the structure of the hair follicles on the dorsal area of porcine ear skin and make a morphometric comparison with the hair follicles of human skin. Materials and Methods:Sections of frozen biopsies were cut vertically to the skin surface in longitudinal sections using a cryotome and were investigated using microscopy. For each hair follicle, various parameters were determined. Results:The follicular density in porcine ear skin varies according to the area studied, and the length of most of the follicles was approximately 1458 ± 286 μm. The size of the follicular orifice was also determined in a total of 305 follicles. It showed a diameter of roughly 113 ± 43 μm. Conclusion:The results showed a very good similarity between human and pig hair follicles. Therefore, porcine ear skin can be considered as a very suitable model of human skin in dermal and especially follicular penetration studies.

show abstract

Anatomy and Physiology of Hair

Cited by 26 publications

References 40 publications

Identification of Key Pathways and Genes Related to the Development of Hair Follicle Cycle in Cashmere Goats

Identification of Key Pathways and Genes Related to the Development of Hair Follicle Cycle in Cashmere Goats

Aberrant Wnt signalling induces comedo-like changes in the upper hair follicle

Analysis of the morphometric parameters of pig ear hair follicles

Contact Info

Product

Resources

About