AnAzf1 acts as a positive regulator of ochratoxin A biosynthesis in Aspergillus niger

Shan, Wei; Hu, Chaojiang; Zhang, Yige; Lv, Yangyong; Zhang, Shuai-Bing; Zhai, Huan-Chen; Hu, Yuansen

doi:10.1007/s00253-023-12404-8

Cited by 8 publications

(1 citation statement)

References 53 publications

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“…The results of the research on A. niger performed by Wei et al, showed a valid role of the AnAzf1 gene. After its removal, OTA production was completely blocked and cluster of genes such as: p450, nrps, hal, and bzip was repressed at the transcriptional level [51]. The AcOTAbZIP gene is directly related to the expression of four other genes: AcOTApks, AcOTAp450, AcOTAnrps, and AcOTAhal.…”

Section: Biosynthesismentioning

confidence: 99%

Ochratoxin A—The Current Knowledge Concerning Hepatotoxicity, Mode of Action and Possible Prevention

Więckowska,

Szelenberger,

Niemcewicz

et al. 2023

Molecules

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Ochratoxin A (OTA) is considered as the most toxic of the other ochratoxins synthesized by various fungal species belonging to the Aspergillus and Penicillium families. OTA commonly contaminates food and beverages, resulting in animal and human health issues. The toxicity of OTA is known to cause liver damage and is still being researched. However, current findings do not provide clear insights into the toxin mechanism of action. The current studies focusing on the use of potentially protective compounds against the effects of the toxin are insufficient as they are mainly conducted on animals. Further research is required to fill the existing gaps in both fields (namely the exact OTA molecular mechanism and the prevention of its toxicity in the human liver). This review article is a summary of the so far obtained results of studies focusing on the OTA hepatotoxicity, its mode of action, and the known approaches of liver cells protection, which may be the base for expanding other research in near future.

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Section: Biosynthesismentioning

confidence: 99%