ANCA—pathophysiology revisited

Kallenberg, Cees G. M.; Brouwer, Elisabeth; Mulder, A. H. L.; Stegeman, Coen A.; Weening, Jan J.; Tervaert, Jan Willem Cohen

doi:10.1111/j.1365-2249.1995.tb03594.x

Cited by 42 publications

(7 citation statements)

References 25 publications

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“…Studies indicating the close link between granulomatosis with polyangiitis (Wegeners granulomatosis) and chronic nasal Staphylococcus aureus carriage were key in linking the development of ANCA with infection 10–12. Further work done on molecular mimicry,13 the role complementary PR314 15 and a new subset of ANCA, lysosomal-associated membrane protein 2,8 16 17 further serve to reinforce this link.…”

Section: Discussionmentioning

confidence: 91%

Complements do not lie

Robert¹,

Forbes²,

Soleimanian³

et al. 2011

Case Reports

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Section: Discussionmentioning

confidence: 91%

Complements do not lie

Robert¹,

Forbes²,

Soleimanian³

et al. 2011

Case Reports

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“…Mechanisms whereby the ANCA autoantibodies themselves may cause tissue injury have been proposed [6], but remain unproven. Whilst we firmly believe that SV has an autoimmune etiology, detailed knowledge of the precise cellular mechanisms involved continues to elude clinicians and scientists alike.…”

Section: Resultsmentioning

confidence: 99%

“…ANCA are highly sensitive and specific for active primary systemic vasculitides involving small blood vessels (Wegener's granulomatosis (WG), microscopic polyangiitis) [5]. As well as their undoubted clinical utility it is possible that ANCA also play a role in pathogenesis [6]. Following this description of humoral autoreactivity in SV, it was natural to ask whether autoreactive T cells were also present.…”

Section: Introductionmentioning

confidence: 99%

The role of cellular immunity in systemic vasculitis

Mathieson

Oliveira

1995

Clinical and Experimental Immunology

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“…The mechanism underlying retinal vasculitis in WG remains unknown; the pathogenesis can be inferred by vasculitis mediated, in part, by stimulatory autoantibodies (ANCA). This process causes the neutrophils to bind to endothelium and to release mediators that injure the vessel wall [ 7 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Central retinal artery occlusion in Wegener's granulomatosis: a diagnostic dilemma

Lozano-López

Rodríguez-Lozano

Losada-Castillo

et al. 2011

J Ophthal Inflamm Infect

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PurposeTo report a case of central retinal artery occlusion (CRAO) in a patient with biopsy-verified Wegener's granulomatosis (WG) with positive C-ANCA.MethodsA 55-year-old woman presented with a 3-day history of acute painless bilateral loss of vision; she also complained of fever and weight loss. Examination showed a CRAO in the left eye and angiographically documented choroidal ischemia in both eyes.ResultsThe possibility of systemic vasculitis was not kept in mind until further studies were carried out; methylprednisolone pulse therapy was then started. Renal biopsy disclosed focal and segmental necrotizing vasculitis of the medium-sized arteries, supporting the diagnosis of WG, and cyclophosphamide pulse therapy was administered with gradual improvement, but there was no visual recovery.ConclusionCRAO as presenting manifestation of WG, in the context of retinal vasculitis, is very uncommon, but we should be aware of WG in the etiology of CRAO. This report shows the difficulty of diagnosing Wegener's granulomatosis; it requires a high index of suspicion, and we should obtain an accurate medical history and repeat serological and histopathological examinations. It emphasizes that inflammation of arteries leads to irreversible retinal infarction, and visual loss may occur

show abstract

ANCA—pathophysiology revisited

Cited by 42 publications

References 25 publications

Complements do not lie

Complements do not lie

The role of cellular immunity in systemic vasculitis

Central retinal artery occlusion in Wegener's granulomatosis: a diagnostic dilemma

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