ANCA Testing in Clinical Practice: From Implementation to Quality Control and Harmonization

Damoiseaux, Jan

doi:10.3389/fimmu.2021.656796

Cited by 8 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Double-positive AAV patients turned to be single-positive or negative for MPO-ANCA and PR3-ANCA during follow-up. It was reported that ANCA was considered to be a well-recognized diagnostic biomarker and the persistence of ANCA is related to the occurrence of relapse in the future [ 46 , 47 ]. However, it was controversial to use ANCA titers to predict disease activities and/or guide therapy [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical features and prognosis of ANCA-associated vasculitis patients who were double-seropositive for myeloperoxidase-ANCA and proteinase 3-ANCA

Gong,

Shen,

Meng

et al. 2024

Clin Exp Med

View full text Add to dashboard Cite

Anti-neutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) patients with dual positivity for proteinase 3-ANCA (PR3-ANCA) and myeloperoxidase-ANCA (MPO-ANCA) are uncommon. We aimed to investigate these idiopathic double-positive AAV patients’ clinical features, histological characteristics, and prognosis. We reviewed all the electronic medical records of patients diagnosed with AAV to obtain clinical data and renal histological information from January 2010 to December 2020 in a large center in China. Patients were assigned to the MPO-AAV group or PR3-AAV group or idiopathic double-positive AAV group by ANCA specificity. We explored features of idiopathic double-positive AAV. Of the 340 patients who fulfilled the study inclusion criteria, 159 (46.76%) were female, with a mean age of 58.41 years at the time of AAV diagnosis. Similar to MPO-AAV, idiopathic double-positive AAV patients were older and had more severe anemia, lower Birmingham Vasculitis Activity Score (BVAS) and C-reactive protein (CRP) levels, less ear, nose, and throat (ENT) involvement, higher initial serum creatinine and a lower estimated glomerular filtration rate (eGFR) when compared with PR3-AAV (P < 0.05). The proportion of normal glomeruli of idiopathic double-positive AAV was the lowest among the three groups (P < 0.05). The idiopathic double-positive AAV patients had the worst remission rate (58.8%) among the three groups (P < 0.05). The relapse rate of double-positive AAV (40.0%) was comparable with PR3-AAV (44.8%) (P > 0.05). Although there was a trend toward a higher relapse rate of idiopathic double-positive AAV (40.0%) compared with MPO-AAV (23.5%), this did not reach statistical significance (P > 0.05). The proportion of patients who progressed to ESRD was 47.1% and 44.4% in the idiopathic double-positive AAV group and MPO-AAV group respectively, without statistical significance. Long-term patient survival also varied among the three groups (P < 0.05). Idiopathic double-positive AAV is a rare clinical entity with hybrid features of MPO-AAV and PR3-AAV. MPO-AAV is the “dominant” phenotype in idiopathic double-positive AAV.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical features and prognosis of ANCA-associated vasculitis patients who were double-seropositive for myeloperoxidase-ANCA and proteinase 3-ANCA

Gong,

Shen,

Meng

et al. 2024

Clin Exp Med

View full text Add to dashboard Cite

show abstract

“…Unfortunately, the respective commercial assay is no longer available. As also established for ANCA-associated vasculitis [ 24 , 25 ], predicting disease relapses by rises in autoantibody levels should take into account disease subtype, definitions of relapse and rise in autoantibody level, frequency of autoantibody measurements, and type of assay used. As for diagnostic application, also for follow-up purposes sufficiently large studies comparing different immuno-assays in the same patient cohort are lacking.…”

Section: Anti-dsdna Antibodies In Relation To Disease Activitymentioning

confidence: 99%

Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosus

Damoiseaux

Beers

2023

Journal of Translational Autoimmunity

Self Cite

View full text Add to dashboard Cite

“…ANCAs have promising potential in the diagnostics process, assessing therapy efficacy and even predicting the disease onset and staging [98,99]. The prevailing evidence suggests focusing on ANCA-specific immunoassays development, due to their high sensitivity and specificity compared to results based on IIF.…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

The Role of Neutrophils in ANCA-Associated Vasculitis: The Pathogenic Role and Diagnostic Utility of Autoantibodies

Walulik,

Łysak,

Błaszkiewicz

et al. 2023

IJMS

View full text Add to dashboard Cite

Recent years have brought progress in understanding the role of the neutrophil, dispelling the dogma of homogeneous cells mainly involved in the prime defence against pathogens, shedding light on their pathogenic role in inflammatory diseases and on the importance of antineutrophil-cytoplasmic antibodies’ pathogenic role in ANCA-associated vasculitides vasculitis (AAV). Myeloperoxidase (MPO) and proteinase 3 (PR3) expressed in neutrophil granulocytes are the most common targets for ANCAs and contribute to the formation of MPO-ANCAs and PR3-ANCAs which, released to the bloodstream, become an excellent diagnostic tool for AAV. In this study, we focus on increasing the clinical and experimental evidence that supports the pathogenic role of ANCAs in AAV. Additionally, we discuss the diagnostic utility of ANCAs for disease activity and prognosis in AAV. Understanding the central role of ANCAs in AAV is crucial for advancing our knowledge of these complex disorders and developing targeted therapeutic strategies in the era of personalized medicine.

show abstract

ANCA Testing in Clinical Practice: From Implementation to Quality Control and Harmonization

Cited by 8 publications

References 45 publications

Clinical features and prognosis of ANCA-associated vasculitis patients who were double-seropositive for myeloperoxidase-ANCA and proteinase 3-ANCA

Clinical features and prognosis of ANCA-associated vasculitis patients who were double-seropositive for myeloperoxidase-ANCA and proteinase 3-ANCA

Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosus

The Role of Neutrophils in ANCA-Associated Vasculitis: The Pathogenic Role and Diagnostic Utility of Autoantibodies

Contact Info

Product

Resources

About