Ancestral and environmental patterns in the association between triglycerides and other cardiometabolic risk factors

Meeks, Karlijn; Bentley, Amy R.; Agyemang, Charles; Galenkamp, Henrike; Born, Bert-Jan H. van den; Hanssen, Nordin M.J.; Doumatey, Ayo P.; Adeyemo, Adebowale; Rotimi, Charles N.

doi:10.1016/j.ebiom.2023.104548

Cited by 7 publications

(2 citation statements)

References 41 publications

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“… 39 Additionally, the association between triglycerides and other cardiometabolic risk factors such as BMI, waist circumference, and hypertension appears to differ between people of European, West African, and East African origin. 40 Besides differences in high‐density lipoprotein cholesterol and triglycerides, significant differences exist in lipoprotein (a) concentrations, an independent risk factor for CVD with high heritability. 41 Individuals of African and, to a lesser extent, South Asian origin have generally much higher concentrations of lipoprotein (a) compared with European ancestry populations, while lipoprotein (a) levels among East Asian and Latin American origin are lower.…”

Section: Risk Factors For Cvd In Migrantsmentioning

confidence: 99%

International Migration and Cardiovascular Health: Unraveling the Disease Burden Among Migrants to North America and Europe

Agyemang,

van der Linden,

Chilunga

et al. 2024

JAHA

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Europe and North America are the 2 largest recipients of international migrants from low‐resource regions in the world. Here, large differences in cardiovascular disease (CVD) morbidity and death exist between migrants and the host populations. This review discusses the CVD burden and its most important contributors among the largest migrant groups in Europe and North America as well as the consequences of migration to high‐income countries on CVD diagnosis and therapy. The available evidence indicates that migrants in Europe and North America generally have a higher CVD risk compared with the host populations. Cardiometabolic, behavioral, and psychosocial factors are important contributors to their increased CVD risk. However, despite these common denominators, there are important ethnic differences in the propensity to develop CVD that relate to pre‐ and postmigration factors, such as socioeconomic status, cultural factors, lifestyle, psychosocial stress, access to health care and health care usage. Some of these pre‐ and postmigration environmental factors may interact with genetic (epigenetics) and microbial factors, which further influence their CVD risk. The limited number of prospective cohorts and clinical trials in migrant populations remains an important culprit for better understanding pathophysiological mechanism driving health differences and for developing ethnic‐specific CVD risk prediction and care. Only by improved understanding of the complex interaction among human biology, migration‐related factors, and sociocultural determinants of health influencing CVD risk will we be able to mitigate these differences and truly make inclusive personalized treatment possible.

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Section: Risk Factors For Cvd In Migrantsmentioning

confidence: 99%

International Migration and Cardiovascular Health: Unraveling the Disease Burden Among Migrants to North America and Europe

Agyemang,

van der Linden,

Chilunga

et al. 2024

JAHA

Self Cite

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“…Therefore, vitamin D levels and bone health in AA present a paradox. In addition, another unexplainable relationship seen in AA is the triglyceride (TG) paradox, an unusual phenomenon in which AA consistently express a normal TG status even when they have conditions known to be characterized by high TG levels, such as Type II diabetes, insulin resistance, and cardiovascular disease [10][11][12][13]. In this study, we compared levels of blood markers, including HbA1c, TG, and vitamin D, measured as serum 25-hydroxyvitamin D [25(OH)VD] uM/mL, [25(OH)VD]/TG, calcium, and BMD in AA and white subjects with Type II diabetes to see whether these relationships exist concurrently.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D/Bone Mineral Density and Triglyceride Paradoxes Seen in African Americans: A Cross-Sectional Study and Review of the Literature

Stevens,

Jain

2024

IJMS

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Vitamin D is known to have a positive effect on bone health. Despite the greater frequency of vitamin D deficiency in African Americans (AA), they have a higher bone mineral density (BMD) compared to whites, demonstrating a disconnect between BMD and vitamin D levels in AA. Another intriguing relationship seen in AA is the triglyceride (TG) paradox, an unusual phenomenon in which a normal TG status is observed even when patients house conditions known to be characterized by high TG levels, such as Type II diabetes. To the best of our knowledge, no study has examined whether these two paradoxical relationships exist simultaneously in AA subjects with Type II diabetes. In this study, we compared levels of blood markers, including HbA1c, TG, and vitamin D, measured as serum 25-hydroxyvitamin D [25(OH)VD] µM/mL, [25(OH)VD]/TG, calcium, and BMD in AA (n = 56) and white (n = 26) subjects with Type II diabetes to see whether these relationships exist concurrently. We found that AA subjects had significantly lower TG and [25(OH)VD] levels and a significantly higher BMD status compared to white subjects, even when the ages, BMI, duration of diabetes, HbA1c, and calcium levels were similar between the two groups. This demonstrates that these two paradoxical relationships exist simultaneously in Type II diabetic AA subjects. In addition to these findings, we discuss the current hypotheses in the literature that attempt to explain why these two intriguing relationships exist. This review also discusses four novel hypotheses, such as altered circulating levels and the potential role of estrogen and hydrogen sulfide on BMD and HMG-CoA reductase as a possible contributor to the TG paradox in AA subjects. This manuscript demonstrates that there are still many unanswered questions regarding these two paradoxical relationships and further research is needed to determine why they exist and how they can be implemented to improve healthcare.

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Triglyceride-glucose index predicts type 2 diabetes mellitus more effectively than oral glucose tolerance test-derived insulin sensitivity and secretion markers

Lee,

Bae,

Khang

et al. 2024

Diabetes Research and Clinical Practice

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Ancestral and environmental patterns in the association between triglycerides and other cardiometabolic risk factors

Cited by 7 publications

References 41 publications

International Migration and Cardiovascular Health: Unraveling the Disease Burden Among Migrants to North America and Europe

International Migration and Cardiovascular Health: Unraveling the Disease Burden Among Migrants to North America and Europe

Vitamin D/Bone Mineral Density and Triglyceride Paradoxes Seen in African Americans: A Cross-Sectional Study and Review of the Literature

Triglyceride-glucose index predicts type 2 diabetes mellitus more effectively than oral glucose tolerance test-derived insulin sensitivity and secretion markers

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