AncFlow: An Ancestral Sequence Reconstruction Approach for Determining Novel Protein Structural
Ryin Rouzbehani,
Scott T. Kelley
Abstract:The rapid growth of sequence data from high-throughput sequencing technologies has unveiled a vast number of previously unknown proteins, presenting a significant challenge in their functional characterization. Ancestral sequence reconstruction (ASR) has emerged as a powerful tool to elucidate the evolutionary history of protein families and identify sequence determinants of protein function. Here, we present AncFlow, an automated software pipeline that integrates phylogenetic analysis, subfamily identificatio… Show more
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