Ancillary Testing in the Management of Retinal Vein Occlusions

Browning, David J.

doi:10.1007/978-1-4614-3439-9_8

Cited by 4 publications

(4 citation statements)

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“…Possibly because they were below the detection threshold, some inner capillary blood vessels not observed on the preoperative OCTA images were seen postoperatively as shown in figure 1 . The FAZ border comprises a single-layered capillary arcade that lies within the ganglion cell layer, 29 and retinal ganglion cells (RGCs) depend on regional capillary networks to meet their high metabolic requirements. Moreover, deriving its oxygen supply from multiple retinal capillary plexuses, 30 31 the macula is one of the most metabolically active human tissues.…”

Section: Discussionmentioning

confidence: 99%

OCT angiography measured changes in the foveal avascular zone area after glaucoma surgery

et al. 2020

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Background/AimsTo evaluate quantitative changes in the foveal avascular zone (FAZ) area after glaucoma surgery using swept-source optical coherence tomography angiography (SS-OCTA).MethodsFifty-four consecutive patients with primary open-angle glaucoma (POAG) who met the inclusion criteria and underwent unilateral glaucoma surgery to reduce intraocular pressure (IOP) between April 2018 and July 2019.Eyes underwent IOP-lowering glaucoma surgery and their fellow (non-surgical) eyes were included. OCTA of the macula was performed in both eyes before glaucoma surgery and 3 months postoperatively. Two blinded examiners reviewed the image quality. Within- and between-group comparisons of the FAZ area and correlation of the FAZ area with age, IOP, central sensitivity and clinical variables.ResultsThe mean (±SD) age was 66.7±11.3 years. After surgery, the IOP and FAZ area significantly decreased from 22.1±9.5 mmHg to 10.3±3.5 mmHg and from 0.485±0.193 mm2 to 0.446±0.174 mm2, respectively (both p<0.001). Conversely, in the non-surgery group, the preoperative and postoperative mean FAZ areas (0.398±0.119 mm2 and 0.396±0.110 mm2, respectively) did not significantly differ (p=0.469). Change in the FAZ area significantly correlated with the preoperative FAZ area, preoperative foveal sensitivity and change in IOP (all p<0.05).ConclusionsThe FAZ area is decreased with IOP-lowering surgery in patients with POAG, and change in the FAZ area was significantly correlated with both preoperative foveal sensitivity and change in IOP.

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Section: Discussionmentioning

confidence: 99%

OCT angiography measured changes in the foveal avascular zone area after glaucoma surgery

et al. 2020

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“…Comparing the proteome of 30 RVO patients and 16 controls, we could define 16 proteins that were significantly up- or downregulated in RVO. Thrombosis and thrombolysis are involved in RVO as well as inflammatory processes due to hypoxic induced cell death [ 30 ]. This could be confirmed in our study as inflammatory response pathway, complement activation (classical pathway) as well as complement and coagulation cascades were identified as primary pathways of the 16 significant up- or downregulated proteins in VH of RVO patients compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Proteomic Analysis of Vitreous Humor in Retinal Vein Occlusion

et al. 2016

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PurposeTo analyze the protein profile of human vitreous of untreated patients with retinal vein occlusion (RVO).MethodsSixty-eight vitreous humor (VH) samples (44 from patients with treatment naïve RVO, 24 controls with idiopathic floaters) were analyzed in this clinical-experimental study using capillary electrophoresis coupled to mass spectrometer and tandem mass spectrometry. To define potential candidate protein markers of RVO, proteomic analysis was performed on RVO patients (n = 30) and compared with controls (n = 16). To determine validity of potential biomarker candidates in RVO, receiver operating characteristic (ROC) was performed by using proteome data of independent RVO (n = 14) and control samples (n = 8).ResultsNinety-four different proteins (736 tryptic peptides) could be identified. Sixteen proteins were found to be significant when comparing RVO and control samples (P = 1.43E-05 to 4.48E-02). Five proteins (Clusterin, Complement C3, Ig lambda-like polypeptide 5 (IGLL5), Opticin and Vitronectin), remained significant after using correction for multiple testing. These five proteins were also detected significant when comparing subgroups of RVO (central RVO, hemi-central RVO, branch RVO) to controls. Using independent samples ROC-Area under the curve was determined proving the validity of the results: Clusterin 0.884, Complement C3 0.955, IGLL5 1.000, Opticin 0.741, Vitronectin 0.786. In addition, validation through ELISA measurements was performed.ConclusionThe results of the study reveal that the proteomic composition of VH differed significantly between the patients with RVO and the controls. The proteins identified may serve as potential biomarkers for pathogenesis induced by RVO.

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“…We have described other SD-OCT associations with ischemia in acute CRVO, including the loss of definition of the boundaries between the inner retinal lamina and increased reflectivity of the inner retina 6. In this study, we addressed the question whether these signs have value in predicting visual outcome and development of ASNV in eyes with acute CRVO.…”

Section: Introductionmentioning

confidence: 96%

Assessment of ischemia in acute central retinal vein occlusion from inner retinal reflectivity on spectral domain optical coherence tomography

Browning

Punjabi

Lee

2016

OPTH

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PurposeTo determine the relationship between different spectral domain optical coherence tomography (SD-OCT) signs of retinal ischemia in acute central retinal vein occlusion (CRVO) and whether they predict anterior segment neovascularization (ASNV).DesignRetrospective, observational study.SubjectsThirty-nine consecutive patients with acute CRVO and 12 months of follow-up.MethodsWe graded baseline SD-OCTs for increased reflectivity of the inner retina, loss of definition of inner retinal layers, presence of a prominent middle-limiting membrane (p-MLM) sign, and presence of paracentral acute middle maculopathy (PAMM). Graders were masked with respect to all clinical information.ResultsThe intraclass correlation coefficients (ICCs) of grading–regrading by graders 1 and 2 were 0.8104, 95% confidence interval (CI) (0.6686, 0.8956), and 0.7986, 95% CI (0.6475, 0.8892), respectively. The intragrader coefficients of repeatability (COR) for graders 1 and 2 were 0.94 and 0.92, respectively. The ICC of graders 1 compared with 2 was 0.8039, 95% CI (0.6544, 0.8916). The intergrader COR was 0.80. SD-OCT grades of baseline ischemia were not associated with baseline visual acuity (VA), central subfield mean thickness (CSMT), or relative afferent pupillary defect; 12-month VA, CSMT, change in VA, change in CSMT, number of antivascular endothelial growth factor injections or corticosteroid injections, or proportion of eyes developing ASNV. SD-OCT grades of ischemia did not correlate with the proportion of eyes having the p-MLM sign or PAMM. PAMM and p-MLM are milder signs of ischemia than increased reflectivity of the inner retinal layers. Eyes with PAMM can evolve, losing PAMM and gaining the p-MLM sign.ConclusionGrading of ischemia from SD-OCT in acute CRVO was repeatable within graders and reproducible across graders for the graders in this study. SD-OCT signs of ischemia are not correlated with each other and do not reliably predict subsequent ASNV. Close monitoring of eyes with acute CRVO continues to be the safest method to avoid missing ASNV and neovascular glaucoma.

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Ancillary Testing in the Management of Retinal Vein Occlusions

Cited by 4 publications

References 100 publications

OCT angiography measured changes in the foveal avascular zone area after glaucoma surgery

OCT angiography measured changes in the foveal avascular zone area after glaucoma surgery

Proteomic Analysis of Vitreous Humor in Retinal Vein Occlusion

Assessment of ischemia in acute central retinal vein occlusion from inner retinal reflectivity on spectral domain optical coherence tomography

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