(+)- and (−)-trichodermatrione A: a pair of enantiomers with a cyclobutane-containing skeleton from the endophytic fungus Trichoderma sp. EFT2

Yan, Wei; Ji, Wenxia; Ping, Chuan; Zhang, Tianyi; Yu, Li; Wang, Biao; Chen, Tianyu; He, Bo; Ye, Yonghao

doi:10.1016/j.phytochem.2022.113087

Cited by 7 publications

(6 citation statements)

References 27 publications

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“…The in vitro bactericidal activities against eight bacteria (see Table S1) were performed in sterile 96-well microplates using the broth dilution method modified from previous research. , Twofold serial dilutions of the target compound dissolved in DMSO were prepared in sterile nutrient broth for a testing concentration range of 0.25–128 μg/mL. All wells of the 96-well microplate were filled with 100 μL of the dilution and inoculated with 100 μL of bacterial suspension (1 × 10 6 CFU/mL).…”

Section: Materials and Methodsmentioning

confidence: 99%

Discovery of Tropolone Stipitaldehyde as a Potential Agent for Controlling Phytophthora Blight and Its Action Mechanism Research

Wang

Chen

et al. 2022

J. Agric. Food Chem.

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The fermentation of endophytic Nigrospora chinensis GGY-3 resulted in the isolation of tropolone stipitaldehyde (1), which exhibited broad-spectrum inhibition activity against fungi and bacteria, especially against Phytophthora capsici, with an EC50 value of 0.83 μg/mL and Xanthomonas oryzae pv. oryzicola, with a minimum inhibitory concentration value of 4.0 μg/mL. The in vitro and in vivo assays demonstrated that 1 had a significant protective effect on P. capsici. Furthermore, 1 inhibited the spore germination of P. capsici and damaged the plasma membrane structure. As observed by SEM and TEM, after exposure to 1, mycelia exhibited swelling, shrunken, branch-increasing phenomena, cell wall and membrane damage, and disordered content. Transcriptome analysis revealed that 1 might affect starch and sucrose metabolism and fatty acid biosynthesis by suppressing the expression of genes relevant to cell wall synthetases and cell membrane-associated genes. These findings indicate that 1 may be a potential agrochemical fungicide for controlling phytophthora blight.

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Section: Materials and Methodsmentioning

confidence: 99%

Discovery of Tropolone Stipitaldehyde as a Potential Agent for Controlling Phytophthora Blight and Its Action Mechanism Research

Wang

Chen

et al. 2022

J. Agric. Food Chem.

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“…In the last five years, only three acorane sesquiterpenes have been reported. The first one, 8acoren-3,11-diol (133), was produced by the marine algicolous fungus T. harzianum X-5. 51 Compound 133 exhibited potent antimicroalgal activities against C. marina, with IC 50 values of 2.8 μg/mL.…”

Section: Cycloneranementioning

confidence: 99%

“…A pair of enantiomers, (±)-trichodermatrione A ( 367 and 368 ), containing a tricyclic 6/4/6 core and cyclobutene skeleton, were produced by Trichoderma sp. EFT2, derived from the stems of Euonymus fortune . They displayed antibacterial activities toward phytopathogenic bacteria (Xanthomonas oryzae pv oryzae (Xoo) and X.…”

Section: Secondary Metabolitesmentioning

confidence: 99%

Structures and Biological Activities of Secondary Metabolites from the Trichoderma genus (Covering 2018–2022)

Guo,

Shi,

Wang

et al. 2023

J. Agric. Food Chem.

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Trichoderma, a genus with more than 400 species, has a long history of use as an industrial bioreactor, biofertilizer, and biocontrol agent. It is considered a significant source of secondary metabolites (SMs) that possess unique structural features and a wide range of bioactivities. In recent years, numerous secondary metabolites of Trichoderma, including terpenoids, polyketides, peptides, alkaloids, and steroids, have been identified. Most of these SMs displayed antimicrobial, cytotoxic, and antifungal effects. This review focuses on the structural diversity, biological activities, and structure–activity relationships (SARs) of the SMs isolated from Trichoderma covered from 2018 to 2022. This study provides insights into the exploration and utilization of bioactive compounds from Trichoderma species in the agriculture or pharmaceutical industry.

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“…Trichoderma sp. have been reported to produce diverse secondary metabolites including alkaloids, − polyketones, − steroids, and terpenoids . Our subsequent chemical investigation on the EtOAc extract of the fermentation broth of T. asperellum G10 led to the identification of eight new phenethoxy derivatives, trichoasperellins A–H ( 1 – 8 ).…”

mentioning

confidence: 99%

Phenethoxy Derivatives with Anti-inflammatory Activities from the Betelnut Endophytic Trichoderma asperellum G10

et al. 2022

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Eight new phenethoxy derivatives, trichoasperellins A–H (1–8), were isolated from the endophytic fungus Trichoderma asperellum G10 isolated from the medicinal plant Areca catechu L. The structures of these compounds were elucidated from spectroscopic data, J-based configurational analysis, and Mosher’s methods. Compounds 1–4 and 6–8 bear one or two multioxidized C7 moieties with the same carbon skeleton. The carbon skeletons of compounds 6–8 are new, all containing three moieties connected via two acetal carbons similar to those of disaccharide glycosides. Compound 4 inhibited nitric oxide production with an IC50 value of 48.3 μM, comparable to that of the positive control indomethacin (IC50, 42.3 μM).

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(+)- and (−)-trichodermatrione A: a pair of enantiomers with a cyclobutane-containing skeleton from the endophytic fungus Trichoderma sp. EFT2

Cited by 7 publications

References 27 publications

Discovery of Tropolone Stipitaldehyde as a Potential Agent for Controlling Phytophthora Blight and Its Action Mechanism Research

Discovery of Tropolone Stipitaldehyde as a Potential Agent for Controlling Phytophthora Blight and Its Action Mechanism Research

Structures and Biological Activities of Secondary Metabolites from the Trichoderma genus (Covering 2018–2022)

Phenethoxy Derivatives with Anti-inflammatory Activities from the Betelnut Endophytic Trichoderma asperellum G10

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