Androgen receptor (AR)-CAG trinucleotide repeat length and idiopathic male infertility: a case-control trial and a meta-analysis

Mobasseri, Narges; Babaei, Faezeh; Karimian, Mohammad; Nikzad, Hossein

doi:10.17179/excli2018-1744

Cited by 11 publications

(1 citation statement)

References 66 publications

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“…In this study, we found a significant association between the AR CAG repeat length polymorphism and idiopathic infertility in Turkish men. This finding is supported by studies reporting a significant association between male infertility and CAG repeat expansion (Ashraf et al, 2020;Borjian Boroujeni et al, 2018;Giagulli et al, 2014;Mobasseri et al, 2018). We observed that idiopathic infertile men displayed longer CAG repeats than the fertile controls.…”

Section: Discussionsupporting

confidence: 88%

Polymorphisms of androgens‐related genes and idiopathic male infertility in Turkish men

et al. 2021

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Androgens, testosterone and dihydrotestosterone (DHT) are endocrine regulators of spermatogenesis and act via androgen receptor (AR). The aim of this study was to investigate the association(s) of AR (CAG repeat length), SRD5A2 (rs523349, V89L) and TNFα (rs1800629, -308G/A) polymorphisms with idiopathic male infertility in Turkish men. This case-control study consisted of 312 men with idiopathic infertility and 113 fertile men. Polyacrylamide gel electrophoresis (PAGE) or PCR-restriction fragment length polymorphism methods were used for genotyping. The mean AR CAG repeat length was significantly longer in infertile men than in fertile men (p = 0.015).However, there was no significant association between the SRD5A2 genotypes (VV, VL and LL) and the risk of infertility (p = 0.516). The genotype frequency and allele distribution of TNFα -308G/A polymorphism (GG, GA, AA genotypes and G, A alleles) were not associated with male infertility (p = 0.779 and p = 0.743 respectively).AR CAG repeat expansion might be one of the risk factors for idiopathic male infertility in Turkish men. Further studies investigating the association of male infertility with AR CAG, V89L and -308G/A polymorphisms are warranted to understand the possible associations among them.

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Section: Discussionsupporting

confidence: 88%

Polymorphisms of androgens‐related genes and idiopathic male infertility in Turkish men

et al. 2021

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Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management

Barati

Nikzad

Karimian

2019

Cell. Mol. Life Sci.

355

195

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Molecular mechanisms involved in anosmia induced by SARS-CoV-2, with a focus on the transmembrane serine protease TMPRSS2

2022

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Since 2020, SARS-CoV-2 has caused a pandemic virus that has posed many challenges worldwide. Infection with this virus can result in a number of symptoms, one of which is anosmia. Olfactory dysfunction can be a temporary or long-term viral complication caused by a disorder of the olfactory neuroepithelium. Processes such as inflammation, apoptosis, and neuronal damage are involved in the development of SARS-CoV-2-induced anosmia. One of the receptors that play a key role in the entry of SARS-CoV-2 into the host cell is the transmembrane serine protease TMPRSS2, which facilitates this process by cleaving the viral S protein. The gene encoding TMPRSS2 is located on chromosome 21. It contains 15 exons and has many genetic variations, some of which increase the risk of disease. Delta strains have been shown to be more dependent on TMPRSS2 for cell entry than Omicron strains. Blockade of this receptor by serine protease inhibitors such as camostat and nafamostat can be helpful for treating SARS-CoV-2 symptoms, including anosmia. Proper understanding of the different functional aspects of this serine protease can help to overcome the therapeutic challenges of SARS-CoV-2 symptoms, including anosmia. In this review, we describe the cellular and molecular events involved in anosmia induced by SARS-CoV-2 with a focus on the function of the TMPRSS2 receptor.

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Androgen receptor (AR)-CAG trinucleotide repeat length and idiopathic male infertility: a case-control trial and a meta-analysis

Cited by 11 publications

References 66 publications

Polymorphisms of androgens‐related genes and idiopathic male infertility in Turkish men

Polymorphisms of androgens‐related genes and idiopathic male infertility in Turkish men

Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management

Molecular mechanisms involved in anosmia induced by SARS-CoV-2, with a focus on the transmembrane serine protease TMPRSS2

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