Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population

Biolchi, Vanderlei; Neto, Brasil Silva; Koff, Walter José; Brum, Ilma Simoni

doi:10.1590/s1677-55382012000300010

Cited by 9 publications

(6 citation statements)

References 31 publications

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“…There were several association studies in CAG repeats of AR gene and BPH risk. In Brazilian study, there was no evidence for an association between AR CAG repeat length in BPH risk in a population-based sample (Biolchi et al, 2012). However, Renko et al (2008) reported that there was an association between short AR gene CAG repeat length and a small prostate volume, which confirms a previous finding in the Finnish population.…”

Section: Discussionmentioning

confidence: 90%

Combined effect of polymorphisms in type III 5-α reductase and androgen receptor gene with the risk of benign prostatic hyperplasia in Korea

Lee

et al. 2016

J Exerc Rehabil

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We evaluated whether type III 5-alpha reductase (SRD5A3; steroid reductase 5-alpha 3) polymorphism was associated with susceptibility of benign prostate hyperplasia (BPH) and the combined effects in BPH risk between the type of short tandem repeat (STR) in SRD5A3 and the length of trinucleotide (CAG) repeats in androgen receptor (AR) gene. We compared the length of AC repeats in STR region of SRD5A3 gene and a CAG repeat in AR in 188 BPH patients who underwent transurethral resection of prostate (TURP) and 98 controls by polymerase chain reaction-based methods. We defined short type was less than 21 copies of AC repeats. The odds ratio for BPH between the men with at least one of short type and with both large types of STR in SRD5A3 gene was 3.10 (95% confidence interval [CI], 1.87–5.16; P=0.000). And BPH was 2.35 times more likely to occur in with less than 23 copies of CAG repeats than men equal or greater than 23 copies in AR gene (95% CI, 1.18–2.36; P=0.016). The men with the large type of STR and ≥23 copies of CAG repeats have 5.3 times BPH risk compared to the reference group with the at least one of the short type of STR and <23 copies (P<0.000). In conclusion, these results suggest that shorter AC repeats of SRD5A3 gene and shorter CAG repeats of AR gene were associated with an increased risk for BPH. However, the interaction between above two factors was not affected in risk of BPH.

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Section: Discussionmentioning

confidence: 90%

Combined effect of polymorphisms in type III 5-α reductase and androgen receptor gene with the risk of benign prostatic hyperplasia in Korea

Lee

et al. 2016

J Exerc Rehabil

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“…There are a considerable studies have been conducted to investigate the association between CAG and or GGC repeats located in Xq11.2, and incidence of BPH and PrCa (Alptekin et al, 2012;Biolchi et al, 2012;Cunningham et al, 2007;Giovannucci et al, 1997;Gsur et al, 2002;Gu et al, 2012;Gudmundsson et al, 2008;Lee et al, 2016;Neto et al, 2008;D. Riley and Krieger, 2001).…”

Section: Identification Of Potential Genes For Benign Prostatic Hyperplasia and Prostate Cancer Susceptibility In Four X-chromosome Regiomentioning

confidence: 99%

Identification of Potential Genes for Benign Prostatic Hyperplasia and Prostate Cancer Susceptibility in Four X-chromosome Regions with High Frequency of Microvariant Alleles

Albujja

Messaudi

Ramachandran

et al. 2020

Asian Pac J Cancer Prev

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Background: The X-chromosome has been suggested to play a role in prostate cancer (PrCa) since epidemiological studies have provided evidence for an X-linked mode of inheritance for PrCa based on the higher relative risk among men who report an affected brother(s) as compared to those reporting an affected father. The aim of this study was to examine the potential association between the forensic STR markers located at four regions Xp22.31, Xq11.2-12, Xq26.2, and Xq28 and the risk of BPH and PrCa to confirm the impact of ChrX in the PrCa incidence. This may be helpful in the incorporation of STRs genetic variation in the early detection of men population at risk of developing PrCa. Methods: DNA samples from 92 patients and 156 healthy controls collected from two medical centers in Riyadh, Saudi Arabia were analyzed for four regions located at X-chromosome using the Investigator ® Argus X-12 QS Kit. Results: The results demonstrated that microvariant alleles of (DXS7132, DXS10146, HPRTB, DXS10134, and DXS10135) are overrepresented in the BPH group (p < 0.00001). Allele 28 of DXS10135 and allele 15 of DXS7423 could have a protective effect, OR 0.229 (95%CI, 0.066-0.79); and OR 0.439 (95%CI, 0.208-0.925). On the other hand, patients carrying allele 23 of DXS10079 and allele 26 of DXS10148 presented an increased risk to PrCa OR 4.714 (95%CI,. Conclusion: The results are in concordance with the involvement of the X chromosome in PrCa and BPH development. STR allele studies may add further information from the definition of a genetic profile of PrCa resistance or susceptibility. As TBL1, AR, LDOC1, and RPL10 genes are located at regions Xp22.31, Xq11.2-12, Xq26.2, and Xq28, respectively, these genes could play an essential role in PrCa or BPH.

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“…Prostat kanserine benzer olarak farklı popülasyonlarda farklı sonuçlar elde edildi. Japonya ve ABD'de yapılan çalışmalarda AR genin kısa CAG tekrar uzunluğu ile prostat büyüklüğü arasında anlamlı ilişki tespit edilirken (13,14), Hindistan ve Brezilya'da yapılan çalışmalarda ise bu anlamlı ilişki tespit edilemedi (15,16).…”

Section: Androjen Reseptör Gen Polimorfizmiunclassified

Genetic Basis of Benign Prostatic Hyperplasia Etiology

Özden¹,

Gökkaya²

2015

uob

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Benign prostat hiperplazisi (BPH), orta ve ileri yaşlarda ki erkeklerde görülen en sık hastalıklardan biridir. Bu nedenle BPH'nin etiyopatogenezi ve ilişkili risk faktörlerinin ortaya çıkarılması tanı ve tedavi için önemlidir. Son yıllarda yapılan çalışmalarda etiyolojik faktörler olarak heredite ve genetik faktörlerin önemi vurgulanmaktadır. Herediter BPH'nin tespiti hastalık patogenezinde sorumlu bir genin varlığını düşündürmüştür. Bu amaçla birçok çalışmada BPH ile androjen reseptör gen, vitamin D reseptör gen, α1a-adrenoreseptör gen polimorfizmi ve androjen metabolizmasındaki genlerin polimorfizmleri arasındaki ilişki araştırılmıştır ve çelişkili sonuçlar elde edilmiştir. Bilgilerin netleşmesi için farklı popülasyonlarda daha fazla sayıda çalışmalara ihtiyaç vardır. Anahtar Kelimeler: Benign prostat hiperplazisi, heredite, polimorfizm, patogenez Benign prostate hyperplasia (BPH) is one of the most common diseases in men of middle and advanced ages. For this reason, the discovery of etiopathogenesis and associated risk factors is important for diagnosis and treatment of BPH. Recent studies have emphasized the importance of hereditary and genetic factors as etiological factors. The detection of hereditary BPH suggested an existence of a gene in the pathogenesis of the disease. For this purpose, the relationship between BPH and the polymorphisms of androgen receptor gene, vitamin D receptor gene, α1a-adrenoreceptor gene and the polymorphisms of the genes which are responsible in androgen metabolism has been investigated by many studies and contradictory results have been obtained. More studies are needed in different populations to clarify the information. Ge liş Ta ri hi/Re cei ved: 02.09.2015 Ka bul Ta ri hi/Ac cep ted: 03.09.2015 © Üroonkoloji Bülteni, Ga le nos Ya yı ne vi ta ra fın dan ba sıl mış tır./ © Bulletin of Urooncology, Pub lis hed by Ga le nos Pub lis hing.

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Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population

Abstract: ARTIcLe InfO ___________________________________________ _

Cited by 9 publications

References 31 publications

Combined effect of polymorphisms in type III 5-α reductase and androgen receptor gene with the risk of benign prostatic hyperplasia in Korea

Combined effect of polymorphisms in type III 5-α reductase and androgen receptor gene with the risk of benign prostatic hyperplasia in Korea

Identification of Potential Genes for Benign Prostatic Hyperplasia and Prostate Cancer Susceptibility in Four X-chromosome Regions with High Frequency of Microvariant Alleles

Genetic Basis of Benign Prostatic Hyperplasia Etiology

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Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population

Abstract: ARTIcLe InfO _______________________________________________________________ _____________________

Cited by 9 publications

References 31 publications

Combined effect of polymorphisms in type III 5-α reductase and androgen receptor gene with the risk of benign prostatic hyperplasia in Korea

Combined effect of polymorphisms in type III 5-α reductase and androgen receptor gene with the risk of benign prostatic hyperplasia in Korea

Identification of Potential Genes for Benign Prostatic Hyperplasia and Prostate Cancer Susceptibility in Four X-chromosome Regions with High Frequency of Microvariant Alleles

Genetic Basis of Benign Prostatic Hyperplasia Etiology

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Abstract: ARTIcLe InfO ___________________________________________ _