Androgen receptor expression in normal, hyperplastic and neoplastic hepatoid glands in the dog

Pisani, G; Millanta, Francesca; Lorenzi, Davide De; Vannozzi, Iacopo; Poli, Alessandro

doi:10.1016/j.rvsc.2005.11.001

Cited by 42 publications

(43 citation statements)

References 13 publications

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“…A alta frequência de machos com neoplasma de glân-dula perianal pode ser explicada pelo fato das glândulas perianais serem andrógeno-dependentes. Pisani et al (2006) comprovaram um maior número de receptores androgênicos em glândulas perianais hiperplásicas e encontraram os receptores em adenoma, epitelioma e carcinoma perianal. Esse achado reforça a importância da orquiectomia como parte do tratamento em machos.…”

Section: Discussionunclassified

Prevalência de neoplasmas cutâneos em cães da região metropolitana de Porto Alegre, RS: 1.017 casos (2002-2007)

Meirelles

Oliveira

Rodrigues³

et al. 2010

Pesq. Vet. Bras.

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Pesq. Vet. Bras. 30(11):968-973, novembro 2010 RESUMO.-O objetivo deste trabalho foi realizar um estudo retrospectivo sobre neoplasias cutâneas diagnosticadas em cães. A avaliação foi realizada pela análise dos arquivos diagnósticos do Setor de Patologia Veterinária (SPV) da Universidade Federal do Rio Grande do Sul (UFRGS), Brasil, considerando-se um intervalo de seis anos (2002 a 2007). Neste intervalo, um total de 1.869 (37,3%) amostras de pele canina foram obtidas de 5.016 amostras variadas de tecidos de cães encaminhadas ao SPV. Dentre as amostras cutâneas, 1.002 pertenciam a cães diagnosticados com um tipo de neoplasia cutânea e 15 animais apresentaram mais de uma neoplasia de pele, totalizando 1.017 (20,3%) amostras. Os resultados revelaram que 50,5% (514/1017) das neoplasias cutâneas apresentaram origem mesenquimal, 45,1% (459/1017) para epitelial e 3,9% (40/1017) para melanocítica. Mastocitoma foi o tipo neoplásico cutâneo mais frequente, diagnosticado em 228 casos (22,4%), seguido por carcinoma de célu-las escamosas (7,5%), lipoma (7,3%), adenoma de glân-dula perianal (7,1%) e tricoblastoma (5,8%). Cocker Spaniel, Boxer, Poodle e Pastor Alemão foram as raças mais representadas em diversos neoplasmas. Os dados obtidos, comparados aos estudos prévios, ressaltam as variáveis raças, idade e sexo, relacionadas a alguns tumores cutâ- Prevalência de neoplasmas cutâneos em cães daRegião Metropolitana de Porto Alegre, RS: 1.017 casos

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Section: Discussionunclassified

Prevalência de neoplasmas cutâneos em cães da região metropolitana de Porto Alegre, RS: 1.017 casos (2002-2007)

Meirelles

Oliveira

Rodrigues³

et al. 2010

Pesq. Vet. Bras.

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“…Perianal tumors arise from the perianal glands (circumanal or hepatoid glands) and are very common in older, intact male dogs, but rare in female dogs (Holt, 1985;Berrocal et al, 1989;Shelley, 2002;Pisani et al, 2006). Perianal tumors may occur as solitary or multiple lesions (Shelley, 2002).…”

Section: Introductionmentioning

confidence: 99%

Electrochemotherapy is highly effective for the treatment of canine perianal hepatoid adenoma and epithelioma

Tozon¹,

Kodre²,

Juntes³

et al. 2010

Acta vet. (Beogr.)

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Perianal tumors are common in older male dogs. The usefulness of electrochemotherapy in veterinary oncology has already been demonstrated by clinical studies on different malignancies in companion animals. In a prospective non-randomized study, we evaluated the effectiveness of electrochemotherapy in 5 male dogs with 26 perianal adenocarcinomas and 16 male dogs with 40 benign tumors. After premedication and under general anesthesia, the dogs were treated with intratumoral administration of a chemotherapeutic drug (cisplatin or bleomycin) and exposure of tumors to electric pulses, delivered by two different electroporation protocols (Protocol 1 or Protocol 2). At the end of the observation time (median 14 months), an objective response (OR) was obtained in 62/66 tumors (94%) with 87.9% complete responses (CR). No statistically significant difference in OR rate was observed based on histological type (p = 0.110), previous castration (p = 0.088), chemotherapeutic drug used (p = 0.657), and electroporation protocol (p = 0.337). Tumor size at the beginning of the treatment was the only parameter that influenced the treatment outcome (p = 0.04). No major local or general side-effects were noted. We can conclude that electrochemotherapy is an easy, highly effective, safe and cost-effective local approach for the treatment of primary perianal tumors of dogs, especially hepatoid adenoma and epithelioma

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“…Tumours of these glands occur primarily in intact males and often fully or partially regress following castration; furthermore, one study showed a correlation between increased androgen receptor (AR) expression and circumanal gland hyperplasia, with a higher percentage of positivity found in reserve cells. An additional increase in the percent of positive cells was observed in circumanal gland epitheliomas (Pisani et al, 2006).…”

Section: Discussionmentioning

confidence: 83%

Histopathological Findings and Proliferative Activity of Canine Sebaceous Gland Tumours with a Predominant Reserve Cell Population

Sabattini

Bassi

Bettini

2015

Journal of Comparative Pathology

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Androgen receptor expression in normal, hyperplastic and neoplastic hepatoid glands in the dog

Cited by 42 publications

References 13 publications

Prevalência de neoplasmas cutâneos em cães da região metropolitana de Porto Alegre, RS: 1.017 casos (2002-2007)

Prevalência de neoplasmas cutâneos em cães da região metropolitana de Porto Alegre, RS: 1.017 casos (2002-2007)

Electrochemotherapy is highly effective for the treatment of canine perianal hepatoid adenoma and epithelioma

Histopathological Findings and Proliferative Activity of Canine Sebaceous Gland Tumours with a Predominant Reserve Cell Population

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