Androgen receptor gene CAG repeat polymorphism and ovarian cancer risk: A meta-analysis

Deng, Yang; Wang, Jue; Du, Yan

doi:10.5582/bst.2016.01229

Cited by 6 publications

(5 citation statements)

References 41 publications

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“…Men with a mutation in AR(CAG)n (where n refers to the number of CAG repeats, n > 38) manifest Kennedy’s disease or spinobulbar muscular atrophy ( La Spada et al., 1991 , 1992 ), while low n alleles have been associated with risk for prostate cancer and benign prostatic hyperplasia ( Giovannucci et al., 1999 ; Kumar et al., 2011 ; Qin et al., 2016 ). In women, AR(CAG)n has been associated with testosterone levels ( Westberg et al., 2001 ), bone mineral density ( Yamada et al., 2005 ) and obesity ( Gustafson et al., 2003 ) as well as cancers of the breast and ovaries ( Deng et al., 2017 ; Hao et al., 2010 ).…”

Section: Introductionmentioning

confidence: 99%

The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure

et al. 2020

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Section: Introductionmentioning

confidence: 99%

The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure

et al. 2020

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“…Previous studies regarding the association between AR gene CAG repeat length and ovarian cancer risk reported inconsistent results. 36 Overall, there was no association between the AR CAG repeat polymorphism and ovarian cancer risk. Meanwhile, short CAG repeat polymorphism was associated with increased ovarian cancer risk in African Americans and Chinese under the dominant model.…”

Section: Discussionmentioning

confidence: 93%

“…Meanwhile, short CAG repeat polymorphism was associated with increased ovarian cancer risk in African Americans and Chinese under the dominant model. 36 However, there were no studies to investigate an association of AR single nucleotide polymorphisms with lung cancer in previous studies. Further well-designed epidemiological and functional studies are needed to elucidate the role of AR in lung carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Radon Exposure-induced Genetic Variations in Lung Cancers among Never Smokers

et al. 2018

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BackgroundLung cancer in never smokers (LCINS) differs etiologically and clinically from lung cancer attributed to smoking. After smoking, radon exposure is the second leading cause and the primary risk factor of lung cancer among never smokers. Exposure to radon can lead to genetic and epigenetic alterations in tumor genomes affecting genes and pathways involved in lung cancer development. The present study sought to explore genetic alterations associated with LCINS exposed to radon gas indoors.MethodsGenetic associations were assessed via a case-control study of LCINS (39 cases and 30 controls) using next generation sequencing. Associations between genetic mutations and high exposure to radon were investigated by OncoPrint and heatmap graphs. Bioinformatic analysis was conducted using various tools. According radon exposure levels, we divided subjects in two groups of cases and controls.ResultsWe found that ABL2 rs117218074, SMARCA4 rs2288845, PIK3R2 rs142933317, MAPK1 rs1803545, and androgen receptor (AR) rs66766400 were associated with LCINS exposed to high radon levels. Among these, Chromodomain helicase DNA-binding protein 4 (CHD4) rs74790047, TSC2 rs2121870, and AR rs66766408 were identified as common exonic mutations in both lung cancer patients and normal individuals exposed to high levels of radon indoor.ConclusionWe identified that CHD4 rs74790047, TSC2 rs2121870, and AR rs66766408 are found to be common exonic mutations in both lung cancer patients and normal individuals exposed to radon indoors. Further analysis is needed to determine whether these genes are completely responsible for LCINS exposed to residential radon.

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“…However, analysis of Ashkenazi Jewish patients [ 56 ] and Italian patients [ 57 ] found no association between AR repeat length and OVCA. Therefore, the association between the repeated polymorphism and the risk of OVCA varies among ethnicities [ 58 ].…”

Section: Molecular Biological Characteristics Of a And Armentioning

confidence: 99%

Molecular Regulation of Androgen Receptors in Major Female Reproductive System Cancers

Lian

et al. 2022

IJMS

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There are three main types of cancer in the female reproductive system, specifically ovarian cancer (OVCA), endometrial cancer (EC), and cervical cancer (CC). They are common malignant tumors in women worldwide, with high morbidity and mortality. In recent years, androgen receptors (ARs) have been found to be closely related to the occurrence, progression, prognosis, and drug resistance of these three types of tumors. This paper summarizes current views on the role of AR in female reproductive system cancer, the associations between female reproductive system cancers and AR expression and polymorphisms. AR regulates the downstream target genes transcriptional activity and the expression via interacting with coactivators/corepressors and upstream/downstream regulators and through the gene transcription mechanism of “classical A/AR signaling” or “non-classical AR signaling”, involving a large number of regulatory factors and signaling pathways. ARs take part in the processes of cancer cell proliferation, migration/invasion, cancer cell stemness, and chemotherapeutic drug resistance. These findings suggest that the AR and related regulators could target the treatment of female reproductive system cancer.

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Androgen receptor gene CAG repeat polymorphism and ovarian cancer risk: A meta-analysis

Cited by 6 publications

References 41 publications

The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure

The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure

Radon Exposure-induced Genetic Variations in Lung Cancers among Never Smokers

Molecular Regulation of Androgen Receptors in Major Female Reproductive System Cancers

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