Androgenetic alopecia and microinflammation

Androgenic alopecia and dutasteride in hair mesotherapy: A short review

“…DHT, which present 10 times more affinity to androgen receptors compared to testosterone, binds to these receptors in genetically predisposed hair follicles, impairing hair cycle. The landmark decrease of anagen phase occur, anticipating catagen phase in a complex process involving apoptosis as probably microinflammation [10,25]. The involvement of hair follicle microinflammation in AGA is being reported since the 1970s.…”

“…A diverse combination of genetical factors, endocrine abnormalities, circulating androgens, drugs, diet and microinflammation in hair follicles of each individual are related to this condition [8][9][10].…”

Addressing Androgenetic Alopecia-A Complex Disorder-with a Multilateral Treatment Strategy

“…12 Activated T-cells have been observed to infiltrate near the follicular infundibulum. 13 In fact the inflammation in hair follicles could result from multitude of internal and/or external factors such as due to microbial infection, use of harsh chemicals, oxidative stress, normal aging, smoking and excessive exposure to sunlight and pollutants. Each of these factors are capable of increasing levels of free radicals in hair follicles which is detrimental to overall follicle health.…”

Minoxidil: a final judgment or a hope?

“…Безусловно, генети-ческая чувствительность ВФ к андрогенам является основой развития андрогенетической алопеции, но это не объясняет некоторых моментов, связанных с развитием АГА, в частности, наличие умеренного неспецифического инфильтрата в перифолликуляр-ной зоне, состоящего, в основном, из иммуноком-петентных Т-лимфоцитов [31]. Причиной подобно-го воспаления в первую очередь могут быть бакте-рии, колонизирующие инфундибулярную зону фол-ликула, такие как Propionibacterium spp., Staphylococcus spp., Malassezia spp.…”