Andrographolide: Chemical modification and its effect on biological activities

Kumar, Gulshan; Singh, Davinder; Tali, Javeed Ahmad; Dheer, Divya; Shankar, Ravi

doi:10.1016/j.bioorg.2019.103511

Cited by 67 publications

(42 citation statements)

References 90 publications

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“…Other compounds have also been identified to exhibit antagonistic activity on FXR include andrographolide (representative bioactive constituent of Andrographis paniculata Nees ) [103] , tuberatolides (from the Korean marine tunicate Botryllus tuberatus ) [104] 3,5-disubstituted oxadiazole core [98] , DY268 [97] and so on.…”

Section: Ligand-binding Properties Of Fxrmentioning

confidence: 99%

Farnesoid X receptor (FXR): Structures and ligands

Jiang

Zhang

Xiao

et al. 2021

Computational and Structural Biotechnology Journal

137

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Section: Ligand-binding Properties Of Fxrmentioning

confidence: 99%

Farnesoid X receptor (FXR): Structures and ligands

Jiang

Zhang

Xiao

et al. 2021

Computational and Structural Biotechnology Journal

137

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“…Wild populations can be found throughout Southern India and Sri Lanka; cultivated populations are found in Northern India, Java, Malaysia, Indonesia, the West Indies, parts of the Americas, the Philippines, Hong Kong, Thailand, Brunei, Singapore and other regions of Asia. The main compound of the plant is andrographolide secondary metabolite, the highest content of which is concentrated in the stem, flowering tops and roots [ 114 ]. Antitumor, anti-inflammatory, antimicrobial, antioxidant, cytotoxic, hepatoprotective, immunostimulating and antiviral activities of this metabolite have been established [ 114 , 115 ].…”

Section: Resultsmentioning

confidence: 99%

“…The main compound of the plant is andrographolide secondary metabolite, the highest content of which is concentrated in the stem, flowering tops and roots [ 114 ]. Antitumor, anti-inflammatory, antimicrobial, antioxidant, cytotoxic, hepatoprotective, immunostimulating and antiviral activities of this metabolite have been established [ 114 , 115 ]. The ability of Andrographis paniculata to treat viral respiratory infections has been confirmed in ayurvedic and other non-traditional medical practices [ 116 , 117 ].…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants to Strengthen Immunity during a Pandemic

et al. 2020

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The development of new effective anti-coronavirus drugs and therapies is important, but it requires significant human, financial and, most importantly, time expenditures. The current pandemic is neither the first nor the last. Humanity has already accumulated considerable survival experience. We cannot do without prevention and epidemiological protection measures. This study reviews medicinal plants that grow in Northeast Asia and whose antioxidant, antiviral, anti-inflammatory and immunomodulatory characteristics are already known, also in the framework of the prevention and treatment of pneumonia of various etiologies. The need for a comprehensive approach to maintaining immunodefences, including functional foods and positive emotions, is emphasized. In the period of pandemics, it is important to research various areas that allow to us accumulate a critical mass of information and cope with the next global disease.

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“…It is has been known for a long time that synthetic modification of natural products impacts their biological profiles, and so the derivatization of these naturally occurring compounds is a time‐honored pursuit [128–129] . An interesting compound, 56 , was reported by Rasool et al.…”

Section: Pharmacological Profile Of Isoxazoline Derivativesmentioning

confidence: 99%

2‐Isoxazolines: A Synthetic and Medicinal Overview

Kumar

Shankar

2020

ChemMedChem

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Isoxazolines are nitrogen‐ and oxygen‐containing five‐membered heterocyclic scaffolds with extensive biological activities. This framework can be readily obtained in good to excellent yields through 1,3‐dipolar cycloaddition between nitrones with alkynes or allenes, aryl/alkyl halides, alkynes, and oxaziridines under mild conditions. This scaffold has been an emerging area of interest for many researchers given their wide range of bioactivities. Herein we review synthetic strategies toward isoxazolines and the role these efforts have had in enhancing the biological activity of natural products and synthetic compounds such as antitubercular agents, COX‐1 inhibitors, COX‐2 inhibitors (e. g., valdecoxib), nicotinic receptor modulators, and MIF inhibitors. With a focus on efforts from 2010 onward, this review provides in‐depth coverage of the design and biological evaluation of isoxazoline systems and their impact on various pathologies.

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Andrographolide: Chemical modification and its effect on biological activities

Cited by 67 publications

References 90 publications

Farnesoid X receptor (FXR): Structures and ligands

Farnesoid X receptor (FXR): Structures and ligands

Medicinal Plants to Strengthen Immunity during a Pandemic

2‐Isoxazolines: A Synthetic and Medicinal Overview

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