Andrographolide impairs alpha-naphthylisothiocyanate-induced cholestatic liver injury in vivo

Wang, Lei; Cao, Fei; Zhu, Lili; Liu, Peng; Shang, Yongpeng; Liu, Wenhui; Dong, Xin; Bao, Hanying; Gong, Peng; Wang, Zhongyu

doi:10.1007/s11418-018-01275-3

Cited by 27 publications

(15 citation statements)

References 37 publications

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“…A concentration of 1 µM (0.35 µg/mL) in plasma is obtained within 30 min after administration of 50 mg/kg and bioavailability is 1.19% [25]. Andrographolide was measured in plasma and various rat Several data have reported the antioxidant activities of andrographolide in various in vitro and in vivo model systems [22,23]. This review describes its pharmacokinetic parameters and examines the current status regarding the antioxidant effect of andrographolide.…”

Section: Andrographolide Bioavailabilitymentioning

confidence: 99%

“…Many studies have focused on the anti-viral [12][13][14], anti-thrombotic [15,16], hepatoprotective [17,18], anticancer [19,20], and anti-inflammatory properties [21] of andrographolide. Several data have reported the antioxidant activities of andrographolide in various in vitro and in vivo model systems [22,23]. This review describes its pharmacokinetic parameters and examines the current status regarding the antioxidant effect of andrographolide.…”

Section: Introductionmentioning

confidence: 99%

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Andrographolide, A Natural Antioxidant: An Update

et al. 2019

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Traditionally, Andrographis paniculata has been used as an herbal remedy for lung infection treatments. Its leaves contain a diterpenoid labdane called andrographolide responsible for a wide range of biological activities such as antioxidant, anti-inflammatory, and anti-cancer properties. This manuscript is a brief review of the antioxidant mechanisms and the regulation of the Nrf2 (nuclear factor (erythroid-derived 2)-like 2) signaling pathway by andrographolide.

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Section: Andrographolide Bioavailabilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Andrographolide, A Natural Antioxidant: An Update

et al. 2019

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“…Furthermore, decreased malondialdehyde and increased superoxide dismutase, GSH, and glutathione peroxidase were observed in andrographolide‐treated rats. The mechanism might involve simultaneously promoting SIRT1 and NRF2 as well as attenuating NF‐κB and cyclooxygenase‐2 targets (Wang et al, ).…”

Section: Other Compoundsmentioning

confidence: 99%

Natural products for the prevention and treatment of cholestasis: A review

Jiang

Zhang

et al. 2020

Phytotherapy Research

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Cholestasis is a common manifestation of decreased bile flow in various liver diseases. It results in fibrosis and even cirrhosis without proper treatment. It is believed that a wide range of factors, including transporter dysfunction, oxidative stress, inflammatory damage, and immune disruption, can cause cholestasis. In recent years, natural products have drawn much attention for specific multiple-target activities in diseases. Many attempts have been made to investigate the anticholestatic effects of natural products with advanced technology. This review summarizes recent studies on the biological activities and mechanisms of recognized compounds for cholestasis treatment. Natural products, including various flavonoids, phenols, acids, quinones, saponins, alkaloids, glycosides, and so on, function as comprehensive regulators via ameliorating oxidative stress, inflammation, and apoptosis, restoring bile acid balance with hepatic transporters, and adjusting immune disruption. Moreover, in this progress, nuclear factor erythroid 2-related factor 2, reactive oxygen species production, heme oxygenase-1, NF-κB, cholesterol 7 alpha-hydroxylase, and farnesoid X receptors are thought as main targets for the activity of natural products. Therefore, this review presents the detailed mechanisms that include multiple targets and diverse signalling pathways. Natural products are the valuable when seeking novel therapeutic agents to treat cholestatic liver diseases.

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“…Recent studies have demonstrated that accumulations of high cholesterol and cholesterol crystals in the livers increased cholesterol-induced 14-deoxy-11,12-didehydroandrographolide (deAND), neoandrographolide, 14-acetylandrographolide, and 14-deoxyandropholide [14]. Of these, AND is the most abundant terpenoid in A. paniculata and has been reported to have many biological functions, including liver-protective effects probably resulting from increases in antioxidant and anti-inflammatory activities [15][16][17][18]. deAND, the second-most abundant diterpenoid in A. paniculata, is present in a comparative concentration to AND in the leaves of the plant (~17.4 mg/g) [19].…”

Section: Introductionmentioning

confidence: 99%

“…Because AND has been demonstrated to have liver-protective effects [16][17][18][19], it is possible that deAND may be an effective agent on treating liver diseases. This study was the first to investigate the hepatoprotective effects of deAND in a HFHC diet-induced steatohepatitis and liver injury in mice.…”

Section: Introductionmentioning

confidence: 99%

A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet

et al. 2020

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14-Deoxy-11,12-didehydroandrographolide (deAND), a diterpenoid in Andrographis paniculata (Burm. f.) Nees, acts as a bioactive phytonutrient that can treat many diseases. To investigate the protective effects of deAND on reducing fatty liver disease, male mice were fed a high-fat and high-cholesterol (HFHC) diet without or with 0.05% and 0.1% deAND supplementation. Cholesterol accumulation, antioxidant, and anti-inflammatory activities in liver and liver injury were evaluated after deAND treatment. The results show that deAND treatment for seven weeks reduced plasma alanine aminotransferase activity and lowered hepatic cholesterol accumulation, tumor nuclear factor-α, and histological lesions. The 0.1% deAND treatment reduced HFHC diet-induced apoptosis by lowering the caspase 3/pro-caspase 3 ratio. After 11 weeks of deAND treatment, increased NOD-like receptor protein 3 (NLRP3), capase-1, and interleukin-1β protein levels in liver were suppressed by deAND treatment. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) mRNA expression, heme oxygenase-1 protein expression, and the activities of glutathione peroxidase and glutathione reductase were increased in mice fed the HFHC diet. However, those activities of antioxidant enzymes or proteins were also upregulated by 0.1% deAND treatment. Furthermore, deAND treatment tended to lower hepatic lipid peroxides. Finally, deAND treatment reversed the depletion of hepatic glutamate level induced by the HFHC diet. These results indicate that deAND may ameliorate HFHC diet-induced steatohepatitis and liver injury by increasing antioxidant and anti-inflammatory activities.

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Andrographolide impairs alpha-naphthylisothiocyanate-induced cholestatic liver injury in vivo

Cited by 27 publications

References 37 publications

Andrographolide, A Natural Antioxidant: An Update

Andrographolide, A Natural Antioxidant: An Update

Natural products for the prevention and treatment of cholestasis: A review

A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet

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