2011
DOI: 10.1177/1947601911409744
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Andrographolide Targets Androgen Receptor Pathway in Castration-Resistant Prostate Cancer

Abstract: Androgen receptor (AR) signaling not only plays a pivotal role in the development of androgen-dependent prostate cancer but is also important in the growth and survival of castration-resistant prostate cancer (CRPC). The first line of treatment of androgen-dependent prostate cancer is the use of androgen deprivation therapy. However, most patients will eventually relapse due to development of CRPC. Thus, development of a strategy to target AR for treatment of CRPC is urgently needed. The authors have previousl… Show more

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Cited by 35 publications
(26 citation statements)
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“…cDNAs were prepared after digestion with RNase-free RQ1 DNase (Promega). The cDNAs were subjected to real-time reverse transcription-PCR (RT-PCR) using Sso Fast Eva Green Supermix (Bio-Rad) according to the manufacturer's instructions and as described previously (25). Each reaction was normalized by co-amplification of actin.…”
Section: Methodsmentioning
confidence: 99%
“…cDNAs were prepared after digestion with RNase-free RQ1 DNase (Promega). The cDNAs were subjected to real-time reverse transcription-PCR (RT-PCR) using Sso Fast Eva Green Supermix (Bio-Rad) according to the manufacturer's instructions and as described previously (25). Each reaction was normalized by co-amplification of actin.…”
Section: Methodsmentioning
confidence: 99%
“…40 AG is reported to interfere with the binding of hsp90 with other proteins and promote Hsp90 degradation. 41,42 On the other hand, this effect of AG on p21 levels could be due to its enhanced degradation by other factors. 43 In either case, it is clear that despite low levels of p21 AG is capable of arresting PCa cell cycle by affecting the cyclin/CDK complexes.…”
Section: Discussionmentioning
confidence: 95%
“…Furthermore, for the most part study designs were not optimal and suffered limitations such as low animal numbers. In addition to these in vivo studies, one report details how AG can affect androgen signalling in prostate cancer cell lines (Liu et al, 2011). This study indicates an ability of AG to reduce AR expression at the transcriptional level, inhibit nuclear translocation of AR, inhibit the formation of stabilizing complexes with the cochaperone Hsp90, slow the growth of C4-2 prostate cancer cells, and induce apoptosis.…”
Section: Example Risk Assessmentmentioning
confidence: 96%