Andropause: Hormone Replacement Therapy in the Ageing Male

Comhaire, Frank

doi:10.1159/000020358

Cited by 56 publications

(38 citation statements)

References 42 publications

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“…63 A "roller coaster" effect can also occur, characterized by alternating periods of symptomatic benefit and a return to base-line symptoms, corresponding to the fluctuations in serum testosterone levels. 64,65 However, in our experience many males eventually prefer this form of therapy to the others. Compared with conventional testosterone enanthate or cypionate treatment requiring injection intervals of 2 to 3 weeks, and resulting in supraphysiological serum testosterone levels, injections of testosterone undecanoate (TU) at intervals of up to 3 months offer an excellent alternative for substitution therapy of male hypogonadism.…”

Section: Intramuscular Injectionmentioning

confidence: 73%

The benefits and risks of testosterone replacement therapy: a review

Bassil¹,

Alkaade²,

Morley

2009

TCRM

145

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Section: Intramuscular Injectionmentioning

confidence: 73%

The benefits and risks of testosterone replacement therapy: a review

Bassil¹,

Alkaade²,

Morley

2009

TCRM

145

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“…Fluctuation in testosterone levels can induce so-called 'roller-coaster' effects, which are characterized by alternating periods of symptomatic benefits and returning to baseline symptoms. 36 To overcome these limitations, a new depot intramuscular injection containing 1000 mg of TU has been recently introduced to maintain stable physiological levels of testosterone for 12 weeks. 37 While this long duration of action can create problems if there are complications associated with testosterone therapy, it is an excellent alternative for treating male hypogonadism.…”

Section: Intramuscular Injectionmentioning

confidence: 99%

Testosterone replacement therapy for late-onset hypogonadism: current trends in Korea

Ko¹,

Kim²

2011

Asian J Androl

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Testosterone levels in men older than 40 years can decrease at a rate of 1%-2% per year, and reports show that more than 50% of 80-year-old men have testosterone levels consistent with hypogonadism. Late-onset hypogonadism (LOH) is a clinical and biochemical syndrome associated with advancing age and characterized by typical symptoms of serum testosterone deficiency. In recent decades, the concept of LOH in ageing men has become familiar in European countries and the United States. It is also a topic of interest and debate throughout Korea. However, most of the data regarding advantages or disadvantages of testosterone replacement therapy (TRT) as treatment for LOH have been primarily obtained from studies on Western populations; therefore, studies of the effects of TRT in Asian men, who may have different serum testosterone compared to Western men, are needed. TRT is commonly prescribed in Korea, despite the paucity of studies on the effects of TRT in Asian populations. Data from various TRT studies based on Korean have shown its efficacy in increasing serum testosterone levels and improving subjective symptoms as assessed by questionnaires. Currently, patches and short-acting intramuscular injections are displaced by gels and long-acting formulations. However, to prevent overdiagnosis and overtreatment, indication for TRT should include both low testosterone levels and symptoms and signs of hypogonadism. Keywords: androgens; androgenic agents; late-onset hypogonadism; testosterone replacement therapy INTRODUCTION Late-onset hypogonadism (LOH) is a clinical and biochemical syndrome associated with advancing age resulting from age-related changes in the interactions between hypothalamus/pituitary factors and testicular factors. This syndrome is characterized by typical symptoms of serum testosterone deficiency. Increased longevity and population ageing are expected to result in an increase in the number of men with LOH. Therefore, social interest in testosterone replacement therapy (TRT) has increased over the past few decades.In recent decades, LOH in ageing men has become common in European countries and the United States, 1,2 and it has also attracted interest in Korea. An epidemiological research study conducted via email of 5795 Korean men of at least 40 years of age, using the Androgen Deficiency in Aging Men (ADAM) questionnaire, revealed that 64.6% of respondents had symptoms of LOH, and more than 50% of respondents complained of a decline in erection, endurance and/or sexual desire. When asked whether they intended to undergo TRT, 96% of respondents who complained of erectile dysfunction and decreased endurance and/or sexual desire said that they would accept treatment. 3 To provide appropriate guidelines for investigation, treatment and monitoring of LOH in ageing Korean men, the academic committee of the Korean Society for Aging Male Research released guidelines on LOH in men in 2006. 4 Currently, TRT in Korea is a commonly used LOH treatment modality and is prescribed not only by urologists, but also...

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“…Should there be confirmation, serum measurements of LH and prolactin are suggested. 4,9,15,21,23,24,26 The definitive diagnosis of ADAM is based on the judicious assessment of clinical and laboratory data.…”

Section: Laboratory Assessmentmentioning

confidence: 99%

“…Variations of lab methods should be considered. 2,8,9,15,24 Total circulating testosterone equals the following addition:…”

mentioning

confidence: 99%

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Chapter 4

2003

Int J Impot Res

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Andropause: Hormone Replacement Therapy in the Ageing Male

Cited by 56 publications

References 42 publications

The benefits and risks of testosterone replacement therapy: a review

The benefits and risks of testosterone replacement therapy: a review

Testosterone replacement therapy for late-onset hypogonadism: current trends in Korea

Chapter 4

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