Anemia as a risk factor for childhood asthma

Ramakrishnan, KG; Borade, Ashwin

doi:10.4103/0970-2113.63605

Cited by 40 publications

(36 citation statements)

References 6 publications

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“…Prevalence of iron defi ciency anaemia as per our criteria in present study was 32% in cases and 24% in control group, however, the diff erence was not signifi cant sta s cally though children with iron defi ciency anaemia were at a higher risk of wheeze associated respiratory diseases (OR=1.49; 95% CI 0.62-3.59). This fi nding is in agreement with the observa ons of workers such as Ramakrishnan and Borade in 2010, who reported higher prevalence of asthma among anaemic children as compared to non-anaemic children and also indicated a signifi cant associa on between iron-defi ciency anaemia and respiratory illness 10 .…”

Section: Discussionsupporting

confidence: 81%

Is Iron Deficiency Anaemia, a risk Factor For Wheeze Associated Respiratory Tract Infection in Children?

Agrawal

Gupta

Sodhi

et al. 2015

J. Nepal Paedtr. Soc.

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Introduction: Wheezing is the common in children with cumulative prevalence of almost 50% by the age of 6 yrs. Iron deficiency anaemia is an independent risk factor for lower respiratory tract infections (LRTI), however may also play an important role in wheeze associated respiratory tract infection. The present study aimed at finding a correlation between iron deficiency anaemia and wheeze associated respiratory tract infection. Materials and Methods: This case control study was conducted at a multidisciplinary tertiary care hospital from Jul 2012 to Jun 2013 among children six months to five years and having ≥2 episodes of wheeze associated respiratory tract infections. The clinical presentation and laboratory profile were recorded on a predesigned performa. Iron deficiency anaemia was diagnosed by haemoglobin <11.0 gm%, serum ferritin<12ng/ml and RDW>15%. The statistical analysis was done using SPSS, Version 15.0. Results: A total of 100 children were enrolled in the study, of which 50 cases and 50 matched controls. Majority of subjects in both groups were males (n=31;62%),with male to female ratio of 1.6:1. Proportion of cases with iron deficiency anaemia were higher among cases(32%) as compared to controls(24%) but the difference between two groups was not significant statistically (p=0.373) despite having higher risk(OR=1.49;95% CI=0.62-3.59). Mean monocyte, oeosinophil and absolute oeosinophil count was found to be significantly higher in cases as compared to controls (p<0.05). Conclusion: The present study do not suggest a possible linkage between iron deficiency anemia and wheeze associated respiratory infection, however its role as causative factor needs to be explored through long-term prospective and intervention studies on a large population.J Nepal Paediatr Soc 2014;34(3):195-199 DOI: http://dx.doi.org/10.3126/jnps.v34i3.11378

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Section: Discussionsupporting

confidence: 81%

Is Iron Deficiency Anaemia, a risk Factor For Wheeze Associated Respiratory Tract Infection in Children?

Agrawal

Gupta

Sodhi

et al. 2015

J. Nepal Paedtr. Soc.

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“…17 Ramakrishnan and Borade found that anemia was a risk factor for childhood asthma. 18 Bard et al reported that anemia increased heart rate and cardiac output in BPD patients. 19 We first investigated the relationship between Hb levels in the first few days of life and BPD and the results may help us understand the complicated mechanism of BPD.…”

Section: Discussionmentioning

confidence: 99%

Association between Hemoglobin Levels in the First 3 Days of Life and Bronchopulmonary Dysplasia in Preterm Infants

Duan

Kong

et al. 2016

Amer J Perinatol

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Objective The objective of this study was to determine the association between hemoglobin (Hb) levels in the first 3 days of life and bronchopulmonary dysplasia (BPD) in preterm infants. Study Design The study population comprises 147 neonates with a gestational age (GA) of less than 32 weeks who were admitted to BaYi Children's Hospital Affiliated to Beijing Military General Hospital from January 2014 to May 2015. Hb levels in the first 3 days of life, maternal and infant characteristics, were recorded and then analyzed. Results BPD patients had a lower GA and birth weight than non-BPD patients. Rates of surfactant use, use of early inhalation hormone, days of mechanical ventilation > 2 weeks, and patent ductus arteriosus in BPD patients were higher and have a significant difference. Number of transfusions was higher in BPD patients. Lower Hb levels in the first 3 days of life were also observed in BPD patients. A cutoff value of Hb levels was determined as 155.5 g/L. Hb ≤ 155 g/L in the first 3 days of life was a significant risk factor for BPD. Conclusion Our study demonstrated that lower Hb levels in the first 3 days of life may increase the risk of developing BPD in preterm infants.

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“…Other than the factors identified in previous studies, we considered anemia status as one of the predictor variable. A cohort study conducted on children in age group 2-18 years concluded that anemia is a risk factor for childhood asthma [17]. Therefore, in order to study the impact of hemoglobin level on the onset of asthma among adults, we included this variable in the study.…”

Section: Discussionmentioning

confidence: 99%

Individuals with diabetes are at a higher risk of asthma in India: evidence from the National Family Health Survey-3

Kulkarni

Shinde

2015

Int J Diabetes Dev Ctries

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Asthma is a disease of the lung, and from previous studies, a decrement in lung function was observed in patients with diabetes. These results motivated us to study the prevalence of asthma among diabetics. In this study, we estimated the prevalence of asthma among men and women, and also investigated the risk factors for asthma in diabetic and nondiabetic groups in India. This analysis was based on the National Family Health Survey-3 (NFHS-3) data on 71,776 men aged 15-54 years and 115,642 non-pregnant women aged 15-49 years. X 2 test was used to check the dependency of asthma with different socioeconomic, diet-, and lifestylerelated factors. Logistic regression analysis was used to identify the risk factors for asthma. There is significant (p<0.001) association between diabetes and asthma. Individuals with diabetes are at a higher risk of asthma as compared to those without diabetes. The results of the study revealed that among diabetic women and men, 14.1 and 12.8 % were asthmatic, respectively. In without diabetes group, the prevalence of asthma in men and women was 1.7 and 1.6 %, respectively. Men with diabetes were 8.691 times (95 % CI: 7.154-10.558) and women with diabetes were 10.106 times (95 % CI: 8.455-12.08) more likely to have asthma than those without diabetes. Occasional/never consumption of fish, use of unclean fuel, lower age level, and not living with a partner were significantly (p<0.05) associated with the higher risk of asthma among diabetics.

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Anemia as a risk factor for childhood asthma

Cited by 40 publications

References 6 publications

Is Iron Deficiency Anaemia, a risk Factor For Wheeze Associated Respiratory Tract Infection in Children?

Is Iron Deficiency Anaemia, a risk Factor For Wheeze Associated Respiratory Tract Infection in Children?

Association between Hemoglobin Levels in the First 3 Days of Life and Bronchopulmonary Dysplasia in Preterm Infants

Individuals with diabetes are at a higher risk of asthma in India: evidence from the National Family Health Survey-3

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