Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance

Lenehan, Patrick; Ramudu, Eshwan; Venkatakrishnan, AJ; Berner, Gabriela; McMurry, Reid; O’Horo, John C.; Badley, Andrew D.; Halamka, John; Soundararajan, Venky

doi:10.1016/j.isci.2021.102780

Cited by 5 publications

(5 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another report identified an anemia 1 year prior and during acute illness being strongly associated with post-clearance rehospitalization independent of the intensive care unit admission status or other covariates. Similar finding was with AKI as well [24]. Chronic COVID-19 syndrome, also known as post-COVID-19 or long-COVID-19, developed 23 patients (58%) that is consistent with previous reports [25].…”

Section: Discussionsupporting

confidence: 90%

COVID‐19 in kidney transplant recipients; a DALMATIAN single‐center experience

et al. 2022

View full text Add to dashboard Cite

Introduction We aimed to explore COVID‐19 severity, complications, and outcome predictors in the Dalmatian population of kidney transplant recipients (KTRs). Methods KTRs confirmed with acute COVID‐19 infection until May 2021 were included and followed up for 6 months. Results Out of 50 KTRs average aged 63 years, 36 (72%) were men. Nine (18%) KTRs had no pulmonary infiltration, and twenty‐nine (58%) did not require oxygen supplementation. Bilateral pulmonary infiltrates had 29 (58%) while high‐flow nasal cannula or mechanical ventilation required 8 (16%) KTRs. The mortality rate was 16%. Acute kidney injury developed in 18 (36%), and acute renal replacement therapy required 2 (4%) KTRs. Nine (18%) KTRs were subsequently rehospitalized. Chronic COVID‐19 syndrome reported 23 (58%) KTRs. Conclusions D‐dimers were found to be the key prognostic factor of clinical complications, emphasizing the importance of underlying thrombotic microangiopathy. Optimal immunosuppressant adjusting in KTRs with acute COVID‐19 infection remains to be clarified.

show abstract

Section: Discussionsupporting

confidence: 90%

COVID‐19 in kidney transplant recipients; a DALMATIAN single‐center experience

et al. 2022

View full text Add to dashboard Cite

show abstract

“…1 ). Eventually, 36 studies were included in the present systematic review and 28 were incorporated in the meta-analysis [ 7 , 9 , 11 , [13] , [14] , [15] , [16] , 19 , 20 , 23 , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] ]. Overall, 28 articles were included in phase 1 to determine risk factors and outcome of readmitted COVID-19 patients, and 19 articles were included in phase 2 to determine the cause of readmissions.…”

Section: Resultsmentioning

confidence: 99%

Characteristics, risk factors, and outcomes associated with readmission in COVID-19 patients: A systematic review and meta-analysis

Akbari

Fathabadi

Razmi

et al. 2022

The American Journal of Emergency Medicine

View full text Add to dashboard Cite

Background We aimed to determine the characteristics, risk factors, and outcomes associated with readmission in COVID-19 patients. Methods PubMed, Embase, Web of Science, and Scopus databases were searched to retrieve articles on readmitted COVID-19 patients, available up to September 25, 2021. All studies comparing characteristics of readmitted and non-readmitted COVID-19 patients were included. We also included articles reporting the reasons for readmission in COVID-19 patients. Data were pooled and meta-analyzed using random or fixed-effect models, as appropriate. Subgroup analyses were conducted based on the place and duration of readmission. Results Our meta-analysis included 4823 readmitted and 63,413 non-readmitted COVID-19 patients. The re-hospitalization rate was calculated at 9.3% with 95% Confidence Interval (CI) [5.5%–15.4%], mostly associated with respiratory or cardiac complications (48% and 14%, respectively). Comorbidities including cerebrovascular disease (Odds Ratio (OR) = 1.812; 95% CI [1.547–2.121]), cardiovascular (2.173 [1.545–3.057]), hypertension (1.608 [1.319–1.960]), ischemic heart disease (1.998 [1.495–2.670]), heart failure (2.556 [1.980–3.300]), diabetes (1.588 [1.443–1.747]), cancer (1.817 [1.526–2.162]), kidney disease (2.083 [1.498–2.897]), chronic pulmonary disease (1.601 [1.438–1.783]), as well as older age (1.525 [1.175–1.978]), male sex (1.155 [1.041–1.282]), and white race (1.263 [1.044–1.528]) were significantly associated with higher readmission rates ( P < 0.05 for all instances). The mortality rate was significantly lower in readmitted patients (OR = 0.530 [0.329–0.855], P = 0.009). Conclusions Male sex, white race, comorbidities, and older age were associated with a higher risk of readmission among previously admitted COVID-19 patients. These factors can help clinicians and policy-makers predict, and conceivably reduce the risk of readmission in COVID-19 patients.

show abstract

“…Multiple studies have shown that anemia is an independent risk factor for severity of and length of recovery from COVID-19 [41][42][43][44][45]. Anemia has also been found to be signi cantly associated with COVID-19 mortality.…”

Section: Pre-covid-19 Anemia Effect Modi Cationmentioning

confidence: 99%

Assessing the Prevalence of Anemia Post-COVID-19 Infection in Adult Members of a Southeastern U.S. Integrated Healthcare System

Hudgins,

McDonald,

Bush

et al. 2023

Preprint

View full text Add to dashboard Cite

Background COVID-19 may cause or worsen anemia, leading to fatigue, lower quality of life, increased risk of comorbidities, and significantly associated with worse outcomes in patients hospitalized with COVID-19. Little is known among a community-based population. We aimed to investigate the incidence and risk factors of anemia post-COVID diagnosis in a community-based population. Methods We identified all adult members of KPGA with a confirmed diagnosis of COVID-19 between January 2020 and March 2022 and followed through March 2023. Anemia was defined using hemoglobin (Hgb) labs 180-days (±30-days) and 365-days (±30-days) after COVID-19 diagnosis and sex-specific thresholds. Potential risk factors included demographics and clinical characteristics (defined by diagnosis codes) at the time of COVID-19 diagnosis. Hospitalization with COVID-19 was used as a marker of COVID-19 severity. Logistic regression among individuals not diagnosed with anemia pre-COVID investigated the association between each risk factor and anemia 180- and 365-days post-COVID-19 infection. We stratified fully adjusted model by hospitalization with COVID-19 to assess effect modification. Results We included 3,450 and 3,043 individuals who met the inclusion criteria and had Hgb results available 180- and 365- days post-COVID-19 diagnosis. One-third of our population had anemia 180-days (n=1,100, 32.17%) and 365-days (n=1,007, 33.09%) post-COVID-19, with approximately 11% of the cohort being newly diagnosed cases of anemia. In the fully adjusted models females (vs. males) (OR=1.71, 95% CI: 1.42, 2.06), Black or African American individuals (vs. non-Black individuals) (OR=2.34, 95% CI: 1.98, 2.76), adults diagnosed with kidney disease (OR=1.79, 95% CI: 1.42, 2.25) or diabetes (OR=1.26, 95% CI: 1.12, 1.64), and adults hospitalized with COVID-19 (OR=1.43, 95% CI: 1.15, 1.78) were more likely to be diagnosed with anemia 365-days after COVID-19 diagnosis. Analyses stratified by hospitalization status showed a possible effect modification between hospitalization status and post-COVID-19 anemia. Discussion Our study showed that one in three people in a community-based population have anemia 180-days and 365-days after their first COVID-19 diagnosis. Anemia can cause fatigue, a lingering symptom of COVID-19 infection. Though more research is needed, ongoing surveillance of COVID-19 patients for anemia may be an important component of management of long COVID-19.

show abstract

Anemia during SARS-CoV-2 infection is associated with rehospitalization after viral clearance

Abstract: Patients rehospitalized after SARS-CoV-2 clearance have distinct laboratory test profiles Rehospitalized patients have lower hemoglobin before and during SARS-CoV-2 infection Rehospitalized patients are more likely to experience anemia during active infection

Cited by 5 publications

References 37 publications

COVID‐19 in kidney transplant recipients; a DALMATIAN single‐center experience

COVID‐19 in kidney transplant recipients; a DALMATIAN single‐center experience

Characteristics, risk factors, and outcomes associated with readmission in COVID-19 patients: A systematic review and meta-analysis

Assessing the Prevalence of Anemia Post-COVID-19 Infection in Adult Members of a Southeastern U.S. Integrated Healthcare System

Contact Info

Product

Resources

About