Anemia in thyroid diseases

Szczepanek‐Parulska, Ewelina; Hernik, Aleksandra; Ruchała, Marek

doi:10.20452/pamw.3985

Cited by 79 publications

(85 citation statements)

References 44 publications

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“…On the other hand, as reported in the literature, AIHA and hypothyroidism may appear simultaneously, or may follow each other . They may share common immunological background . In our case, the positive TgAb and TPOAb indicated that hypothyroidism is a manifestation of autoimmune disorders.…”

Section: Discussionsupporting

confidence: 74%

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Severe autoimmune hemolytic anemia during pegylated interferon plus ribavirin treatment for chronic hepatitis C: a case report

Wang

Qin

Zhi

et al. 2017

Clinical Case Reports

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Section: Discussionsupporting

confidence: 74%

“…On the other hand, as reported in the literature, AIHA and hypothyroidism may appear simultaneously, or may follow each other . They may share common immunological background .…”

Section: Discussionmentioning

confidence: 72%

Severe autoimmune hemolytic anemia during pegylated interferon plus ribavirin treatment for chronic hepatitis C: a case report

Wang

Qin

Zhi

et al. 2017

Clinical Case Reports

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“…In the biochemical landscape of thyroid dysfunction, iron (Fe) homeostasis abnormalities are frequently observed (1,2). The prevalence of anaemia in overt hyperthyroidism was found to be higher (14.6%) than in overt hypothyroidism (7.7%), subclinical thyroid dysfunctions (3.3-5%) and the euthyroid state (4.7%) according to a large cohort study (3).…”

Section: Introductionmentioning

confidence: 99%

Changes in serum hepcidin according to thyrometabolic status in patients with Graves’ disease

Krygier

Szczepanek‐Parulska

Filipowicz

et al. 2020

Endocrine Connections

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Introduction:Hepcidin is an acute-phase protein and a key regulator of iron homeostasis. Anaemia frequently occurs in patients with thyroid dysfunction, and hepcidin may be a potential link. Objectives: Prospective assessment of hepcidin serum concentration and other parameters related to Fe homeostasis in hyperthyroid patients in the course of GD at diagnosis and during remission. Patients and Methods: Out of the 70 patients recruited, 42 (32 women, 10 men), aged 42.5 ± 15.1 years, met the inclusion criteria. Clinical and biochemical assessment, including hepcidin measurement by ELISA, was performed at baseline (T0) and after restoration of euthyroidism (T1). Results: Hepcidin concentration at T0 in the 24 patients who completed the study was significantly higher than the value during euthyroidism (28.7 (8.1-39.4) ng/mL vs 7.9 (4.3-12.9) ng/mL, P < 0.001). Hepcidin level was most significantly correlated with ferritin (rho = 0.723) in women at T0. In both men (377 (171-411) vs 165 (84-237) ng/mL, P = 0.001) and women (84 (23-104) vs 35 (16-64) ng/mL, P = 0.001), a significant decrease in ferritin level was demonstrated following therapy. A significant (P < 0.001) increase in mean corpuscular volume (MCV) (83.5 (82.5-87.1) vs 89.5 (88.8-90.0) fL) and mean concentration of haemoglobin (MCH) (29.0 (28.0-29.4) vs 30.4 (29.5-31.1) pg) was observed. Conclusions: Hepcidin and ferritin decrease significantly during the transition from a hyperthyroid state to euthyroidism in patients with GD. The observed changes occur in parallel to iron homeostasis fluctuations. During the transition from the hyperthyroid state to euthyroidism, the improvement of haematological status is reflected mainly by the increase in MCV and MCH. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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“…Гормоны щитовидной железы стимулируют пролиферацию предшественников эритроцитов как непосредственно, так и путем повышения выработки эритропоэтина, тогда как железодефицитная анемия отрицательно влияет на состояние гормонов щитовидной железы. Таким образом, при дисфункции щитовидной железы могут развиваться различные формы анемии [15,17]. Имеются отдельные работы, в которых представлены лабораторные параметры анемического синдрома у больных ДТЗ: при гипертиреозе анемия чаще является нормоцитарной и нормохромной (нормальный уровень MCV и MCH) [1,5,11,17].…”

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“…Таким образом, при дисфункции щитовидной железы могут развиваться различные формы анемии [15,17]. Имеются отдельные работы, в которых представлены лабораторные параметры анемического синдрома у больных ДТЗ: при гипертиреозе анемия чаще является нормоцитарной и нормохромной (нормальный уровень MCV и MCH) [1,5,11,17]. По данным других авторов для тиреотоксикоза характерен микроцитоз [16].…”

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