Anemia is associated with an elevated serum level of high-molecular-weight adiponectin in patients with type 2 diabetes independently of renal dysfunction

Aso, Yoshimasa; Suganuma, Ruriko; Wakabayashi, Shigeo; Hara, Kenji; Nakano, Takashi; Suetsugu, Mariko; Matsumoto, Sachiko; Nakamachi, Takafumi; Takebayashi, Kohzo; Morita, Kimio; Iwamoto, Toshihiko

doi:10.1016/j.trsl.2009.07.005

Cited by 28 publications

(36 citation statements)

References 39 publications

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“…The number of women studied for eGFRcys and other variables was 159 and 361, respectively. lesterol in non-obese, elderly women, as previously reported in patients with type 2 diabetes 23) and those with coronary artery disease 24) . Circulating adiponectin levels have been shown to be elevated in patients (see Ref.…”

Section: As Shown Insupporting

confidence: 59%

“…The present findings suggest that anemia and renal dysfunction are important and independent confounders of elevated circulating adiponectin in elderly women. Few studies have examined associations between plasma adiponectin concentration and hemoglobin or anemia [22][23][24] . Matsubara et al 22) found an inverse association between adiponectin and red blood cell counts in healthy Japanese women aged from 20 to 74 years old; however, they did not report the association in separate age groups.…”

Section: Discussionmentioning

confidence: 99%

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Anemia and Reduced Renal Function are Independent Predictors of Elevated Serum Adiponectin in Elderly Women

Tsuboi

Watanabe

Kazumi

et al. 2013

JAT

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Aim: Although higher adiponectin levels predict a low risk of type 2 diabetes, elevated adiponectin levels predict higher mortality in older persons. Methods: We examined the associations of adiponectin with anthropometric, metabolic and hematological variables and renal function in 361 community-dwelling elderly women aged 76±8. Renal function was assessed using the estimated glomerular filtration rate (eGFR).

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Section: As Shown Insupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Anemia and Reduced Renal Function are Independent Predictors of Elevated Serum Adiponectin in Elderly Women

Tsuboi

Watanabe

Kazumi

et al. 2013

JAT

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“…Anemia was associated with marked elevation of serum total and HMW adiponectin level, and this elevation was independent of renal function. The level of plasma total adiponectin negatively correlates with Hb in CKD with and without diabetes (20). Furthermore, a significant positive correlation between serum HMW adiponectin and erythropoietin level was clearly demonstrated in the current series.…”

Section: Discussionsupporting

confidence: 68%

“…BNP is synthesized in the ventricular myocardium in response to ventricular stretching and wall stress (18), and plasma BNP levels have prognostic potential for patients with end-stage renal disease (ESRD) (19). The elevation of HMW adiponectin is also associated with anemia in CKD patients with diabetes (20). Anemia is common in patients with ESRD and is a risk factor for adverse outcome (21).…”

Section: Introductionmentioning

confidence: 99%

Total and HMW Adiponectin is Independently Associated with B-type Natriuretic Peptide and Anemia in Chronic Hemodialysis Patients

Abe

Matsumae²,

Eto

et al. 2012

Intern. Med.

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Objective A number of vasculo-protective roles have been reported for adiponectin. In contrast, higher, rather than lower, plasma adiponectin levels are associated with an increased risk of cardiovascular disease and mortality in patients undergoing hemodialysis (HD). The mechanisms by which high adiponectin levels are associated with adverse outcome are unclear. Methods This study measured the level of total and high molecular weight (HMW) adiponectins in 70 patients with HD patients (age: 65.2±8.6 years, man/woman: 30/40), and examined the association between adiponectins, metabolic and echocardiographic parameters. Results Women had a significantly higher total, HMW levels and HMW to total ratio than men. The levels of total and HMW adiponectin were positively correlated with those of HDL-cholesterol and B-type natriuretic peptide (BNP) levels, and negatively associated with body mass index (BMI), triglyceride, high sensitive-C reactive protein (CRP) and hemoglobin levels. A multiple linear regression analysis showed that HMW adiponectin had an independent association with BMI (β=-0.270, p=0.003), HDL-cholesterol (β= 0.356, p<0.001), hemoglobin (β=-0.180, p=0.034) and BNP (β=0.200, p=0.014) as total did adiponectin. Conclusion Anemia and BNP levels had independent influence on the total and HMW adiponectin levels in chronic HD patients.

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“…The current study aimed to investigate whether hemoglobin was independently associated with the serum level of high-molecular-weight (HMW) adiponectin. To our knowledge, few studies have demonstrated a relationship between hematological parameters, such as hemoglobin and serum HMW adiponectin 15,16) . We hypothesized that hematological parameters are associated with serum HMW adiponectin regardless of insulin resistance and body weight.…”

Section: Introductionmentioning

confidence: 99%

Hemoglobin is Associated with Serum High Molecular Weight Adiponectin in Japanese Community-Dwelling Persons

Kawamoto

Tabara

Kohara

et al. 2011

JAT

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Anemia is associated with an elevated serum level of high-molecular-weight adiponectin in patients with type 2 diabetes independently of renal dysfunction

Cited by 28 publications

References 39 publications

Anemia and Reduced Renal Function are Independent Predictors of Elevated Serum Adiponectin in Elderly Women

Anemia and Reduced Renal Function are Independent Predictors of Elevated Serum Adiponectin in Elderly Women

Total and HMW Adiponectin is Independently Associated with B-type Natriuretic Peptide and Anemia in Chronic Hemodialysis Patients

Hemoglobin is Associated with Serum High Molecular Weight Adiponectin in Japanese Community-Dwelling Persons

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