1964
DOI: 10.1097/00000542-196411000-00013
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Anesthesia and the Liver

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Cited by 37 publications
(6 citation statements)
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“…Potent intrinsic hepatotoxins have been largely excluded from the clinical armamentarium. Half a century ago, however, the direct hepatotoxin, carbon tetrachloride, was employed as a vermifuge [16], and until a few years ago, chloroform continued to be used for anesthesia in some areas [27]. Tannic acid, employed for the treatment of burns four decades ago, was discarded from that use when it was identified as the cause of hepatic necrosis in patients [4], only to reassert its toxicity two decades later as the necrogenic additive to barium sulfate suspensions used in colonic radiography [30].…”
Section: Drugs As Intrinsic Hepatotoxinsmentioning
confidence: 99%
“…Potent intrinsic hepatotoxins have been largely excluded from the clinical armamentarium. Half a century ago, however, the direct hepatotoxin, carbon tetrachloride, was employed as a vermifuge [16], and until a few years ago, chloroform continued to be used for anesthesia in some areas [27]. Tannic acid, employed for the treatment of burns four decades ago, was discarded from that use when it was identified as the cause of hepatic necrosis in patients [4], only to reassert its toxicity two decades later as the necrogenic additive to barium sulfate suspensions used in colonic radiography [30].…”
Section: Drugs As Intrinsic Hepatotoxinsmentioning
confidence: 99%
“…They found the primary site of the cholestasis to be in the liver cell, possibly in the membrane of the bile canaliculus and in the pericanalicular ectoplasm. In addition to biliary stasis, portal cellular infiltration is frequently seen (LITTLE and WETSTONE, 1964;READ, 1965).…”
Section: Introductionmentioning
confidence: 99%
“…'Αποστόλου ευχαριστώ θερμώς δια τήν έπιμέλειαν καί διόρθωσιν των χειρογράφων καί εν γένει διά τήν άμέριστον συμπαράστασιν της εις τήν έκπόνησιν τής πα ρούσης διατριβής. ΕΙΣΑΓΩΓΗ Ώς γνωστόν τά πλείστα των αναισθητικών φαρμάκων δύνανται να θεωρηθούν ώς προιτοπλασματικά δηλητήρια 57,28 . "Αλλα εξ αυτών ήσσονος και άλλα εξ αυτών μείζονος ισχύος.…”
Section: προλογοςunclassified
“…Ή ήπατοτοξικότης των αναισθητικών φαρμάκων άπησχόλησεν ιδιαιτέρως τους έρευνητάς. Άφ' ής δέ το πρώτον διεπιστώθη και περιεγράφη ή τοξικότης του χλωροφορμίου το 1894 υπό του Cuthrie, L. G. καί τίνων ετέρων γερμανών συγγραφέων εις προγενέστερον χρόνον 28 , δια τήν είσαγωγήν οιουδήποτε νέου αναισθη τικού παράγοντος εις τήν καθ' ήμέραν πραξιν απαραίτητος προϋπόθεσις θεωρείται ή κατά το δυνατόν ελαχίστη ήπατοτοξικότης αυτού.…”
Section: αναισθητικα -ηπατοτοξικοτηςunclassified
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