Anesthesia Techniques and Long-Term Oncological Outcomes

Ramirez, María F.; Cata, Juan P.

doi:10.3389/fonc.2021.788918

Cited by 17 publications

(15 citation statements)

References 174 publications

(154 reference statements)

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“…In 2021, Ramirez et al performed a review describing how drugs may regulate important function on immune and cancer cells [92]. The authors presented several preclinical and clinical studies and explained the effects of anesthetics on cancer cells.…”

Section: Anesthetic Agents Volatile and Intravenous Anestheticsmentioning

confidence: 99%

Anesthesia and cancer recurrence: an overview

Brogi

Forfori

2022

J Anesth Analg Crit Care

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Several perioperative factors are responsible for the dysregulation or suppression of the immune system with a possible impact on cancer cell growth and the development of new metastasis. These factors have the potential to directly suppress the immune system and activate hypothalamic-pituitary-adrenal axis and the sympathetic nervous system with a consequent further immunosuppressive effect.Anesthetics and analgesics used during the perioperative period may modulate the innate and adaptive immune system, inflammatory system, and angiogenesis, with a possible impact on cancer recurrence and long-term outcome. Even if the current data are controversial and contrasting, it is crucial to increase awareness about this topic among healthcare professionals for a future better and conscious choice of anesthetic techniques.In this article, we aimed to provide an overview regarding the relationship between anesthesia and cancer recurrence. We reviewed the effects of surgery, perioperative factors, and anesthetic agents on tumor cell survival and tumor recurrence.

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Section: Anesthetic Agents Volatile and Intravenous Anestheticsmentioning

confidence: 99%

Anesthesia and cancer recurrence: an overview

Brogi

Forfori

2022

J Anesth Analg Crit Care

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“…The conflicting results of the pro and antitumoral effects on cancer cells might be explained by differences in experimental conditions, such as type of cell line, incubation time (range from 30 min to 6 h), type, and especially the concentration of volatile anesthetics (range between 0.5 and 10%). For instance, some studies treated cancer cells with extremely high concentrations that are unlikely to be employed in clinical practice, and perhaps, the “antitumortumoural” effect is related to the use of toxic concentrations of volatile anesthetics [ 108 ].…”

Section: The Perioperative Effects Of Anesthetics On Cancer Recurrencementioning

confidence: 99%

Influence of Perioperative Anesthesia on Cancer Recurrence: from Basic Science to Clinical Practice

Xia

Zhou

et al. 2022

Curr Oncol Rep

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Purposeof Review In this review, we will summarize the effects of these perioperative anesthetics and anesthetic interventions on the immune system and tumorigenesis as well as address the related clinical evidence on cancer-related mortality and recurrence. Recent Findings Cancer remains a leading cause of morbidity and mortality worldwide. For many solid tumors, surgery is one of the major therapies. Unfortunately, surgery promotes angiogenesis, shedding of circulating cancer cells, and suppresses immunity. Hence, the perioperative period has a close relationship with cancer metastases or recurrence. In the perioperative period, patients require multiple anesthetic management including anesthetics, anesthetic techniques, and body temperature control. Preclinical and retrospective studies have found that these anesthetic agents and interventions have complex effects on cancer outcomes. Therefore, well-planned, prospective, randomized controlled trials are required to explore the effects of different anesthetics and techniques on long-term outcomes after cancer surgery. Summary Due to the conflicting effects of anesthetic management on cancer recurrence, further preclinical and clinical trials are required and beneficial to the development of systemic cancer therapies.

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“…Of course, in many cases a combination of intravenous and inhalation anaesthesia is also used. Total intravenous anesthesia is a method of administering anesthesia to patients using intravenous anesthetics and its auxiliary agents with the advantages of rapid induction, smooth anesthesia, no contamination and quicker awakening (Ramirez and Cata, 2021). Propofol has been the basis of TIVA, with the development of target-controlled infusion (TCI) system, TCI has the advantages of fast adjustment speed, strong controllability and stable anesthesia depth, which is conducive to the personalized and refined administration of propofol, and can effectively avoid the sedation or anesthesia of too deep or too shallow due to individual differences and changes in surgical stimulation intensity (Anderson and Bagshaw, 2019).…”

Section: Total Intravenous Anesthesiamentioning

confidence: 99%

An intravenous anesthetic drug-propofol, influences the biological characteristics of malignant tumors and reshapes the tumor microenvironment: A narrative literature review

Zhou

Shao

et al. 2022

Front. Pharmacol.

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Malignant tumors are the second leading cause of death worldwide. This is a public health concern that negatively impacts human health and poses a threat to the safety of life. Although there are several treatment approaches for malignant tumors, surgical resection remains the primary and direct treatment for malignant solid tumors. Anesthesia is an integral part of the operation process. Different anesthesia techniques and drugs have different effects on the operation and the postoperative prognosis. Propofol is an intravenous anesthetic that is commonly used in surgery. A substantial number of studies have shown that propofol participates in the pathophysiological process related to malignant tumors and affects the occurrence and development of malignant tumors, including anti-tumor effect, pro-tumor effect, and regulation of drug resistance. Propofol can also reshape the tumor microenvironment, including anti-angiogenesis, regulation of immunity, reduction of inflammation and remodeling of the extracellular matrix. Furthermore, most clinical studies have also indicated that propofol may contribute to a better postoperative outcome in some malignant tumor surgeries. Therefore, the author reviewed the chemical properties, pharmacokinetics, clinical application and limitations, mechanism of influencing the biological characteristics of malignant tumors and reshaping the tumor microenvironment, studies of propofol in animal tumor models and its relationship with postoperative prognosis of propofol in combination with the relevant literature in recent years, to lay a foundation for further study on the correlation between propofol and malignant tumor and provide theoretical guidance for the selection of anesthetics in malignant tumor surgery.

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Anesthesia Techniques and Long-Term Oncological Outcomes

Cited by 17 publications

References 174 publications

Anesthesia and cancer recurrence: an overview

Anesthesia and cancer recurrence: an overview

Influence of Perioperative Anesthesia on Cancer Recurrence: from Basic Science to Clinical Practice

An intravenous anesthetic drug-propofol, influences the biological characteristics of malignant tumors and reshapes the tumor microenvironment: A narrative literature review

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