Anesthetic protocol: propofol use in Rhesus macaques (Macaca mulatta) during magnetic resonance imaging with stereotactic head frame application

Fowler, K.; Huerkamp, Michael J; Pullium, Jennifer K; Subramanian, Thyagarajan

doi:10.1016/s1385-299x(00)00051-9

Cited by 21 publications

(13 citation statements)

References 4 publications

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“…A grande vantagem do uso do propofol em relação à cetamina em primatas não humanos é o menor tempo de recuperação anestésica e uma melhor recuperação pós-operatória (AUTHIER et al, 2006). Outras propriedades favoráveis ao seu uso são a redução do laringoespasmo durante a intubação orotraqueal, mínima náusea e mínimo movimento involuntário (FOWLER et al, 2001;BRANSON, 2007). Neste estudo a administração intramuscular de midazolam (1mg/kg) promoveu sedação leve com relaxamento muscular.…”

Section: Discussionunclassified

“…O propofol é classificado como um derivado alquifenol sedativo-hipnótico intravenoso que ganhou grande popularidade na prática veterinária e humana devido as suas propriedades desejáveis na anestesia injetável (FOWLER et al, 2001). O propofol pode ser usado como agente indutor e na manutenção da anestesia de primatas não humanos (FOWLER et al, 2001, FLECKNELL;RICHARDSON;POPOVIC, 2007).…”

Section: Introductionunclassified

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Avaliação eletrocardiográfica de macacos-prego (Sapajus apella) sob contenção química com midazolam e propofol

et al. 2013

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ResumoEstudos sobre eletrocardiograma (ECG) em Sapajus apella são restritos na literatura científica. Primatas não humanos podem ser sedados com benzodiazepínicos e após induzidos e mantidos anestesiados com propofol. O objetivo do presente estudo foi à descrição dos achados eletrocardiográficos em 18 macacos-prego (Sapajus apella) após sedação com midazolam e anestesia com propofol. A interpretação do eletrocardiograma foi realizada determinando-se os seguintes parâmetros: frequência (FC) e ritmo cardíaco, eixo elétrico (°), onda P, onda R, onda T, complexo QRS, intervalo P-R, intervalo Q-T e segmento ST. A FC média foi de 198,4 ± 22,9 bpm, a maioria dos macacos tinham ritmo sinusal normal, seguido de ritmo sinusal normal com marcapasso migratório. O eixo elétrico mais comumente observado manteve-se entre 60-90°. A administração intramuscular de midazolam, seguida de anestesia geral de curta ação com propofol não causou arritmias no traçado eletrocardiográfico e preservou a FC nos limites considerados fisiológicos para a espécie. Consequentemente, houve uma duração maior do intervalo Q-T comparado com estudos anteriores que utilizaram somente cetamina. Palavras-chave: Sapajus apella, propofol, midazolam, eletrocardiograma AbstractStudies on electrocardiography in Sapajus apella are restricted in the scientific literature. Nonhuman primates can be sedated with benzodiazepine and after induced and maintained anesthetized with propofol. The objective of the present study was to description of the electrocardiographic findings in 18 capuchin monkeys (Sapajus apella) after sedation with midazolam and anesthesia with propofol. The interpretation of the ECG was performed by determining the following parameters: frequency (HR) and heart rhythm, electrical axis (°) P wave, R wave, T wave, QRS complex, P-R interval, Q-T interval and ST segment. The HR mean was 198,4 ± 22,9 bpm, the majority of monkeys had normal sinus rhythm, followed by normal sinus rhythm with wandering pacemaker. The most commonly observed electrical axis was between 60-90°. Intramuscular administration of midazolam, followed by a shortacting general anesthesia with propofol did not cause arrhythmias in electrocardiographic tracing and preserved the FC in the limits considered physiological for to specie. Consequently, there was a longer

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Section: Discussionunclassified

Section: Introductionunclassified

Avaliação eletrocardiográfica de macacos-prego (Sapajus apella) sob contenção química com midazolam e propofol

et al. 2013

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“…However, the availability of basic pharmacologic information concerning propofol in NHP, especially in macaques, is limited. Fowler et al. (2001) reported a dose regimen for propofol in rhesus macaques (Fowler et al.…”

Section: Introductionmentioning

confidence: 99%

Hypnotic effects and pharmacokinetics of a single bolus dose of propofol in Japanese macaques (Macaca fsucata fsucata)

Miyabe‐Nishiwaki

Masui

Kaneko

et al. 2010

Veterinary Anaesthesia and Analgesia

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“…Briefly, prior to MRI and stereotaxic frame application, after the animal is sedated with glycopyrolate and tiletamine/zolazepam, a catheter was placed into the cephalic vein in the leg of the monkey to administer intravenous anesthesia. In order to induce anesthesia, undiluted propofol is administered to the monkey (9). Vocal cords were sprayed with xylocaine to prevent involuntary muscular contraction of the laryngeal cords and intubated.…”

Section: Methodsmentioning

confidence: 99%

Quadrature RF coil for in Vivo brain MRI of a macaque monkey in a stereotaxic head frame

Roopnariane

Ryu

Tofighi

et al. 2012

Concepts Magn Reson

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We present a quadrature volume coil designed for brain imaging of a macaque monkey fixed in a sphinx position (facing down the bore) within a stereotactic frame at 3 T, where the position of the monkey and presence of the frame preclude use of existing coils. Requirements include the ability to position and remove the coil without disturbing the position of the monkey in the frame. A saddle coil and a solenoid were combined on a modified cylindrical former and connected in quadrature as to produce a homogeneous circularly polarized field throughout the brain. To allow the loops of the saddle coil to encompass the ear posts, partial disassembly and reassembly were facilitated by embedding pin and socket contacts into separate pieces of the former. Coil design included simulation of the electromagnetic fields for the coil containing a 3D model of a monkey’s head. The resulting coil produced adequate homogeneity and signal-to-noise ratio throughout the brain.

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Anesthetic protocol: propofol use in Rhesus macaques (Macaca mulatta) during magnetic resonance imaging with stereotactic head frame application

Cited by 21 publications

References 4 publications

Avaliação eletrocardiográfica de macacos-prego (Sapajus apella) sob contenção química com midazolam e propofol

Avaliação eletrocardiográfica de macacos-prego (Sapajus apella) sob contenção química com midazolam e propofol

Hypnotic effects and pharmacokinetics of a single bolus dose of propofol in Japanese macaques (Macaca fsucata fsucata)

Quadrature RF coil for in Vivo brain MRI of a macaque monkey in a stereotaxic head frame

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