Anethole and eugenol reduce in vitro and in vivo leukocyte migration induced by fMLP, LTB4, and carrageenan

Estevão-Silva, Camila Fernanda; Kummer, Raquel; Fachini-Queiroz, Fernanda Carolina; Grespan, Renata; Melo, Gessilda Alcântara Nogueira de; Baroni, Silmara; Cuman, Roberto Kenji Nakamura; Bersani-Amado, Ciomar Aparecida

doi:10.1007/s11418-014-0839-7

Cited by 35 publications

(26 citation statements)

References 52 publications

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“…Since EST treatment did not affect the leukocytes viability evaluated by cytotoxicity assay at all concentrations tested (data not shown), our data suggest that the direct effect of EST on inhibition of leukocyte migration does not seem to be related to toxic effects (e.g., cell death). Recent study performed in our laboratory showed that both anethole and eugenol (structural analog of EST) reduced leukocyte migration induced by fMLP, probably by inhibitory effects of these compounds on synthesis/release cytokines [23]. …”

Section: Resultsmentioning

confidence: 99%

“…Recently it was demonstrated by our research group that anethole decreased the acute inflammatory process by inhibiting some mediators such as NO, PGE 2 , TNF, IL-1 β , and IL-17 and it was also able to inhibit leukocyte migration in vitro and in vivo [7, 9, 23]. Indeed, EST presented inhibitory activity on paw edema induced by TNF- α in mice [10].…”

Section: Resultsmentioning

confidence: 99%

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Effect of Estragole on Leukocyte Behavior and Phagocytic Activity of Macrophages

Silva-Comar

Wiirzler

Silva-Filho

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Estragole, a chemical constituent of the essential oils of many aromatic plants, is used as flavoring in beverage and food industries. In vivo and in vitro experimental assays have shown that EST has sedative, anticonvulsant, antioxidant, antimicrobial, and anesthetic activity. In this work, we evaluate the effect of EST on leukocyte behavior and phagocytic activity of macrophages. In the peritonitis model, EST (500 and 750 mg/kg) decreased the infiltration of peritoneal exudate leukocytes. In vitro chemotaxis assay showed that EST (3, 10, 30, and 60 μg/mL) inhibited neutrophil migration toward fMLP. In the in vivo microcirculation assay, EST at doses of 250, 500, and 750 mg/kg significantly reduced the number of rolling and adherent leukocytes and at doses of 250 and 500 mg/kg decreased number of leukocyte migrated to perivascular tissue. The results showed that EST (3, 10, and 30 μg/mL) was able to stimulate the macrophages phagocytosis but only at concentration of 10 μg/mL promoted an increase in nitric oxide (NO) production. In conclusion, this study showed that EST had potential anti-inflammatory effects, likely by inhibiting leukocyte migration and by stimulating macrophages phagocytosis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Effect of Estragole on Leukocyte Behavior and Phagocytic Activity of Macrophages

Silva-Comar

Wiirzler

Silva-Filho

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…They have also found that the oil of star anise is stimulant, stomachic, carminative, mildy expectorant and diuretic. It has been also reported that the fruit of the plant has been used in traditional medicine for treatment of stomach aches, vomiting, rheumatic pain, insomnia and skin inflammation (Sung et al, 2012;Wang et al, 2011;Estevao-Silva et al, 2014;Park et al, 2015). Aly et al (2014) mentioned that its fruit is an important traditional Chinese medicine as well as a commonly used spice.…”

Section: Introductionmentioning

confidence: 99%

Chinese star anise and anise, magic herbs in traditional Chinese medicine and modern pharmaceutical science

Shahrajabian

Sun

Cheng

2019

Asian J. Med. Biol. Res

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Star anise (Illicium verum Hook. f.) is an important herb in traditional Chinese medicine as well as traditional Asian medicine. The fruit is aromatic and has a strong, pungent and mildly sweet taste. Star anise is one of the many species that contain bioactive compounds as well as a number of phenolic and flavonoid compounds, having antioxidant, preservative and antimicrobial properties. All relevant papers in the English language from researchers of different countries were collected. The keywords of Chinese star anise, anise, traditional Chinese medicine and modern pharmaceutical science were searched in Google Scholar, Scopus, Research Gate and PubMed. Its seeds are good source of minerals like calcium, iron, copper, potassium, manganese, zinc, and magnesium. The essential oil of Chinese star anise contains anethole which has shown several functional properties including antimicrobial, antioxidant, hypoglycemic, hypolipidemic and oestrogenic properties. Due to all positive characteristics, such as antidiabetic, hypolipidemic, antioxidant activities, anticancer and antimicrobial properties, both seeds and essential oils of anise is promising for safe use as super food supplements and raw constituents in the both pharmaceutical and food industries. Anise seed oil contains anethol, estragole, eugenol, pseudisoeugenol, methyl chavicol and anisaldehyde, coumarins, scopoleting, umbelliferon, estrols, terpene hydrocarbons, and polyacetylenes as the major compounds. The plant oil has both pharmacological and clinical effects. The pharmacological effects consist of antimicrobial, hepatopreotective, anticonvulsant, anti-inflammatory, antispasmodic, bronchodilator, estrogenic, expectorant and insecticidal effects, and clinical effects such as nausea, constipation, menopausal period, virus, diabetes, obesity and sedative action. Combined with a nutritious diet, other traditional Chinese and Asian medicine, Chinese star anise and ansie seed may improve various aspects of health. More clinical studies are necessary to uncover the numerous substances and their effects in ginseng that contribute to public health. Asian J. Med. Biol. Res. June 2019, 5(3): 162-179

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“…This oil has demonstrated to possess different biological properties, such as antimicrobial, analgesic, anti-inflammatory, antioxidant, antimutagenic, and anticarcinogenic effects [3, 12]. Recent in vivo studies have explored the potential anticancer property of eugenol, demonstrating the induction of apoptosis in several cancer cell lines from animal tumor models [4, 13].…”

Section: Introductionmentioning

confidence: 99%

Effect of 4-Allyl-1-hydroxy-2-methoxybenzene (Eugenol) on Inflammatory and Apoptosis Processes in Dental Pulp Fibroblasts

Martínez-Herrera

Pozos‐Guillén

Ruiz-Rodríguez

et al. 2016

Mediators of Inflammation

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Eugenol (mixed with zinc oxide powder) is widely used as direct capping material during pulp therapy in primary teeth. The aim of the present study was to evaluate the effect of eugenol on diverse genes involved in inflammatory and cell apoptosis processes. The regulatory effect of eugenol on the expression of inflammation and apoptotic genes was evaluated in dental pulp fibroblasts from extracted third molars, cultured under concentration of eugenol of 13 μM. Eugenol allowed the expression of inflammatory and apoptotic genes when compared with positive and negative controls. Eugenol is a proinflammatory agent when it is in direct contact with healthy tissues and behaves as an anti-inflammatory agent in tissues undergoing inflammatory/apoptotic processes, as in cases of pulp inflammation in primary teeth. These findings are relevant for dentistry, when considering the application of safer pulp treatments to grossly carious children's teeth.

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Anethole and eugenol reduce in vitro and in vivo leukocyte migration induced by fMLP, LTB4, and carrageenan

Cited by 35 publications

References 52 publications

Effect of Estragole on Leukocyte Behavior and Phagocytic Activity of Macrophages

Effect of Estragole on Leukocyte Behavior and Phagocytic Activity of Macrophages

Chinese star anise and anise, magic herbs in traditional Chinese medicine and modern pharmaceutical science

Effect of 4-Allyl-1-hydroxy-2-methoxybenzene (Eugenol) on Inflammatory and Apoptosis Processes in Dental Pulp Fibroblasts

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