Anetoderma Associated With a Succinate Dehydrogenase Gene Mutation

Brys, Adam K.; Rodriguez-Homs, Larissa G; Wennerberg, Samantha; Hall, Russell P.; Nicholas, Matilda W.

doi:10.1001/jamadermatol.2019.2579

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…It was found that Lyso PC can reduce the MG 63 osteoblast-like cell activity in a concentration-dependent manner. Lyso PC can also induce MG 63 osteoblast-like cell necrosis and apoptosis, and its cytotoxic effect is related to intracellular calcium homeostasis destruction (Brys et al, 2019). Corticosterone, estriol, and LysoPC (15: 0) of model animals were all down-regulated in this study indicating the occurrence of osteoporosis.…”

mentioning

confidence: 53%

High-Throughput Metabolomics Discovers Metabolic Biomarkers and Pathways to Evaluating the Efficacy and Exploring Potential Mechanisms of Osthole Against Osteoporosis Based on UPLC/Q-TOF-MS Coupled With Multivariate Data Analysis

Zhou

Shen

et al. 2020

Front. Pharmacol.

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Postmenopausal osteoporosis (PMOP) is the most common metabolic bone illness among the elderly especially in postmenopausal women resulting from a reduction in bone mineral density, but there is no effective drug at present. The study was aimed at evaluating efficacy of osthole against osteoporosis using high-throughput metabolomics method. The blood samples for illustrating the pathological mechanism of PMOP and exploring the efficacy of osthole treatment (ST) were collected to perform metabolites and metabolic profiles and pathways analysis using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) and pattern recognition methods. In addition, backbone weight, the bone density, and some vital biochemical indexes were also detected. A total of 28 metabolites were identified as biomarkers for ovariectomized-osteoporosis model, and ST could significantly regulate 19 of them including lysine, linoleic acid, 3-hydroxybutyric acid, prostaglandin F2a, taurocholic acid, LysoPC(15:0), l -carnitine, glucose, arginine, citric acid, corticosterone, ornithine, tryptophan, arachidonic acid, Cer(d18:0/18:0), glutamine, uric acid, 8-HETE, estriol, which mainly related with 13 metabolic pathways, such as linoleic acid metabolism, starch, and sucrose metabolism, arachidonic acid metabolism, alanine, aspartate and glutamate metabolism, arginine and proline metabolism, citrate cycle (TCA cycle), and arginine biosynthesis. The ovariectomized model (OVX) rats display a significant decrease bone density, TGF-β1, NO, and NOS level, and a significant increase bone weight, IL-6, TNF-α, and Ca 2+ level. These parameters in the ST rats were evidently improved as compared to the OVX group. ST effectively mitigated ovariectomy-induced osteoporosis in rats by affecting endogenous metabolite-related metabolic mechanism and showed the natural alternative with potential for the treatment of PMOP.

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mentioning

confidence: 53%

High-Throughput Metabolomics Discovers Metabolic Biomarkers and Pathways to Evaluating the Efficacy and Exploring Potential Mechanisms of Osthole Against Osteoporosis Based on UPLC/Q-TOF-MS Coupled With Multivariate Data Analysis

Zhou

Shen

et al. 2020

Front. Pharmacol.

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“…LPC is a class of PC‐derived components transformed from PC by phospholipase A2, which is a calcium/calmodulin‐regulated protein (Deng et al, 2021). Research has reported that LPC can initiate pro‐inflammatory activity and induce apoptosis of osteoclasts (Brys et al, 2019). High levels of LPC may be associated with increased phospholipase A2 enzyme activity owing to calcium and phosphorus metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…Research has reported that LPC can initiate pro-inflammatory activity and induce apoptosis of osteoclasts (Brys et al, 2019). High levels of LPC may be associated with increased phospholipase A2 enzyme activity owing to calcium and phosphorus metabolism.…”

Section: Analysis Of Potential Biomarkersmentioning

confidence: 99%

UPLC/Q‐TOF–MS‐based metabolomics evaluate the efficacy of oroxylin A against postmenopausal osteoporosis

Xian

Nong

Gao

et al. 2023

Biomedical Chromatography

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Post-menopausal osteoporosis (PMOP) is a common metabolic bone malady characterized by bone mass loss and bone microarchitectural deterioration; however, there is currently no effective drug for its management. According to our previous study, oroxylin A (OA) could effectively protect ovariectomized (OVX)osteoporotic mice from bone loss; however, its therapeutic targets are still unclear. From a metabolomic perspective, we studied serum metabolic profiles to discover potential biomarkers and OVX-related metabolic networks, which could assist us to comprehend the impact of OA on OVX. Five metabolites were identified as biomarkers associated with 10 related metabolic pathways, including phenylalanine, tyrosine and tryptophan biosynthesis, and phenylalanine, tryptophan and glycerophospholipid metabolism. After OA treatment, the expression of multiple biomarkers changed, with lysophosphatidylcholine (18:2) being a major significantly regulated biomarker. Our study demonstrated that OA's effects on OVX are probably related to the regulation of phenylalanine, tyrosine and tryptophan biosynthesis. Our findings explain the role of OA against PMOP in terms of metabolism and pharmacology and provide a pharmacological foundation for OA treatment of PMOP.

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“…The results implied that PLA2 enzyme activity is decreased due to disorders of calcium and phosphorus metabolism, leading to a decrease in LPC, LPE and free fatty acid (FFA) levels. Studies have shown that LPC has pro-inflammatory activity and promotes osteoblast apoptosis (Brys et al, 2019). The accumulation of LPC in bone tissue may lead to the decrease of serum LPC.…”

Section: Discussionmentioning

confidence: 99%

An Integrated Metabolomic Study of Osteoporosis: Discovery and Quantification of Hyocholic Acids as Candidate Markers

Deng

Chen

Wu³

et al. 2021

Front. Pharmacol.

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Osteoporosis is becoming a highly prevalent disease in a large proportion of the global aged population. Serum metabolite markers may be important for the treatment and early prevention of osteoporosis. Serum samples from 32 osteoporosis and 32 controls were analyzed by untargeted metabolomics and lipidomic approaches performed on an ultra-high performance liquid chromatography and high-resolution mass spectrometry (UHPLC-HRMS) system. To find systemic disturbance of osteoporosis, weighted gene correlation network analysis (WGCNA) and statistical methods were employed for data-mining. Then, an in-depth targeted method was utilized to determine potential markers from the family of key metabolites. As a result, 1,241 metabolites were identified from untargeted methods and WGCNA indicated that lipids metabolism is deregulated and glycerol phospholipids, sphingolipids, fatty acids, and bile acids (BA) are majorly affected. As key metabolites of lipids metabolism, 66 bile acids were scanned and 49 compounds were quantified by a targeted method. Interestingly, hyocholic acids (HCA) were found to play essential roles during the occurrence of osteoporosis and may be potential markers. These metabolites may be new therapeutic or diagnosis targets for the screening or treatment of osteoporosis. Quantified measurement of potential markers also enables the establishment of diagnostic models for the following translational research in the clinic.

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Anetoderma Associated With a Succinate Dehydrogenase Gene Mutation

Cited by 4 publications

References 7 publications

High-Throughput Metabolomics Discovers Metabolic Biomarkers and Pathways to Evaluating the Efficacy and Exploring Potential Mechanisms of Osthole Against Osteoporosis Based on UPLC/Q-TOF-MS Coupled With Multivariate Data Analysis

High-Throughput Metabolomics Discovers Metabolic Biomarkers and Pathways to Evaluating the Efficacy and Exploring Potential Mechanisms of Osthole Against Osteoporosis Based on UPLC/Q-TOF-MS Coupled With Multivariate Data Analysis

UPLC/Q‐TOF–MS‐based metabolomics evaluate the efficacy of oroxylin A against postmenopausal osteoporosis

An Integrated Metabolomic Study of Osteoporosis: Discovery and Quantification of Hyocholic Acids as Candidate Markers

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