Aneurysmal bone cyst. A review of 123 cases including primary lesions and those secondary to other bone pathology

Martínez, Virginia; Sissons, H. A.

doi:10.1002/1097-0142(19880601)61:11<2291::aid-cncr2820611125>3.0.co;2-v

Cited by 354 publications

(184 citation statements)

References 29 publications

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“…7,9 Interestingly, an inversion of chromosome 17 [inv(17)(p13q11.2-12)] involving similar breakpoints was observed in case 37 of the present study (Figure 3). Although rearrangements of the 17q12 band have not been reported as [3],del(7)(q32) [3],À9 [3],+12 [2],+13 [2], inv(16)(p13.1q24) [4],À17 [3],À19 [4],À20 [3] Current study prominent in mesenchymal tumors, the 17q12 locus has received considerable attention because of the localization of the Her-2neu (a.k.a. c-erbB-2, erythroblastic leukemia viral oncogene homolog 2) and RARA (retinoic acid receptor, alpha) genes to this chromosomal band.…”

Section: Discussionmentioning

confidence: 99%

“…Aneurysmal bone cyst most commonly arises in young patients and typically involves the metaphyseal region of long bones and vertebrae. 2,3 Histopathologically, the lesion is composed of varying sized blood-filled spaces separated by connective tissue septa containing bony trabeculae and giant osteoclastic cells. 4 Aneurysmal bone cysts are frequently locally aggressive and exhibit a strong tendency to recur.…”

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Cytogenetic and molecular cytogenetic findings in 43 aneurysmal bone cysts: aberrations of 17p mapped to 17p13.2 by fluorescence in situ hybridization

et al. 2004

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Aneurysmal bone cyst is a benign, cystic lesion of bone composed of blood-filled spaces separated by fibrous septa. Relatively few cases of aneurysmal bone cyst have been cytogenetically characterized, yet abnormalities of the short arm of chromosome 17 appear to be recurrent. In this study, conventional cytogenetic analysis of 43 aneurysmal bone cyst specimens from 38 patients over a 12-year period revealed clonal chromosomal abnormalities in 12 specimens. Karyotypic anomalies of 17p, including a complex translocation and inversion, were identified in eight of these 12 specimens. In an effort to further define the aberrant 17p breakpoint, fluorescence in situ hybridization (FISH) analyses were performed using a series of probe combinations spanning a 5.1 Mb region between the TP53 (17p13.1) and Miller-Dieker lissencephaly syndrome (17p13.3) gene loci. These studies revealed the critical breakpoint locus at 17p13.2, flanked proximally by an RP11-46I8, RP11-333E1, and RP11-457I18 bacterial artificial chromosome (BAC) probe cocktail and distally by an RP11-198F11 and RP11-115H24 BAC and RP5-1050D4 P1 artificial chromosome (PAC) probe cocktail. Overall, abnormalities of the 17p13.2 locus were identified by metaphase and/or interphase cell FISH analysis in 22 of 35 (63%) aneurysmal bone cyst specimens examined including 26 karyotypically normal specimens. These cytogenetic and molecular cytogenetic findings expand our knowledge of chromosomal alterations in aneurysmal bone cyst, further localize the critically involved 17p breakpoint, and provide an alternative approach (ie FISH) for detecting 17p abnormalities in nondividing cells of aneurysmal bone cysts. The latter could potentially be utilized as an adjunct in diagnostically challenging cases.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Cytogenetic and molecular cytogenetic findings in 43 aneurysmal bone cysts: aberrations of 17p mapped to 17p13.2 by fluorescence in situ hybridization

et al. 2004

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“…ABCs also occur secondary to other bone tumors such as chondroblastomas, giant cell tumor, chondromyxoid fibroma, non-ossifying fibromas, or fibrous dysplasia [6,7]. These secondary ABCs account for nearly 30 % of all ABCs, and they are not considered a neoplasm because no known translocation or genetic aberrancy is present [7].…”

Section: Abcs Secondary To Other Bone Tumorsmentioning

confidence: 99%

“…These secondary ABCs account for nearly 30 % of all ABCs, and they are not considered a neoplasm because no known translocation or genetic aberrancy is present [7].…”

Section: Abcs Secondary To Other Bone Tumorsmentioning

confidence: 99%

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Current management of aneurysmal bone cysts

Park

Yang

Sheppard

et al. 2016

Curr Rev Musculoskelet Med

190

259

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Aneurysmal bone cysts (ABCs) are benign bone lesions arising predominantly in the pediatric population that can cause local pain, swelling, and pathologic fracture. Primary lesions, which constitute roughly two thirds of all ABCs, are thought to be neoplastic in nature, with one third of ABCs arising secondary to other tumors. Diagnosis is made with various imaging modalities, which exhibit characteristic features such as Bfluid-fluid levels,^although biopsy is critical, as telangiectatic osteosarcoma cannot be excluded based on imaging alone. Currently, the standard of care and most widely employed treatment is intralesional curettage. However, tumor recurrence with curettage alone is common and has driven some to propose a multitude of adjuvants with varying efficacy and risk profiles. Historically, therapies such as en bloc resection or radiation therapy were utilized as an alternative to decrease the recurrence rate, but these therapies imposed high morbidity. As a result, modern techniques now seek to simultaneously reduce morbidity and recurrence, the pursuit of which has produced preliminary study into minimally invasive percutaneous treatments and medical management.

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Malignant transformation of aneurysmal bone cyst, with an analysis of the literature

Kyriakos

Hardy

1991

Cancer

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An 11‐year‐old girl had a lytic, benign‐appearing, expansive lesion of the distal tibia radiologically interpreted as an aneurysmal bone cyst (ABC). Tissue from two extensive curettage procedures was also histologically diagnosed as ABC. Approximately 50 months after the onset of symptoms, and 28 months after her last curettage, a highly pleomorphic osteosarcoma developed. The patient had not received prior radiation therapy. The cases in the literature of possible malignant transformation of ABC are reviewed. The authors separate their case from telangiectatic osteosarcoma, and from “ aneurysmal bone cyst‐like osteosarcoma”.

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Aneurysmal bone cyst. A review of 123 cases including primary lesions and those secondary to other bone pathology

Cited by 354 publications

References 29 publications

Cytogenetic and molecular cytogenetic findings in 43 aneurysmal bone cysts: aberrations of 17p mapped to 17p13.2 by fluorescence in situ hybridization

Cytogenetic and molecular cytogenetic findings in 43 aneurysmal bone cysts: aberrations of 17p mapped to 17p13.2 by fluorescence in situ hybridization

Current management of aneurysmal bone cysts

Malignant transformation of aneurysmal bone cyst, with an analysis of the literature

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