Aneurysmal bone cyst: a review

Nasri, Elham; Reith, John D.

doi:10.4132/jptm.2023.02.23

Cited by 16 publications

(10 citation statements)

References 36 publications

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“…[ 25 ] However, today, due to molecular findings such as the TRE17/USP6 gene (abnormalities of the short arm of chromosome 17), ABC tumors are considered neoplasms. [ 3 , 4 , 31 , 33 , 49 ] Spinal ABC tumors can present with nocturnal pain. Patients may also experience paresthesia, paresis, or radicular pain extending to the lower extremities, abdomen, or chest wall.…”

Section: Discussionmentioning

confidence: 99%

Management of aggressive recurrent thoracic spine aneurysmal bone cyst in a 7-year-old male: A case report and review of the literature

Jahangiri,

Roohollahi,

Habibi

et al. 2024

Surgical Neurology International

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Background: Spinal aneurysmal bone cysts (ABCs) are rare, histologically benign tumors with aggressive behavior, which may cause bone and soft-tissue destruction, particularly affecting neural elements. Management of these tumors, including treatment modalities and follow-up protocols, remains challenging. Case Description: A 7-year-old boy presented with chest wall pain persisting for two months before admission, accompanied by progressive mono paresis lasting ten days before admission. Myelopathy signs were evident during the examination. Imaging confirmed a multicystic lesion at the T6 level involving the posterior elements of the vertebra, with significant cord compression. Due to deteriorating neurological function, he underwent urgent laminectomy and neural decompression, followed by subtotal tumor resection. Postoperative histopathological examination confirmed the diagnosis of an ABC, and the patient experienced significant neurological recovery. However, after 21 days, the patient was readmitted to the emergency department with severe paraparesis. Magnetic resonance imaging revealed rapid growth of the residual tumor, leading to cord compression. He underwent aggressive total tumor resection, T6 vertebral body corpectomy, and fixation with pedicle screws and cage insertion. Following the second surgery, prompt neurological recovery occurred. Conclusion: This rare case report emphasizes the importance of a close follow-up protocol for spinal ABCs in the pediatric population. It highlights the challenges in managing these tumors and the need for vigilant monitoring to detect and address rapid recurrences.

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Section: Discussionmentioning

confidence: 99%

Management of aggressive recurrent thoracic spine aneurysmal bone cyst in a 7-year-old male: A case report and review of the literature

Jahangiri,

Roohollahi,

Habibi

et al. 2024

Surgical Neurology International

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“…However, a USP6 gene rearrangement study is of help in differentiating them because ABC is a true neoplasm-inducing USP6 gene rearrangement. [ 5 , 7 ]…”

Section: Discussionmentioning

confidence: 99%

“…The condition is rare, accounting for 2.5% of all bone tumors. [ 5 ] The occurrence of ABC does not differ by sex, and in most cases, it occurs in the first 2 decades of life, when the skeletal system is not yet fully developed. [ 6 ] Previously, ABC was believed to occur as a reaction to traumas or a reactive lesion due to underlying vascular events.…”

Section: Introductionmentioning

confidence: 99%

“…In current opinion, however, it is regarded as a true neoplasm due to the rearrangement of the ubiquitin-specific peptidase 6 (USP6 ) gene. [ 5 , 7 ]…”

Section: Introductionmentioning

confidence: 99%

“…The changes occur due to the disruption of osseous circulation caused by comorbidity and are typically found in giant cell tumors, chondroblastoma, osteoblastoma, osteosarcoma, chondromyxoid fibroma, and fibrous dysplasia. [ 5 , 8 ] Therefore, in cases where ABC-like changes are dominant, thorough sampling and careful examination should be performed, considering that an underlying bone tumor is masquerading.…”

Section: Introductionmentioning

confidence: 99%

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Intraosseous hemangioma with aneurysmal bone cyst-like changes of the hyoid bone: Case report and literature review

Oh,

Han,

Lim

2024

Medicine

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Rationale: Intraosseous hemangioma is a rare benign vascular tumor of the bone that can affect any body part; however, the most common site is the vertebra, followed by calvarial bones. Patient concerns: We present a case of intraosseous hemangioma in a 23-year-old male who presented a feeling of fullness in the throat for 3 months. The hyoid bone level had a hard mass of about 5 cm. Fine needle aspiration showed 5 mL dark bloody aspirates. Magnetic resonance image showed a 5.3 cm mixed signal intensity lesion in the hyoid body. Diagnosis: Histopathologic examination showed intraosseous hemangioma with aneurysmal bone cyst (ABC)-like changes in the hyoid bone. Interventions: The mass was completely removed without significant problems. Outcomes: Complete mass excision and symptomatic improvements were achieved, and no subsequent relapses were observed. Lessons: The authors experienced a case of intraosseous hemangioma with ABC-like changes. There has been no case report of intraosseous hemangioma in the hyoid bone. This case showed a spectral pattern of the ABC-like changes developing from the underlying bone tumor as a secondary change. ABC-like changes in bone tumors can mislead the diagnosis. Careful examination of the tumor is essential for the correct diagnosis of ABC or ABC-like changes.

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Long‐Term Outcomes of Temporal Bone Aneurysmal Bone Cysts: Ambispective Study With Systematic Review and Pooled Analysis

Das K,

Mehrotra,

Keshri

et al. 2024

Otolaryngol.--head neck surg.

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ObjectiveTo analyse the clinical, radiological, and surgical management of temporal bone aneurysmal bone cysts (ABCs) and identify factors affecting outcomes.Study DesignAmbispective study.SettingA single tertiary care institution.MethodsThis study reviewed 6 cases of temporal bone ABCs treated between 2017 and 2024. Patient demographics, clinical presentation, imaging characteristics, surgical details, and outcomes were collected. A systematic review of the literature was conducted, adhering to Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines, to compare institutional cases with published data. Statistical analyses were performed to identify predictors of treatment success and recurrence.ResultsThe cohort had a mean age of 27.5 years. Presenting symptoms included scalp swelling, aural fullness, tinnitus, and hearing impairment. Imaging showed expansile lesions with fluid‐fluid levels and bone erosion. All patients underwent gross total excision, with a mean intraoperative blood loss of 230.6 ml. One patient experienced temporary grade III facial palsy, which resolved within 3 months. No recurrences were observed during a mean follow‐up of 35 months. A pooled analysis of 45 cases from the literature revealed that swelling in the temporal region was the most common presenting feature, and gross total resection was the most frequently employed treatment. Recurrences were rare and typically associated with subtotal resections or advanced‐stage tumors.ConclusionSurgical excision, particularly gross total resection, is the treatment of choice for temporal bone ABCs, with a low recurrence rate. Stage and extent of resection are critical factors in predicting outcomes. This study enhances understanding of the diagnostic and therapeutic approaches for this rare condition.

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Aneurysmal bone cyst: a review

Cited by 16 publications

References 36 publications

Management of aggressive recurrent thoracic spine aneurysmal bone cyst in a 7-year-old male: A case report and review of the literature

Management of aggressive recurrent thoracic spine aneurysmal bone cyst in a 7-year-old male: A case report and review of the literature

Intraosseous hemangioma with aneurysmal bone cyst-like changes of the hyoid bone: Case report and literature review

Long‐Term Outcomes of Temporal Bone Aneurysmal Bone Cysts: Ambispective Study With Systematic Review and Pooled Analysis

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