Aneurysmal bone cysts.A clinicopathologic study of 66 cases

Abstract

Sixty‐six cases of aneurysmal bone cyst were reviewed clinically, pathologically and radiologically. Different therapies, including curettage, block excision, amputation and radiation therapy, and a new treatment, cryosurgery, were employed. Cryosurgery, which avoids the growth and neoplastic complications of radiation therapy and the loss of bone with block excision, had an extremely low rate of recurrence when compared to simple curettage. In manometric studies of 6 cysts, 3 had elevated vascular pressures as high as arteriolar levels. Thirty‐two percent of the aneurysmal bone cysts had an accompanying benign primary lesion of bone. Based on these findings, a new hypothesis for the etiology and pathogenesis of aneurysmal bone cysts was proposed: a primary lesion of bone initiates an osseous, arteriovenous fistula and thereby creates, via its hemodynamic forces, the secondary reactive lesion of bone, which we term aneurysmal bone cyst.

Cytogenetic and molecular cytogenetic findings in 43 aneurysmal bone cysts: aberrations of 17p mapped to 17p13.2 by fluorescence in situ hybridization

“…7,9 Interestingly, an inversion of chromosome 17 [inv(17)(p13q11.2-12)] involving similar breakpoints was observed in case 37 of the present study (Figure 3). Although rearrangements of the 17q12 band have not been reported as [3],del(7)(q32) [3],À9 [3],+12 [2],+13 [2], inv(16)(p13.1q24) [4],À17 [3],À19 [4],À20 [3] Current study prominent in mesenchymal tumors, the 17q12 locus has received considerable attention because of the localization of the Her-2neu (a.k.a. c-erbB-2, erythroblastic leukemia viral oncogene homolog 2) and RARA (retinoic acid receptor, alpha) genes to this chromosomal band.…”

“…2,3 Histopathologically, the lesion is composed of varying sized blood-filled spaces separated by connective tissue septa containing bony trabeculae and giant osteoclastic cells. 4 Aneurysmal bone cysts are frequently locally aggressive and exhibit a strong tendency to recur. 5 Relatively few cases of aneurysmal bone cyst have been cytogenetically characterized.…”

Current management of aneurysmal bone cysts

“…Despite best efforts at curettage, clinical series have shown highly variable recurrence rates, with some series showing rates as high as 59 % [29]. As a result, various adjuvants have evolved to reduce recurrence including the use of cement, high-speed burr, argon beam, phenol, and cryotherapy.…”

Conversion of Aneurysmal Bone Cyst into Fibrous Dysplasia: A Rare Pediatric Case Report

“…Five months after the third surgery, the patient assisted to a follow-up appointment with hemifacial contour deformity and intraoral swelling again, suggesting pathology recurrence (Figs. 4,5). Once more, surgical correction was performed intraorally, but this time, after raising a mucoperiosteal flap over the remnant alveolar ridge, the lesion showed osseous consistency without evidence of soft tissue, and the previously inserted reconstruction plate was almost covered by bone (Fig.…”

“…The etiopathogenesis of this entity remains controversial, but it has been described as a consequence of traumatism, as hemodynamic alteration, or as a secondary phenomenon associated to the presence of primary bone lesions [4]. It can be classified as primary or secondary, depending on the presence or absence of associated preexisting histopathological conditions, such as the ossifying fibroma or the central giant cell granuloma, among others, being the first and the most frequently involved [5].…”