Angiogenesis and its control in the female reproductive system

Abstract

The rapid, controlled and cyclical nature of angiogenesis in the female reproductive tract suggests that interference with this process should provide a novel approach to manipulation of reproductive function. Many factors involved in the regulation of angiogenesis have been identified, and the possibility of stimulating or inhibiting these paracrine control mechanisms is being addressed using current advances in the development of angiogenic and anti-angiogenic compounds. Studies with animal models indicate that the normal processes of folliculogenesis, ovulation and corpus luteum function in the ovary, and the control of menstruation and implantation in the endometrium could be profoundly influenced by manipulation of angiogenesis. Novel therapeutic agents targeted to the angiogenic pathway may also have a wide range of applications in pathological processes in the reproductive tract such as cancer, endometriosis, fibroid growth, and ovarian hyperstimulation syndrome.

Prolactin in Ovarian Follicular Fluid Stimulates Endothelial Cell Proliferation

“…The ability of FF to induce angiogenesis has been demonstrated previously in other mammalian species [34] and was mainly attributed to proangiogenic factors such as VEGF and bFGF [24]. However, not all the angiogenic activity of FF is due to these factors [35].…”

Vascular Endothelial Growth Factor and Angiogenesis

“…After ovulation, VEGF-A mRNA and protein expression are observed in granulosa-derived luteal cells. VEGF-A expression in the corpus luteum appears highest early in 560 the luteal phase and declines after the mid-luteal phase, with little or no expression in the late corpus luteum (Fraser and Lunn, 2000). Neutralization of VEGF-A during the early luteal phase inhibits the development of the normally extensive capillary bed.…”

A adhesive process after surgical treatment for ovarian apoplexy: Prevention and treatment

“…Среди известных факторов, контролирующих про-цесс васкуляризации овариальной ткани, основным и наиболее изученным является сосудисто-эндотелиальный фактор роста (СЭФР) [11][12][13][14][15][16]. Установлено, что в яични-ке СЭФР играет важную роль в циклическом ангиогенезе, начиная с менархе и вплоть до менопаузы.…”