Angiogenesis as a prognostic factor of pathological stage IA lung adenocarcinoma: developing an angiogenic score

Abstract

Purpose: This work was designed to correlate the expression of markers of tumoral angiogenesis in lung adenocarcinoma as a prognostic factor and create a predictive model with these factors.Patients and methods: A clinical, observational and analytical research study was undertaken. This work sought to describe and compare prognosis value of angiogenic markers of 119 resected patients, classified as pathological stage IA. The tumour angiogenesis analysis was performed, the survival and predictive value of microvascular density (MVD) expression with tumoral relapse and survival were evaluated. Finally, an accurate score, "Angioscore", was calculated by combining different markers.Results: Low MVD-CD34 is associated with a worse disease-free survival (DFS) and cancer specific survival (CSS). High MVD-CD31 is significantly related to reduce DFS and CSS. High MVC-CD105 is associated with worse clinical outcomes. The predictive capacity of these angiogenic markers independently it is not exact. The "Angioscore" is able to provide better information about patient prognosis (74.8% and 73.7%). Two groups were obtained with the risk value obtained by "Angioscore". A significant difference in the prognosis of both groups was accomplished (p < 0.001). Being in the multivariate analysis the only independent prognostic factor in patients with lung ADC in stage IA of this series. Conclusion:Tumour angiogenesis is a prognostic factor in early stage lung adenocarcinoma, the analysis of this factor being more accurate using a score, with great predictive value for the prognosis of patients.Prognostic factors aim to predict the probability of an event occurring in cancer, mortality or relapse. However, a single factor is not usually helpful for this purpose. Therefore, it is necessary to create predictive models or risk scores that include a combination of prognostic factors, and to more precisely approach the probability of the event under study. This work was designed to investigate and correlate the expression of markers of tumoural angiogenesis in lung ADC as a prognostic factor in resected patients classified as pathological stage IA according to the 8th edition of the TNM classification to establish risk groups, and to create a new score that better stratifies patients with stage IA lung ADC.De Aguiar-Quevedo K (2020) Angiogenesis as a prognostic factor of pathological stage IA lung adenocarcinoma: developing an angiogenic score