Angiogenesis in brain contusion

Kobek, Mariusz; Skowronek, Rafał; Jankowski, Zbigniew; Pałasz, Artur

doi:10.5114/amsik.2015.53227

Cited by 2 publications

(1 citation statement)

References 21 publications

(47 reference statements)

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“…because the vascular supply is interrupted while others are compromised by plasma enzymes (e.g., thrombin and plasmin) (93). The temporal course of histologic changes has been described in several detailed studies and reviews (15,79,80,(94)(95)(96)(97)(98). Note that there is some variability in the observations; this could reflect the patient populations studied or the criteria used for reporting cellular details.…”

Section: Invited Reviewmentioning

confidence: 99%

Histology of Brain Trauma and Hypoxia-Ischemia

Rahaman¹,

Bigio²

2018

Academic Forensic Pathology

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Forensic pathologists encounter hypoxic-ischemic (HI) brain damage or traumatic brain injuries (TBI) on an almost daily basis. Evaluation of the findings guides decisions regarding cause and manner of death. When there are gross findings of brain trauma, the cause of death is often obvious. However, microscopic evaluation should be used to augment the macroscopic diagnoses. Histology can be used to seek evidence for TBI in the absence of gross findings, e.g., in the context of reported or suspected TBI. Estimating the survival interval after an insult is often of medicolegal interest; this requires targeted tissue sampling and careful histologic evaluation. Retained tissue blocks serve as forensic evidence and also provide invaluable teaching and research material. In certain contexts, histology can be used to demonstrate nontraumatic causes of seemingly traumatic lesions. Macroscopic and histologic findings of brain trauma can be confounded by concomitant HI brain injury when an individual survives temporarily after TBI. Here we review the histologic approaches for evaluating TBI, hemorrhage, and HI brain injury. Amyloid precursor protein (APP) immunohistochemistry is helpful for identifying damaged axons, but patterns of damage cannot unambiguously distinguish TBI from HI. The evolution of hemorrhagic lesions will be discussed in detail; however, timing of any lesion is at best approximate. It is important to recognize artifactual changes (e.g., dark neurons) that can resemble HI damage. Despite the shortcomings, histology is a critical adjunct to the gross examination of brains.

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Section: Invited Reviewmentioning

confidence: 99%

Histology of Brain Trauma and Hypoxia-Ischemia

Rahaman¹,

Bigio²

2018

Academic Forensic Pathology

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Pathogenetic mechanisms of mild traumatic brain injury in patients of different ages

Kurikeru,

Muravskiy,

Huk

2021

ECM

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This study was carried out to reveal the influence of mechanical energy, which triggers a whole cascade of pathological and compensatory processes of different depth and duration in the brain in traumatic brain injury (TBI). One of the most common consequences of TBI is impaired working memory – the ability to temporarily hold small pieces of information necessary for current mental activity. The aim of the work is to study the relationship between the TBI mechanism and the types of brain damage, as well as the consequences of trauma in patients of different ages. 95 case histories of patients with closed TBI were studied. All patients were treated in the Neurosurgical department of the Emergency hospital, Chernivtsi. Among them were 76 men and 19 women. The study found that TBI of patients in most cases was obtained as a result of traffic and others accidents. All patients had closed TBI. Contusion foci in all age groups were equally identified in the frontal, temporal and occipital lobes, less in the parietal lobe. The incidence of contusion increased slightly with increasing age of patients. In the presence of hemorrhages in patients, hemiparesis and liquor-hypertensive syndrome occurred. In men, TBI was more common than in women, and was expressed as moderate brain contusion, subacute and chronic compression of the brain. This TBI development was more common in young patients. It is promising to further study the nature of combined TBI in people of all ages and analyze the results of specialized neurosurgical care. Keywords: traumatic brain injury, neurosurgical care, liquor-hypertensive syndrome.

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Angiogenesis in brain contusion

Cited by 2 publications

References 21 publications

Histology of Brain Trauma and Hypoxia-Ischemia

Histology of Brain Trauma and Hypoxia-Ischemia

Pathogenetic mechanisms of mild traumatic brain injury in patients of different ages

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