Angiogenesis in two animal models of osteoarthritis

Mapp, P.I.; Avery, Paul S.; McWilliams, Daniel F.; Bowyer, Jonathan; Day, C. Andrew; Moores, S. R.; Webster, R.; Walsh, David A.

doi:10.1016/j.joca.2007.05.017

Cited by 109 publications

(84 citation statements)

References 24 publications

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“…Angiogenesis, which is the growth of new capillaries from preexisting blood vessels, is an essential feature of OA [29][30][31]. We found less β1,4-GalT-I expression in normal cartilage and synovial tissue.…”

Section: Discussionmentioning

confidence: 56%

Elevated Expression of β1,4-Galactosyltransferase-I in Cartilage and Synovial Tissue of Patients with Osteoarthritis

et al. 2011

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Osteoarthritis (OA) is considered a complex illness, characterized by cartilage degeneration, secondary synovial membrane inflammation, and subchondral bone sclerosis. Previous studies have shown β1,4-galactosylransferase-I (β1,4-GalT-I) to be a key inflammatory mediator that participates in the initiation and maintenance of inflammatory reaction in diseases. In the present study, we investigated the expression and possible biological function of β1,4-GalT-I in the cartilage and synovial tissue of OA patients. Cartilage and synovial tissue samples from OA patients and healthy controls were stained for β1,4-GalT-I. Reverse transcription-polymerase chain reaction was used to observe the expression of β1,4-GalT-I, and western blot was carried out for E-selectin. The interaction between β1,4-GalT-I and E-selectin was analyzed by double labeling immunohistochemistry and immunoprecipitation. The expression of β1,4-GalT-I increased in the cartilage and synovial tissue of OA patients compared with healthy controls. E-selectin was overexpressed and was correlated with β1,4-GalT-I in OA cartilage and synovial tissue. These data suggest that β1,4-GalT-I may play an important role in the inflammatory processes in cartilage and synovial tissue of patients with OA.

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Section: Discussionmentioning

confidence: 56%

Elevated Expression of β1,4-Galactosyltransferase-I in Cartilage and Synovial Tissue of Patients with Osteoarthritis

et al. 2011

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“…24 This osteochondral angiogenesis may potentiate joint damage by stimulating ossification in the OA cartilage. [25][26][27][28][29] Furthermore, VEGF may directly increase catabolic pathways in cartilage tissue by activating matrix metalloproteinase and reducing tissue metalloproteinase inhibitors, additionally to indirect effect such as osteochondral angiogenesis. 15,16,30,31 VEGF was also reported to play a critical role in endochondral ossification.…”

Section: Discussionmentioning

confidence: 99%

Localization of vascular endothelial growth factor during the early stages of osteochondral regeneration using a bioabsorbable synthetic polymer scaffold

Sakata

Kokubu

Nagura

et al. 2011

Journal Orthopaedic Research

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Vascular endothelial growth factor (VEGF) plays a critical role in chondrogenic differentiation in the growth plate of the epiphysis. This function is necessary for chondrocyte survival in cartilage development. We investigated the localization of VEGF in the osteochondral regeneration process using a bioabsorbable polymer scaffold. Osteochondral defects (5 mm in diameter and 5 mm in depth) were made on the femoral condyle of forty-eight skeletally mature female Japanese white rabbits. In total, twenty-four defects were filled with poly(DL-lactide-co-glycolide) scaffolds and the others were left untreated. The regeneration process was investigated macroscopically, histologically, immunohistochemically, and by gene expression analysis. In the early stages of osteochondral regeneration, bone ingrowth was observed in the deep zone of the scaffold with continuous VEGF expression; cartilage regeneration was observed in the superficial zone of the scaffold with decreased VEGF expression. In contrast, when the defect was left untreated, VEGF localization was observed throughout the entire defect area, and cartilage regeneration at the articular surface was delayed. We conclude that decrease in localization of VEGF at the articular surface in the postoperative early stage is closely related to the progression of cartilage regeneration in osteochondral defects. ß

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“…Vascular invasion might occur constantly during the progression of OA or it might surge in a specific phase of OA. A few animal studies implicated the early vascular invasion 5,6 , but the longitudinal change of the vascular invasion at the osteochondral junction has been unknown.…”

Section: Introductionmentioning

confidence: 99%

Angiogenic activity of subchondral bone during the progression of osteoarthritis in a rabbit anterior cruciate ligament transection model

Saito

Sasho

Yamaguchi

et al. 2012

Osteoarthritis and Cartilage

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Angiogenesis in two animal models of osteoarthritis

Cited by 109 publications

References 24 publications

Elevated Expression of β1,4-Galactosyltransferase-I in Cartilage and Synovial Tissue of Patients with Osteoarthritis

Elevated Expression of β1,4-Galactosyltransferase-I in Cartilage and Synovial Tissue of Patients with Osteoarthritis

Localization of vascular endothelial growth factor during the early stages of osteochondral regeneration using a bioabsorbable synthetic polymer scaffold

Angiogenic activity of subchondral bone during the progression of osteoarthritis in a rabbit anterior cruciate ligament transection model

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