Angiogenic Potential and Its Modifying Interventions in Dental Pulp Stem Cells: a Systematic Review

Badodekar, Nilaja; Mishra, Smriti; Telang, Gaurang; Chougule, Shruti; Bennur, Darpan; Thakur, Mansee; Vyas, Nishant

doi:10.1007/s40883-022-00270-1

Cited by 1 publication

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References 86 publications

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“…Acemannan was demonstrated to significantly increase the proliferation of bone marrow stem cells (BMSCs), alkaline phosphatase (ALP) activity, mineralization, and expression of main factors for bone formation such as vascular endothelial growth factor (VEGF), and bone morphogenetic protein 2 (BMP-2) [23], while VEGF and BMP-2 have important roles in formation of new capillaries and osteoblast differentiation and regeneration of injured tissues [24].…”

Section: Discussionmentioning

confidence: 99%

The impact of acemannan, an extracted product from Aloe vera, on proliferation of dental pulp stem cells and healing of mandibular defects in rabbits

Mehrabani

2024

Am J Stem Cells

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Objectives: Dental pulp stem cells (DPSCs) were shown to play an important role in regenerative medicine including reconstruction of various bone lesions. This study determined the impact of acemannan, an extracted product from Aloe vera, on in vitro proliferation of DPSCs and in vivo healing of mandibular defects in rabbits. Methods: DPSCs were isolated and characterized. The growth kinetics of cells exposed to acemannan (8 mg/mL) and Hank's balanced salt solution (HBSS) were compared in vitro. Fifteen male rabbits were divided into 3 groups. Five animals were left as control group without any therapeutic intervention. Five rabbits were considered as experimental group 1 and received 20 µL of a cell suspension containing 10 6 DPSCs in the bone defect. Another 5 rabbits were regarded as experimental group 2 and were injected in the bone defect with 20 µL of a cell suspension containing 10 6 DPSCs treated with acemannan for 24 h. After 60 days, the animals were assessed by radiography and histologically. Results: The mesenchymal properties of DPSCs were confirmed. Population doubling time (PDT) of DPSCs treated with acemannan (29.8 h) was significantly shorter than cells were just exposed to HBSS (45.9 h). DPSCs together with acemannan could significantly accelerate the healing process and osteogenesis in mandibular defects. Conclusions: As DPSCS showed an increased proliferation when treated with acemannan and accelerated the healing process in mandibular defects, these findings can open a new avenue in dentistry regenerative medicine when remedies of bone defects are targeted.

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Section: Discussionmentioning

confidence: 99%

The impact of acemannan, an extracted product from Aloe vera, on proliferation of dental pulp stem cells and healing of mandibular defects in rabbits

Mehrabani

2024

Am J Stem Cells

View full text Add to dashboard Cite

show abstract

Angiogenic Potential and Its Modifying Interventions in Dental Pulp Stem Cells: a Systematic Review

Cited by 1 publication

References 86 publications

The impact of acemannan, an extracted product from Aloe vera, on proliferation of dental pulp stem cells and healing of mandibular defects in rabbits

The impact of acemannan, an extracted product from Aloe vera, on proliferation of dental pulp stem cells and healing of mandibular defects in rabbits

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