Angiosarcoma Arising from the Tongue of an 11-Year-Old Girl with Xeroderma Pigmentosum

Olson, Matthew T.; Püttgen, Katherine B.; Westra, William H.

doi:10.1007/s12105-011-0303-x

Cited by 21 publications

(18 citation statements)

References 16 publications

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“…A 15-year-old female from the Central African Republic presented with a history of XP and multiple tumors on the face, including BCC and melanoma in addition to angiosarcoma of the tongue (the pathologic findings of the tongue neoplasm have previously been reported) [8]. The patient first presented at the age of 10 with no light perception vision in the right eye and 20/40 in her left eye.…”

Section: Resultsmentioning

confidence: 99%

“…A preneoplastic spectrum known as conjunctival intraepithelial neoplasia (CIN), classified as mild, moderate, or severe depending on the depth of conjunctival epithelial dysplasia, can also present secondary to sun exposure with this underlying genetic disorder [3,4]. Other skin tumors including keratoacanthoma and fibrosarcoma [3] as well as angiosarcoma of the tongue have been additionally reported [8]. Atypical fibroxanthoma (AFX) is a benign tumor seen in previously sun-damaged skin of the head and neck in the elderly [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological Features of Ophthalmic Neoplasms Arising in the Setting of Xeroderma Pigmentosum

et al. 2015

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Background: Patients with xeroderma pigmentosum (XP) are strongly predisposed to the development of numerous cutaneous cancers. However, the extent of ocular pathology in these patients has not been adequately studied. Methods: We conducted a retrospective study of tumors involving the ocular surface and ocular adnexa from 6 XP patients. Histopathological evaluation and immunohistochemistry was performed using antibodies directed against the most common mutated proteins in XP (XPA, XPC, and XPD). Results: Patients included 4 males and 2 females with a mean age of 20.8 years (range 10-31) who met the clinical criteria for XP and were found to have a total of 13 neoplasms involving the ocular surface and adnexal skin; 6 squamous cell carcinomas (SCC), 3 cases of conjunctival intraepithelial neoplasia, 2 malignant melanomas, 1 basal cell carcinoma, and 1 atypical fibroxanthoma. Complete XPD loss was present in two tumors from 1 patient, suggesting a germline defect, and in the invasive component of an SCC from a second patient, suggesting a somatic alteration. No clear pattern of loss for XPA or XPC was evident. Conclusions: Our study outlines our early experience with the pathology of ocular neoplasms in XP patients. These findings deserve further exploration with genetic studies and additional patients.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinicopathological Features of Ophthalmic Neoplasms Arising in the Setting of Xeroderma Pigmentosum

et al. 2015

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“…Lesions were located at the tip of the tongue in eight cases and the dorsal tongue was affected in the remaining three . Olson et al reported an angiosarcoma at the tip of the tongue of a patient with XP.…”

Section: Discussionmentioning

confidence: 99%

An Atrophic, Telangiectatic Patch at the Distal Border of the Tongue: A Mucous Membrane Manifestation of Xeroderma Pigmentosum

Bologna

Teshima

Lourenço

et al. 2014

Pediatric Dermatology

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Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by clinical and cellular sensitivity, pigmentary changes, and early development of malignancies in sun-exposed mucocutaneous and ocular structures due to a defective ability to repair intracellular DNA damage. Individuals with XP also have a greater frequency of oral cancer, particularly squamous cell carcinoma of the anterior third of the tongue. The current study reports four cases of XP that exhibited a characteristic crescent-shaped, atrophic, telangiectatic area on the distal border of the tongue and correlates this lesion with the development of tumors at this site during follow-up. The tongue lesion was photographed and biopsied in the four patients. During routine follow-up visits, new biopsies were performed if additional tongue lesions were observed. The studied lesions were similar in the four patients. During follow-up, squamous cell carcinoma developed in one patient and pyogenic granuloma developed in three patients and was relapsing in one. The lesion remained stable in one patient during the study. The atrophic and telangiectatic patches probably occur because of chronic sun damage to the exposed portion of the tongue, and this area has a high predisposition for the development of benign and malignant tumors.

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“…Angiosarcoma is a xeroderma pigmentosum related tumor that usually arises in sun-exposed skin but can also arise in the oral cavity [5]. Angiosarcoma is one of the rarest tumors arising in the tongue, accounting for vanishingly small proportion of primary tongue sarcomas.…”

Section: Discussionmentioning

confidence: 99%

Primary Angiosarcoma of the Tongue: A Case Report

Chadha¹,

Rawat²,

Prasad³

2012

IJOHNS

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Angiosarcoma Arising from the Tongue of an 11-Year-Old Girl with Xeroderma Pigmentosum

Cited by 21 publications

References 16 publications

Clinicopathological Features of Ophthalmic Neoplasms Arising in the Setting of Xeroderma Pigmentosum

Clinicopathological Features of Ophthalmic Neoplasms Arising in the Setting of Xeroderma Pigmentosum

An Atrophic, Telangiectatic Patch at the Distal Border of the Tongue: A Mucous Membrane Manifestation of Xeroderma Pigmentosum

Primary Angiosarcoma of the Tongue: A Case Report

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