Angiosarcoma in the right atria demonstrated by fusion images of multislice computed tomography and positron emission tomography using F-18 Fluoro-Deoxyglucose

Hori, Yasuhiko; Funabashi, Nobusada; Miyauchi, Hideaki; Nakagawa, Keiichi; Shimura, Hitoshi; Miyazaki, M; Kozono, Hideaki; Nagai, Yuichiro; Ishikura, Hiroshi; Nagai, Toshio; Kobayashi, Yoshio; Komuro, Issei

doi:10.1016/j.ijcard.2006.11.093

Cited by 36 publications

(28 citation statements)

References 15 publications

(12 reference statements)

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“…The published cases of 18 F-FDG PET uptake in cardiac tumors are in line with the results of the present study: malignant cardiac tumors typically exhibit a high 18 F-FDG uptake. SUV max was available in 7 cardiac malignancies only (mean 6 SD, 8.8 6 3.63; 9.5 6 4.0 in the present study) (13)(14)(15)(16)21,22,25). Benign cardiac tumors are expected to show only slight 18 F-FDG uptake, although an exception was FIGURE 5.…”

Section: Discussionmentioning

confidence: 71%

“…The use of 18 F-FDG PET/CT to assess cardiac tumors is infrequently reported as single cases; the results of these reports are summarized in Table 1 (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). To date, larger patient groups undergoing whole-body 18 F-FDG PET/CT to elucidate the diagnostic performance of PET/CT in cardiac tumors have not yet been published.…”

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confidence: 99%

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Differentiation of Malignant and Benign Cardiac Tumors Using ¹⁸F-FDG PET/CT

Rahbar

Seifarth²,

Schäfers³

et al. 2012

J Nucl Med

233

108

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In the diagnostic algorithm of cardiac tumors, the noninvasive determination of malignancy and metastatic spread is of major interest to stratify patients and to select and monitor therapies. In the diagnostic work-up, morphologic imaging modalities such as echocardiography or magnetic resonance tomography offer information on, for example, size, invasiveness, and vascularization. However, preoperative assessment of malignancy may be unsatisfactory. The aim of this study was to evaluate the diagnostic value of 18 F-FDG PET and the incremental diagnostic value of an optimized CT score in this clinical scenario. Methods: 18 F-FDG PET/CT scans (wholebody imaging with low-dose CT) of 24 consecutive patients with newly diagnosed cardiac tumors were analyzed (11 men, 13 women; mean age 6 SD, 59 6 13 y). The maximum standardized uptake values (SUV max ) of the tumors were measured. Patients were divided into 2 groups: benign cardiac tumors (n 5 7) and malignant cardiac tumors (n 5 17) (cardiac primaries [n 5 8] and metastases [n 5 9]). SUV max was compared between the 2 groups. Results were compared with contrast-enhanced CT, using standardized criteria of malignancy. Histology served as ground truth. Results: Mean SUV max was 2.8 6 0.6 in benign cardiac tumors and significantly higher both in malignant primary and in secondary cardiac tumors (8.0 6 2.1 and 10.8 6 4.9, P , 0.01). Malignancy was determined with a sensitivity of 100% and specificity of 86% (accuracy, 96%), after a cutoff with high sensitivity (SUV max of 3.5) was chosen to avoid false-negatives. Morphologic imaging reached a sensitivity of 82% and a specificity of 86% (accuracy, 83%). Both false-positive and false-negative decisions in morphology could be corrected in all but 1 case using a metabolic threshold with an SUV max of 3.5. In addition, extracardiac tumor manifestations were detected in 4 patients by whole-body 18 F-FDG PET/CT. Conclusion: 18 F-FDG PET/ CT can aid the noninvasive preoperative determination of malignancy and may be helpful in detecting metastases of malignant cardiac tumors.

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Section: Discussionmentioning

confidence: 71%

mentioning

confidence: 99%

Differentiation of Malignant and Benign Cardiac Tumors Using ¹⁸F-FDG PET/CT

Rahbar

Seifarth²,

Schäfers³

et al. 2012

J Nucl Med

233

108

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“…MSCT is a useful method to evaluate cardiac anatomy [74][75][76][77][78][79][80][81][82][83] and is frequently used prior to RFCA for AF [15,84]. Transesophageal echocardiography remains the gold standard for identification of LAA thrombus and is performed prior RFCA for AF or electrical cardioversion [85].…”

Section: Indications For Ct Acquisitionmentioning

confidence: 99%

Left atrial wall thickness in paroxysmal atrial fibrillation by multislice-CT is initial marker of structural remodeling and predictor of transition from paroxysmal to chronic form

Nakamura¹,

Funabashi²,

Uehara³

et al. 2011

International Journal of Cardiology

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“…They are proving its usefulness in assessing malignant potential of the tumour mass and exploration for distant metastases in primary diagnosis together with metabolic response to and detection of local recurrence after applied therapy [5][6][7][8]. In the presented case PET-CT with 18FDG depicted persisted high metabolic activity in the tumour mass despite three courses of adjuvant chemotherapy and metabolically active metastases in the skeleton, not visible on previously scheduled imaging studies.…”

Section: Discussionmentioning

confidence: 73%